Risk factors for urinary, fecal, or double incontinence in women

Matthews, Catherine A.

doi:10.1097/gco.0000000000000094

Cited by 24 publications

(17 citation statements)

References 19 publications

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“…Like aging, obesity is an important risk factor for urinary incontinence in women [20]. This association is most likely explained by metabolic changes within the muscle tissue [21] that reduce the ability of muscle cells to regenerate.…”

Section: Discussionmentioning

confidence: 99%

Determinates of muscle precursor cell therapy efficacy in a nonhuman primate model of intrinsic urinary sphincter deficiency

et al. 2017

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BackgroundCell therapy for intrinsic urinary sphincter deficiency (ISD) in women has been moderately effective, and improvements are needed. To improve treatment efficacy, it is important to better understand determinates of cell efficacy in the different patient cohorts. We have reported that in nonhuman primates the chronicity of ISD may affect cell efficacy, but additional factors (age, psychosocial stress, hormone status, body weight) can be associated with many disease/treatment outcomes in women – and these factors are the focus of this study.MethodsAdult female cynomolgus monkeys were divided into groups: (1) younger (n = 10, 5–8 years of age) versus older (n = 10, 13–18 years of age); (2) age-matched/socially subordinate (n = 15) versus socially dominant (n = 15); and (3) age-matched lower body weight (n = 6) versus higher body weight (n = 6). Autologous skeletal muscle precursor cells (skMPCs, 5 million) were injected into the urinary sphincter 6 weeks after a surgically induced ISD procedure. Resting and pudendal nerve-stimulated maximal urethral pressures (MUP) were measured before, and 3 and 6 months post-skMPC treatment and urinary sphincter muscle/collagen content within the sphincter complex was measured by quantitative histology 6 months posttreatment.ResultsEfficacy of skMPCs on MUP and sphincter muscle/collagen ratios are affected by age (average 40% reduction in efficacy, p < 0.05 vs. younger NHPs), social stress (average 30% reduction in efficacy, p < 0.05 vs. socially dominant) and body weight/fasting glucose concentrations (average 35% reduction in efficacy, p < 0.05 vs. lower body weight).ConclusionMultiple factors (age, stress-induced dysmenorrhea, and body weight) affect the efficacy of cell therapy to restore structure and function in the urinary sphincter complex in NHPs with ISD. Consideration of, and alternatives for, these patient cohorts should be considered.

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Section: Discussionmentioning

confidence: 99%

Determinates of muscle precursor cell therapy efficacy in a nonhuman primate model of intrinsic urinary sphincter deficiency

et al. 2017

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“…These two conditions often co-exist and are then called mixed incontinence (74). Risk factors for UI in women, apart from pelvic radiotherapy, are surgeries such as hysterectomy, advancing age, vaginal delivery, number of deliveries, constipation, BMI greater than 30kg/m 2 , generalized weakening of connective tissue, hormone deficiency, genital mutilation, and depression (74)(75)(76). According to a study by Bernard et al, pelvic floor muscle strength and endurance corresponds to the severity of UI in endometrial cancer survivors after hysterectomy and radiotherapy (58).…”

Section: Urinary Incontinencementioning

confidence: 99%

“…Risk factors associated with FI in women, in addition to pelvic radiotherapy, are advancing age, loose stools or diarrhea, fecal urgency, type 2 diabetes mellitus, inflammatory bowel disease, BMI greater than 30kg/m 2 , vaginal delivery, number of deliveries, birthweight of the child, obstetric trauma such as anal sphincter trauma, multiple chronic medial illness, and UI (75,79,80). In addition, surgery in conjunction with pelvic cancer treatment, such as anterior resection in patients with rectal cancer, is associated with an increased risk of FI due to impaired functioning of the intestine.…”

Section: Fecal Incontinencementioning

confidence: 99%

Incontinence, physical activity, and pelvic floor muscle training in female pelvic cancer survivors after radiotherapy

