Risk factors for treatment failure in scabies: a cohort study

Aussy, Audrey; Houivet, Estelle; Hebert,; Colas-Cailleux, H.; Laaengh, N; Richard, Clément; Ouvry, Marine; Boulard, C.; Léger, Sophie; Litrowski, N.; Bénichou, Jacques; Joly, Pierre

doi:10.1111/bjd.17348

Cited by 48 publications

(49 citation statements)

References 16 publications

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“…The resistance of S. scabiei to commercial products exists and might increase in the future, whereas treatment failures of scabies infections in animals and humans have been previously reported (15,(17)(18)(19). Beauvericin is known to be an ionophoric cyclodepsipeptide which forms complexes with cations and increases the permeability of biological membranes (20)(21)(22).…”

Section: Discussionmentioning

confidence: 99%

In Vitro Activity of Beauvericin against All Developmental Stages of Sarcoptes scabiei

Khoury

Nemer

et al. 2020

Antimicrob Agents Chemother

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Scabies is a frequent cutaneous infection caused by the mite Sarcoptes scabiei in a large number of mammals, including humans. As the resistance of S. scabiei against several chemical acaricides has been previously documented, the establishment of alternative and effective control molecules is required. In this study, the potential acaricidal activity of beauvericin was assessed against different life stages of S. scabiei var. suis and in comparison with dimpylate and ivermectin, two commercially available molecules used for the treatment of S. scabiei infection in animals and/or humans. The toxicity of beauvericin against cultured human fibroblast skin cells was evaluated using an MTT proliferation assay. In our in vitro model, developmental stages of S. scabiei were placed in petri dishes filled with Columbia agar supplemented with pig serum and different concentrations of the drugs. Cell sensitivity assays demonstrated low toxicity of beauvericin against primary human fibroblast skin cells. At 0.5 and 5 mM, beauvericin showed higher activity against adults and eggs of S. scabiei compared to dimpylate and ivermectin. These results revealed that the use of beauvericin is promising and might be considered for the treatment of S. scabiei infection.

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Section: Discussionmentioning

confidence: 99%

In Vitro Activity of Beauvericin against All Developmental Stages of Sarcoptes scabiei

Khoury

Nemer

et al. 2020

Antimicrob Agents Chemother

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“…The findings obtained by Aussy et al. support this recommendation: taking the medication with a meal was associated with a more than four‐fold increase in treatment failure .…”

Section: Discussionmentioning

confidence: 73%

Application errors associated with topical treatment of scabies: an observational study

Nemecek¹,

Stockbauer²,

Lexa³

et al. 2020

J Deutsche Derma Gesell

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Summary Background In recent years, there has been a significant increase in scabies infestations throughout German‐speaking countries. Given the high frequency of treatment failures, the question arises as to whether topical permethrin treatment is always performed correctly. Patients and methods Our department uses a fluorescent test cream to teach patients on how to correctly apply topical permethrin. In the context of a prospective observational study of 21 patients, we systematically assessed and analyzed potential application errors. Results None of the participants succeeded in adequately applying the cream to the entire skin as previously instructed. The median number of regions left untreated was six (minimum: 2; maximum: 18), which included a median body surface area of 6 % (minimum: 2 %; maximum: 30 %). With regard to predilection sites of scabies, the ankles were left untreated in 62 % of cases, followed by the interdigital spaces (toes) (33 %) and the sacral region (24 %). All patients considered the pretreatment training to be very useful. Conclusions The present findings clearly demonstrate potential shortcomings when it comes to the application of topical antiscabies treatment. This may provide a (potentially underestimated) explanation for the large number of reports on treatment failures in this regard, which falsely suggest potential treatment resistance.

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“…In conclusion, Aussy et al . have delivered a significant contribution to developing an understanding of treatment failure in an outpatient setting in France.…”

mentioning

confidence: 97%

“…This issue of the BJD includes an observational study from France which explores predictors of treatment failure among outpatients diagnosed with scabies, the first to do so in an ambulatory setting.…”

mentioning

confidence: 99%