Risk Factors for Urinary Tract Infection After Renal Transplantation and its Impact on Graft Function in Children and Young Adults

Silva, Andres; Rodig, Nancy; Passerotti, Carlo P.; Recabal, Pedro; Borer, Joseph G.; Retik, Alan B.; Nguyen, Hiep T.

doi:10.1016/j.juro.2010.06.028

Cited by 41 publications

(34 citation statements)

References 25 publications

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“…Additionally, all boys in the present study were circumcised early in infancy as a routine social and religious practice. However, other studies did not report a higher incidence of UTI in girls . A higher incidence of UTI Post‐Tx was also reported in children with LUTD .…”

Section: Discussionmentioning

confidence: 82%

Risk factors for urological complications following living donor renal transplantation in children

ElSheemy

Ghoneima

Aboulela

et al. 2017

Pediatric Transplantation

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The aim of this study was to detect possible risk factors for UC and UTI following pediatric renal Tx and effect of these complications on outcome. One hundred and eight children who underwent living donor Tx between 2009 and 2015 were retrospectively included. Extraperitoneal approach was used with stented tunneled extravesical procedure. Mean recipient age was 9.89 ± 3.46 years while mean weight was 25.22 ± 10.43 kg. Seventy-three (67.6%) recipients were boys while 92 (85.2%) were related to donors. Urological causes of ESRD were present in 33 (30.6%) recipients (14 [13%] posterior urethral valve, 16 [14.8%] VUR, and 3 [2.8%] neurogenic bladder). Augmentation ileocystoplasty was performed in 9 (8.3%) patients. Mean follow-up was 39.3 ± 17.33 months. UC were detected in 10 (9.3%) children (leakage 4 [3.7%], obstruction 3 [2.8%], and VUR 3 [2.8%]) while UTIs were reported in 40 (37%) children. After logistic regression analysis, UC were significantly higher in children with cystoplasty (44.4% vs 6.1%; P = .001). UTIs were significantly higher in girls (51.4% vs 30.1%; P = .001) and in children with urological causes of ESRD (51.5% vs 30.7%; P = .049). UC and UTI were not significantly associated with increased graft loss or mortality. UC were significantly higher in children with cystoplasty while UTIs were significantly higher in girls and children with urological causes of ESRD. Presence of UC did not affect the rate of graft loss or mortality due to its early detection and proper management.

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Section: Discussionmentioning

confidence: 82%

Risk factors for urological complications following living donor renal transplantation in children

ElSheemy

Ghoneima

Aboulela

et al. 2017

Pediatric Transplantation

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“…Several studies concluded that the presence of lower urinary tract abnormality is a significant risk factor for posttransplant UTI [12,13]. However the prevalence of UTI in LUTD (þ) patients varies widely in the literature due to many factors, such as differences in the definition of UTI, agents chosen for prophylaxis, etc.…”

Section: Discussionmentioning

confidence: 99%

Does Lower Urinary Tract Status Affect Renal Transplantation Outcomes in Children?

Aki¹,

Aydın²,

Doğan³

et al. 2015

Transplantation Proceedings

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“…Numerous risk factors have been identified including young age, Caucasian race, male gender, specific immunosuppressive medications, and type of organ transplanted [19–22]. However, primary EBV infection is considered to be the most important [19, 20, 23, 24].…”

Section: Epstein Barr Virusmentioning

confidence: 99%

Viral surveillance and subclinical viral infection in pediatric kidney transplantation

Smith

Dharnidharka

2014

Pediatr Nephrol

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The more potent immunosuppressive therapy that has successfully reduced the incidence of acute rejection and improved graft outcomes has also resulted in a higher incidence of viral complications. Sensitive molecular methods now allow for the detection of subclinical viral infection which is increasingly recognized due to the adoption of routine post-transplant viral surveillance protocols. The goal of viral surveillance is the detection of subclinical viral infection that triggers an intervention; one that either prevents progression to viral disease or leads to early diagnosis of viral disease which is associated with improved outcomes. Knowledge of the epidemiology and natural history of subclinical viral infection and disease, as well as patient specific risk factors, is required to establish the optimal surveillance schedule which achieves the goal of early diagnosis. Evidence that detection of subclinical viral infection can impact viral disease is variable depending on the virus. This review will summarize the current data on the role of viral surveillance for BK virus (BKV), cytomegalovirus (CMV) and Epstein Barr virus (EBV) in the pediatric kidney transplant population.

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Risk Factors for Urinary Tract Infection After Renal Transplantation and its Impact on Graft Function in Children and Young Adults

Cited by 41 publications

References 25 publications

Risk factors for urological complications following living donor renal transplantation in children

Risk factors for urological complications following living donor renal transplantation in children

Does Lower Urinary Tract Status Affect Renal Transplantation Outcomes in Children?

Viral surveillance and subclinical viral infection in pediatric kidney transplantation

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