Risk factors in Hymenoptera venom allergy

Ruëff, Franziska; Kroth, Julia; Przybilla, Bernhard

doi:10.5414/alx01320e

Cited by 13 publications

(20 citation statements)

References 37 publications

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“…A lack of correlation between the venom sIgE level and the severity of clinical symptoms after a sting has been repeatedly reported in the literature. However, the studies with a provoked sting in patients with an elevated exposure to stings and without a history of severe anaphylactic reaction showed that an elevated level of venom-specific IgE was a risk factor for a systemic anaphylactic reaction (SAR) [ 18 ]. There are no literature data on the correlations between clinical symptoms after a sting and phospholipase A 2 sIgE levels in beekeepers.…”

Section: Discussionmentioning

confidence: 99%

The correlation between anti phospholipase A 2 specific IgE and clinical symptoms after a bee sting in beekeepers

Matysiak

Bręborowicz

et al. 2016

pdia

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IntroductionBeekeepers are a group of people with high exposure to honeybee stings and with a very high risk of allergy to bee venom. Therefore, they are a proper population to study the correlations between clinical symptoms and results of diagnostic tests.AimThe primary aim of our study was to assess the correlations between total IgE, venom- and phospholipase A2-specific IgE and clinical symptoms after a bee sting in beekeepers. The secondary aim was to compare the results of diagnostic tests in beekeepers and in individuals with standard exposure to bees.Material and methodsFifty-four individuals were divided into two groups: beekeepers and control group. The levels of total IgE (tIgE), venom-specific IgE (venom sIgE), and phospholipase A2-specific IgE (phospholipase A2 sIgE) were analyzed.ResultsOur study showed no statistically significant correlation between the clinical symptoms after a sting and tIgE in the entire analyzed group. There was also no correlation between venom sIgE level and clinical symptoms either in beekeepers or in the group with standard exposure to bees. We observed a statistically significant correlation between phospholipase A2 sIgE level and clinical signs after a sting in the group of beekeepers, whereas no such correlation was detected in the control group. Significantly higher venom-specific IgE levels in the beekeepers, as compared to control individuals were shown.ConclusionsIn beekeepers, the severity of clinical symptoms after a bee sting correlated better with phospholipase A2 sIgE than with venom sIgE levels.

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Section: Discussionmentioning

confidence: 99%

The correlation between anti phospholipase A 2 specific IgE and clinical symptoms after a bee sting in beekeepers

Matysiak

Bręborowicz

et al. 2016

pdia

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“…Identifying patient risk factors associated with re-sting allergic reaction is an important piece of the puzzle, especially when determining whether a patient will benefit from venom immunotherapy. Data show that males tend to develop anaphylaxis more frequently than females 11. Older patients develop more severe reactions overall than younger people, possibly due to the higher incidence of previous sting reactions 11.…”

Section: Risk Factorsmentioning

confidence: 98%

“…Data show that males tend to develop anaphylaxis more frequently than females 11. Older patients develop more severe reactions overall than younger people, possibly due to the higher incidence of previous sting reactions 11. Patients stung by wasp species also are more likely to have severe reactions 11.…”

Section: Risk Factorsmentioning

confidence: 99%

“…Older patients develop more severe reactions overall than younger people, possibly due to the higher incidence of previous sting reactions 11. Patients stung by wasp species also are more likely to have severe reactions 11. A study that looked specifically at wasp and honeybee venom determined that a short sting-to-reaction time and a lack of cutaneous symptoms were directly related to increased severity of reaction 12.…”

Section: Risk Factorsmentioning

confidence: 99%

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Reducing the sting

Boburka

2021

Jaapa

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Hymenoptera species include stinging insects such as wasps, hornets, bees, and fire ants. Allergic reaction to the venom of these insects is a common presenting complaint for patients in primary care and emergency medicine during warmer months. Patients' clinical presentations may vary, and clinicians must identify the type of reaction to determine treatment and follow-up plans. Treatment of patients allergic to Hymenoptera venom should be individualized based on risk factors, reaction type, and associated comorbidities. This article reviews common features of clinical presentation, diagnosis, and the current mainstays in management of Hymenoptera venom allergy.

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“…A study from Austria found that patients with Hymenoptera venom allergy and high levels of tIgE predominantly develop milder SSR, while patients with low tIgE more often develop severe SSR [ 15 ]. Other risk factors for SSR have been described as a consequence of exposure: (i) beekeepers and their family members or neighbours; (ii) work in a fruit or bakery shop or as a groundworker, gardener, firefighter or farmer; (iii) outdoor leisure activities like working in the garden, swimming, golfing or cycling and (iv) motorcycling [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Natural History of the Hymenoptera Venom Sensitivity Reactions in Adults: Study Design

Perčič

Bojanić

Košnik

et al. 2022

IJERPH

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Background: Allergic reactions to Hymenoptera stings can have varying levels of severity, according to the Müller grading system. Methods: By an epidemiological concept, this is a retrospective cohort study. The observed cohort was represented by patients referred to the University Clinic Golnik due to Hymenoptera allergic reaction in the period from 1997 to 2015. From the immunological database of the University Clinic Golnik, we obtained laboratory data (sIgE, skin tests and basophil activation test). The clinical characteristics of patients were obtained from BIRPIS. With the help of a questionnaire, which was sent to each patient in the period from May 2019 to April 2021, we obtained epidemiological data. For the assessment of the association between the severity of allergic reaction for the observed outcome, the severity of the first allergic reaction after Hymenoptera sting was used. Other variables were grouped according to risk factors. Discussion: We will identify the risk factors that could play an important role in a severe systemic reaction: the aetiology of the Hymenoptera sting, sex, age, history and severity of previous systemic reactions, being re-stung in an interval of two months, the frequency of re-stings, atopy, genetic predisposition, preventive medication use, other medication use, beekeeping or living next to beehives and why immunotherapy was not taken. Laboratory data will also be analysed to determine if there is any association with laboratory tests and the severity of the allergic reactions after Hymenoptera stings. Conclusions: Several new approaches are introduced in the study design. The most important is that the protocol covers epidemiological data gained from the questionnaire, as well as clinical data gained from the Immunological database and BIRPIS database. We expect to obtain significant results that will explain the risk factors for the natural history of Hymenoptera sting allergic reactions and will help allergologists, as well as general doctors, when facing those patients allergic to Hymenoptera venom without immunotherapy.

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Risk factors in Hymenoptera venom allergy

Cited by 13 publications

References 37 publications

The correlation between anti phospholipase A 2 specific IgE and clinical symptoms after a bee sting in beekeepers

The correlation between anti phospholipase A 2 specific IgE and clinical symptoms after a bee sting in beekeepers

Reducing the sting

Natural History of the Hymenoptera Venom Sensitivity Reactions in Adults: Study Design

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