Risk factors for tuberculous empyema in pleural tuberculosis patients

Peng, Wen; Wei, Min; Han, Chao; He, Yu; Wang, Mao‐Shui

doi:10.1038/s41598-019-56140-4

Cited by 18 publications

(18 citation statements)

References 30 publications

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“…[ 5 ] Although the majority of pleural TB patients are cured after treatment with standardized anti-TB regimens, a small proportion of patients progress to tuberculosis empyema (TE) in spite of medical treatment, [ 6 ] further leading to formation of chronic and fatal sequelae. [ 7 ]…”

Section: Introductionmentioning

confidence: 99%

Risk factors associated with postoperative respiratory failure in tuberculous empyema patients

Ruan¹,

Liu

Gong³

et al. 2021

Medicine

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Our objective was to identify independent risk factors for predicting which patients in the Chinese population would likely develop respiratory failure. A descriptive analysis was conducted of demographic and clinical data of patients with tuberculous empyema (TE) admitted to the Beijing Chest Hospital, Capital Medical University between January 2001 and January 2020. Risk factors associated with postsurgical respiratory failure in TE patients were identified based on results of analyses based on univariable and multivariable logistic regression models. A total of 139 TE patients who underwent surgical treatment in the Beijing Chest Hospital, Capital Medical University from January 2001 to January 2020 were enrolled in this study. Cases included 109 male and 30 female patients, with an overall mean age (range 17–73) of 39.3 years. Of 139 TE patients, 26 (18.7%) experienced respiratory failure after surgery. Among significant risk factors for postsurgical respiratory failure, intraoperative blood loss volume greater than 1000 mL had the highest odds ratio value of 6.452. In addition, a pathologic preoperative pulmonary function test result showing a high partial pressure of carbon dioxide level was an independent risk factor for respiratory failure. Moreover, the presence of tuberculosis lesions in the contralateral lung was another significant risk factor for respiratory failure, as determined using multivariate analysis. Respiratory failure is a predominant complication experienced by TE patients undergoing surgery. High intraoperative blood loss, high preoperative high partial pressure of carbon dioxide level, and tuberculosis lesion(s) in the contralateral lung of TE patients were associated with increased risk of postoperative respiratory failure.

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Section: Introductionmentioning

confidence: 99%

Risk factors associated with postoperative respiratory failure in tuberculous empyema patients

Ruan¹,

Liu

Gong³

et al. 2021

Medicine

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“…17 The study by Wen et al conducted in 2019 had reported a decrease in the incidence of tubercular related fibrothorax but an increase in the pyogenic infective etiology more so in children. 18 A study conducted by Kundu et al in the Indian subcontinent region identified that of the 75 cases of empyema seen during their one and half year period 29 cases (38.7%) were of tuberculosis etiology and 46 (61.3%) were due to non-tubercular etiology with staphylococcus aureus being the most common. 19 All the patients were investigated for culture and sensitivity from the bronchial wash specimens taken during bronchoscopy.…”

Section: Resultsmentioning

confidence: 99%

Outcomes of pleural decortication in a tertiary care hospital of Telangana state

et al. 2020

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Background: The objective of the study was to study the clinical profile, incidence of postoperative complications in patients undergoing pleural decortication.Methods: The subjects for the study were selected from the cases admitted in a single unit of Department of Cardiothoracic Surgery, Nizam’s Institute of Medical Sciences, Hyderabad during the period of 2016 to 2018 and due ethics committee approval was taken. Collection of data is done from the database including admission record, ICU charts, discharge records and follow-up records. 50 patients underwent surgery. Outcomes and complications were analyzed for 3 years duration.Results: 50 patients were included in this study with different aetiologies that required pleural decortication. The average age of patients in our study was 34 years. Most patients in our study were male (80%) and had history of infection with tuberculosis (42%) and pyogenic (28%) infection. A few patients had history of trauma (12%). Most of the patients suffered from cough (88%), dyspnoea (74%), fever (82%) and haemoptysis (22%). The common postoperative complications we encountered were pleural air leak (37.5%) bleeding (25%) infection (25%) and recurrence (2%). Overall morbidity from pleural decortication was seen in 16 patients, and there was no mortality.Conclusions: The most common reason for pleural decortication is still empyema thoracis secondary to infection in the developing countries. Tuberculosis is still the most common cause leading to fibrothorax requiring pleural decortication followed closely by pyogenic lung infections and trauma.

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“…However, ADA is also present in hepatocytes, and when hepatocytes are damaged, the ADA level in the peripheral blood increases [15]. For example, the ADA level is notably elevated in Mycobacterium tuberculosis infection, autoimmune diseases, hepatitis, and malignant tumors [2][3][4]16]. Thus, ADA's expression and activity increase significantly during inflammation, and monocytes and macrophages are important sources of extracellular ADA [17].…”

Section: Discussionmentioning

confidence: 99%

Diversity of adenosine deaminase in children with EBV-related diseases

Shi

Zhang

et al. 2022

Ital J Pediatr

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Background Adenosine deaminase (ADA) is an enzyme involved in purine metabolism with an important role in cellular immunity. Thus, this study investigated the association between ADA and Epstein–Barr virus (EBV)-related diseases. Methods We retrospectively collected data from all children admitted to the Children’s Hospital of Soochow University, Suzhou, China, between May 1, 2018, and March 31, 2019, who underwent plasma EBV-DNA polymerase chain reaction, alanine aminotransferase (ALT), and ADA testing. Results Of 6868 children, 1877 had an elevated level of ADA, and 4991 had a level within the normal range. Multivariate logistic regression analysis indicated that ALT (adjusted odds radio [aOR] = 1.001, 95% confidence interval [CI]: 1.001–1.002), EBV infection (aOR = 8.486, 95% CI: 6.753–10.663), inflammatory disease (aOR = 3.915, 95% CI: 3.198–4.794), autoimmune disease (aOR = 2.307, 95% CI: 1.823–2.920), and malignant disease (aOR = 1.381; 95% CI: 1.101–1.734) were risk factors for an elevated ADA level. Furthermore, the ADA levels among EBV-related diseases significantly differed, including infectious mononucleosis, atypical EBV infection, respiratory infection, malignant disease, and other diseases (P < 0.05). In addition, the ADA level positively correlated with the Epstein–Barr viral load (r = 0.501, P < 0.05). Conclusions This large, retrospective study identified a correlation between ADA and EBV-related diseases, which may help clinicians detect these diseases earlier based on the plasma ADA concentration.

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Risk factors for tuberculous empyema in pleural tuberculosis patients

Cited by 18 publications

References 30 publications

Risk factors associated with postoperative respiratory failure in tuberculous empyema patients

Risk factors associated with postoperative respiratory failure in tuberculous empyema patients

Outcomes of pleural decortication in a tertiary care hospital of Telangana state

Diversity of adenosine deaminase in children with EBV-related diseases

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