2020
DOI: 10.1183/13993003.01190-2020
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Risk factors for viral RNA shedding in COVID-19 patients

Abstract: Take home message: The median time from symptoms onset to viral RNA shedding was 19 days. Patients with CHD comorbidity or decreased albumin levels experienced delays in clearance of SARS-CoV-2 RNA.

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Cited by 73 publications
(88 citation statements)
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“…On multivariate analysis, old age, malignancy, steroid use, and concomitant pneumonia were identified as risk factors for prolonged viral shedding in this study, consistent with previous studies ( Fu et al, 2020 , Yan et al, 2020a , Yan et al, 2020b , Zhou et al, 2020 ). Old age, comorbidities, and steroid use might blunt the host immune response, thereby promoting viral replication.…”
Section: Discussionsupporting
confidence: 91%
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“…On multivariate analysis, old age, malignancy, steroid use, and concomitant pneumonia were identified as risk factors for prolonged viral shedding in this study, consistent with previous studies ( Fu et al, 2020 , Yan et al, 2020a , Yan et al, 2020b , Zhou et al, 2020 ). Old age, comorbidities, and steroid use might blunt the host immune response, thereby promoting viral replication.…”
Section: Discussionsupporting
confidence: 91%
“…When analyzing the effect of antiviral agents, the timing of antiviral therapy is an important issue to be considered. Early (within 7 days from symptom onset) initiation of antiviral therapy may be critical in reducing SARS-CoV-2 viral load, as previously noted ( Fu et al, 2020 , Keyaerts et al, 2004 , Yan et al, 2020a , Yan et al, 2020b ). Due to the limitation of our database, it was difficult to know the initiation timing of antiviral treatment in each individual patient; however, the government of South Korea had launched a series of aggressive measures to perform tight contact tracing and mass screening tests, which enabled early diagnosis within 3–5 days from symptom onset ( Ryu et al, 2020 ).…”
Section: Discussionmentioning
confidence: 58%
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“…The ECDC recommends two consecutive negative RT-PCR tests from respiratory specimens at 24 h interval at least 8 days after symptoms onset to discontinue isolation precautions in hospitalized COVID-19 patients [10]. Similar recommendations were issued by several institutions in other continents [5,19]. Specimens were usually collected in the upper respiratory tract, and data on lower respiratory samples are rarely considered.…”
Section: Discussionmentioning
confidence: 99%
“…Viral RNA has been shown to be detectable in recovered patients, although the duration of viral RNA shedding reported varied among infected patients. Viral RNA shedding can last at least 6 weeks [12][13][14][15][16]. Liu et al reported that patients with severe symptoms had a higher viral load and a longer viral shedding period than patients with mild symptoms (<10 days for the group with mild symptoms and >10 days for the group with severe symptoms).…”
Section: Introductionmentioning
confidence: 99%