Risk Factors in Congenital Heart Disease

Roodpeyma, Shahla; Kamali, Zinat; Afshar, Farnoush; Naraghi, Shahrbanou

doi:10.1177/000992280204100903

Cited by 33 publications

(47 citation statements)

References 20 publications

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“…8,9 In present study, majority (48.6%) of total echocardiographic examination had been performed because of maternal condition which includes traditional risk factors with detection rate of only 2.4%.Although screening patient with traditional risk factor is indicated, reports have been there of detecting most cardiac defect in low risk pregnancy. 10 Suspected cardiac or noncardiac malformations on sceering sonography was the second most common indication for referral in our study. Similar referral patterns were reported by various authors.…”

Section: Discussionmentioning

confidence: 63%

Fetal Echocardiography:Short Term Profile from Shahid Gangalal National Heart Centre, Kathmandu, Nepal

Regmi

Sharma

2016

Nepalese Heart J.

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Background and Aims: Fetal echocardiography is helpful in early detection of Congenital Heart Disease.Our study was conducted to evaluate the most common indications of referral and outcome in a tertiary-care fetal echocardiography practice. Methods: A Cross-sectional analysis of all pregnant women referred by obstetricians to cardiology unit for fetal echocardiography over a 1-year period (July 2014 and July 2015) was performed. The primary indications for referral for fetal echocardiography were obtained from the obstetric referral forms. Outcome data were extracted from performa containing client's demographic, physical examination and the fetal echocardiograhic data. Postnatal Echocardiography was advised to all cases having positive echocardiographic finding. Results: A series of 251 fetal cardiac studies were reviewed. Average gestational age was 25.6 weeks (range, 18 to 38 weeks). Thirty-eight (15.1%) pregnant women had abnormal fetal cardiac findings. The most common referral for fetal cardiac scan was related to maternal indications (48.6%). Other indications were abnormal prenatal fetal findings in ultrasonography (23.1%), family history of CHD (12%), general screening (15.5%), and follow up of IVF(In-vitro fertilization) (0.8%). The highest yield of significant abnormal findings was there among patients referred with abnormal prenatal fetal finding in ultrasonography (47%). Conclusion: Majority of referral were for abnormal prenatal ultrasonographic findings. So, fetal echocardiography is an important part of overall management of the pregnancy at risk for producing an infant with congenital heart disease.

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Section: Discussionmentioning

confidence: 63%

Fetal Echocardiography:Short Term Profile from Shahid Gangalal National Heart Centre, Kathmandu, Nepal

Regmi

Sharma

2016

Nepalese Heart J.

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“…Consanguinity is another added risk factor within these families where it is culturally accepted practice [1, 2,9,10,11]. In addition, the prevalence of congenital heart disease in Down syndrome was found to be higher in the population with widely prevalent consanguinity [12].…”

Section: Discussionmentioning

confidence: 99%

Influence of Consanguinity on the Pattern of Familial Aggregation of Congenital Cardiovascular Anomalies in an Outpatient Population

Seliem

Bou-Holaigah²,

Al‐Sannaa³

2006

Public Health Genomics

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Background: Familial aggregation of congenital heart disease (CHD) has been well described in different populations, in particular those with a high consanguinity rate. Extensive genetic study of affected families has improved the understanding of basic genetics of different cardiac lesions. Objective: To identify the role of consanguinity as a risk factor among familial cases of CHD in a stable outpatient population of a tertiary care center in the Eastern Province of Saudi Arabia. Methods: All familial cases of CHD seen over 5 years (1996–2000) in the Division of Pediatric Cardiology were identified. The presence or absence of parental consanguinity (first cousin marriage) was defined in each of these families. Results: Ninety-three cases were identified in 37 families. Twenty-three (62%) families resulted from consanguineous marriages. In 4 families where there were 2 marriages, the affected children came from the consanguineous marriage in 3 of these families. Discordant lesions occur only among non-consanguineous cases, while all consanguineous cases were concordant. Five sets of twins of the same sex (one set are monozygotic by DNA analysis) occurred among consanguineous marriages, in 3 of these both twins were affected with the same disease. Affected parents were seen in 2 families with consanguineous marriage and none in the non-consanguineous marriages. The prevalence of dilated cardiomyopathy was much higher among consanguineous cases (26 vs. 2). Conclusions: Familial aggregation of congenital heart disease is common in our population. Consanguinity is common in these families, and the distribution of congenital heart disease differs in this subgroup compared to the rest of the familial cases. Further genetic studies of these families may help to shed more light on basic genetics and the specific pathogenetic mechanisms involved.

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“…Multiple system involvement is described as a risk factor for CHD treatment [3,19]. Association of esophageal atresia and tracheoesophageal fistula with ToF, presence of VACTERL, or choanal atresia usually contributes to a poor outcome [2,3,14].…”

Section: Discussionmentioning

confidence: 99%