Lindgren

2020

Linköping University Medical Dissertations

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Background: Cancer treatment continues to improve, contributing to an evergrowing population of cancer survivors. Pelvic cancer survivors (PCS) constitute the second largest group of female cancer survivors after breast cancer. Many female PCS have been treated with radiotherapy as a part of their cancer treatment. Unfortunately, like all effective cancer treatments, pelvic radiotherapy is associated with a risk of subsequent, unwanted side effects. Some side effects remain or persist long after the end of treatment and some are even lifelong. A common and burdensome side effect after pelvic radiotherapy is urinary and/or fecal incontinence. Incontinence is known to negatively affect quality of life (QoL) and physical activity levels. Physical activity contributes to several positive health effects. In cancer survivors, it may reduce the risk of recurrence and even the mortality risk. Cancer survivors in general, and female PCS in particular, tend to be less physically active after cancer treatment than before treatment. When suffering from urinary and even fecal incontinence, pelvic floor muscle training (PFMT) is recommended as a first-line treatment for the general population. In addition to decreased incontinence levels, PFMT may contribute to increased physical activity and better QoL. However, little attention is given to PFMT as a potential treatment for incontinence in the Swedish national care program for pelvic cancer rehabilitation. Furthermore, there is as yet no evidence that PFMT is as effective in female PCS as in female non-cancer survivors. The effectiveness of PFMT cannot be taken for granted because female PCS survivors often have treatment-induced damage to structures in the pelvic floor that might affect its applicability. However, the problem of incontinence among female PCS remains, along with the fact that they tend to be less physically active than other cancer survivors. Indeed, this is an important research area and a necessary problem for health-care providers to resolve, not least for physiotherapists. Aim: The overall aim of this thesis is to improve the understanding of female PCS' experiences of incontinence in relation to physical activity, QoL, and rehabilitative efforts, including PFMT. This includes gaining increased knowledge about the relation between incontinence and physical activity in the form of exercise and QoL, and whether PCS experience that physiotherapy contributes in a valuable way to reducing their incontinence. This could enable the development of meaningful physiotherapeutic interventions, that PCS can and are willing to engage in, to achieve a potential reduction in incontinence, as well as increased QoL and activity levels. Methods: The thesis includes four different studies, using three different methods, all conducted with female PCS. Studies I (n=13) and IV (n=11) are qualitative individual interview studies, using semi-structured interview guides. Study II is a cohort-based cross-sectional observational study (n=578) and Study III is a prospective cohort-b...

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“…Кроме того, показано большое значение в этом процессе гормона сна (мелатонина), гормона роста (соматотропина), оказывающего физиологические эффекты через инсулиноподобный фактор роста 1, а также гормонов жировой ткани (лептина, адипонектина, адипсина, резистина, десмина и др.) [27][28][29][30][31][32][33][34][35]. Кроме классического дистанционного механизма гормональной регуляции, осуществляемой гормонами специализированной эндокринной системы, в клетках мочевого пузыря имеются и локальные гормональные сигнальные пути, реализуемые через Лекции для врачей…”

Section: роль гормональных механизмов в регуляции функций мочевого пуunclassified

Hormonal Mechanisms of the Pathogenesis of Chronic Recurrent Cystitis in Women as Promising Pharmacotherapeutic Targets for Disease Management

Tyuzikov¹

2019

EPh

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Risk factors for urinary, fecal, or double incontinence in women

Abstract: Knowledge regarding which clinical conditions and patient characteristics are strongly associated with each type of incontinence helps identify those patients who are at risk and aids in targeted screening and treatment programs.

Cited by 24 publications

References 19 publications

Determinates of muscle precursor cell therapy efficacy in a nonhuman primate model of intrinsic urinary sphincter deficiency

Determinates of muscle precursor cell therapy efficacy in a nonhuman primate model of intrinsic urinary sphincter deficiency

Incontinence, physical activity, and pelvic floor muscle training in female pelvic cancer survivors after radiotherapy

Hormonal Mechanisms of the Pathogenesis of Chronic Recurrent Cystitis in Women as Promising Pharmacotherapeutic Targets for Disease Management

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