Risk factors for ulcerative colitis-associated colorectal cancer

Abstract

Inflammatory bowel disease is associated with an increased risk of colorectal cancer. The study aims to identify the risk factors for ulcerative colitis-colorectal cancer and to perform a survival curve analysis of the outcome. This retrospective cohort study included 254 patients from March 2016 to October 2017. Age, age at diagnosis, follow-up time, smoking status, and family history of colorectal cancer were analyzed as risk factors for colorectal cancer. The mean patient age was 46.6 ± 16.9 years; 5.5% of the patients were smokers and 49.6% had pancolitis. Six patients (2.36%) had colorectal cancer, which was associated with age at diagnosis (odds/hazard ratio 1.059 [95% confidence interval: 1.001–1.121]; P = .04), family history of colorectal cancer (12.992 [1.611–104.7]; P = .02), and follow-up time (0.665 [0.513–0.864]; P = .002). Active smoking was the main identified risk factor, after both logistic (8.477 [1.350–53.232]; P = .02) and Cox proportional-hazards (32.484 [2.465–428.1]; P = .008) regression analysis. The risk of colorectal cancer was 3.17% at 10 years and 4.26% at 20 years of follow-up. Active smoking and family history were identified as risk factors for colorectal cancer. These findings should aid the early identification of patients who require vigorous surveillance, and prevent exposure to risk factors.

Correlation of ulcerative colitis and colorectal cancer: a systematic review and meta-analysis

“…Previous studies have shown that the main area of colon cancer incidence (25,26). Although recent studies have suggested that patients with UC do not have a particularly high rate of CRC conversion, the prevalence is still very high compared with the general population (27,28). Numerous studies have suggested ethnic differences in the incidence of UC, with most previous statistical studies focusing on European regions (29).…”

Therapeutic implications of inflammasome in inflammatory bowel disease

“…Those who suffer, have increased mortality with a risk of cancer, blood clots, and primary sclerosing cholangitis. 6 IBD may occur at any age through adolescents to adults irrespective of the sex. Genetic, environmental, and immunological factors contribute in unison toward compromising the intestinal epithelial barrier function increasing the risk of disease.…”

“…Symptoms of both CD and UC include intermittent abdominal pain, weight loss, diarrhea, rectal bleeding, fever, and fatigue. Those who suffer, have increased mortality with a risk of cancer, blood clots, and primary sclerosing cholangitis 6 . IBD may occur at any age through adolescents to adults irrespective of the sex.…”

Cardamonin Attenuates Experimental Colitis and Associated Colorectal Cancer

“…IBD consists of two types of idiopathic disorders (Crohn’s disease and ulcerative colitis) which lead to inflammation of the colonic mucosa. The cumulative risk of developing CRC is estimated to be as high as 30% for those with IBD [ 3 , 4 ].…”