Abstract:Tooth loss represents a diffused pathologic condition affecting the worldwide population. Risk factors have been identified in both general features (smoking, diabetes, economic status) and local tooth-related factors (caries, periodontitis). In this retrospective study, we examined the data of 366 patients with a large number of remaining teeth (≥25) undergoing maintenance therapy in order to identify specific risk factors for tooth loss. The number of remaining teeth, number of non-vital teeth, and number of… Show more
“…Other studies reported molar loss in general, which may have been extracted owing to the presence of apical lesions, root fractures or prosthodontic considerations, in addition to periodontal reasons. Endodontically treated molars tend to increase the endodontium‐related risk of loss (Kato et al, 2021; Kawahara et al, 2021). None of the included studies reported data on combined endo‐periodontal lesions, the clinical diagnosis and treatment of which continue to pose a challenge.…”
AimThis systematic review and meta‐analysis aimed to determine the survival of periodontally treated molars during maintenance care and identify the risk factors associated with molar loss among patients with periodontitis who received professional periodontal therapy and maintenance.Materials and MethodsLongitudinal studies with a minimum follow‐up duration of 5 years published until 28 August 2023 were retrieved from the following databases: the Cochrane Library, Embase, MEDLINE and Web of Science. All included studies reported data on molar retention. Meta‐analysis was performed using Review Manager 5.4. A modified version of the Newcastle–Ottawa Scale was used to evaluate the study quality. Statistical results of analyses of the overall survival rate and molar loss are presented as estimated standardized mean differences, whereas the results of the analyses of risk factors are presented as risk ratios with 95% confidence intervals (95% CIs).ResultsFrom among the 1323 potentially eligible reports, 41 studies (5584 patients, 29,908 molars retained at the beginning of maintenance therapy, mean follow‐up duration of 14.7 years) were included. The pooled survival rate of the molars during maintenance therapy was 82% (95% CI: 80%–84%). The average loss of molars was 0.05 per patient per year (95% CI: 0.04–0.06) among the patients receiving long‐term periodontal maintenance (PM) therapy. Fifteen factors were examined in this meta‐analysis. Six patient‐related factors (older age, lack of compliance, smoking, bruxism, diabetes and lack of private insurance) and five tooth‐related factors (maxillary location, high probing pocket depth, furcation involvement, higher mobility and lack of pulpal vitality) were identified as risk factors for molar loss during maintenance therapy.ConclusionsThe findings of the present study suggest that the long‐term retention of periodontally compromised molars can be achieved. The average number of molars lost per decade was <1 among the patients receiving long‐term PM therapy. Older age, noncompliance, smoking, bruxism, diabetes, lack of private insurance coverage, maxillary location, furcation involvement, higher mobility, increase in the probing pocket depth and loss of pulpal vitality are strong risk factors for the long‐term prognosis of molars.
“…Other studies reported molar loss in general, which may have been extracted owing to the presence of apical lesions, root fractures or prosthodontic considerations, in addition to periodontal reasons. Endodontically treated molars tend to increase the endodontium‐related risk of loss (Kato et al, 2021; Kawahara et al, 2021). None of the included studies reported data on combined endo‐periodontal lesions, the clinical diagnosis and treatment of which continue to pose a challenge.…”
AimThis systematic review and meta‐analysis aimed to determine the survival of periodontally treated molars during maintenance care and identify the risk factors associated with molar loss among patients with periodontitis who received professional periodontal therapy and maintenance.Materials and MethodsLongitudinal studies with a minimum follow‐up duration of 5 years published until 28 August 2023 were retrieved from the following databases: the Cochrane Library, Embase, MEDLINE and Web of Science. All included studies reported data on molar retention. Meta‐analysis was performed using Review Manager 5.4. A modified version of the Newcastle–Ottawa Scale was used to evaluate the study quality. Statistical results of analyses of the overall survival rate and molar loss are presented as estimated standardized mean differences, whereas the results of the analyses of risk factors are presented as risk ratios with 95% confidence intervals (95% CIs).ResultsFrom among the 1323 potentially eligible reports, 41 studies (5584 patients, 29,908 molars retained at the beginning of maintenance therapy, mean follow‐up duration of 14.7 years) were included. The pooled survival rate of the molars during maintenance therapy was 82% (95% CI: 80%–84%). The average loss of molars was 0.05 per patient per year (95% CI: 0.04–0.06) among the patients receiving long‐term periodontal maintenance (PM) therapy. Fifteen factors were examined in this meta‐analysis. Six patient‐related factors (older age, lack of compliance, smoking, bruxism, diabetes and lack of private insurance) and five tooth‐related factors (maxillary location, high probing pocket depth, furcation involvement, higher mobility and lack of pulpal vitality) were identified as risk factors for molar loss during maintenance therapy.ConclusionsThe findings of the present study suggest that the long‐term retention of periodontally compromised molars can be achieved. The average number of molars lost per decade was <1 among the patients receiving long‐term PM therapy. Older age, noncompliance, smoking, bruxism, diabetes, lack of private insurance coverage, maxillary location, furcation involvement, higher mobility, increase in the probing pocket depth and loss of pulpal vitality are strong risk factors for the long‐term prognosis of molars.
“…Tooth loss is a common oral disease that is more common in the elderly population and is associated with age, smoking, economic status, poor diet, and various oral pathological factors ( 21 ). Evidence shows that tooth loss is related to oral health and cognitive function.…”
Section: Tooth Loss and Cognitive Dysfunctionmentioning
Oral environment deterioration results from a lack of self-cleaning ability in patients with cognitive dysfunction but is also a risk factor for cognitive dysfunction. Adverse oral conditions can be alleviated and improved through a self-management and medical examination. In this review, the epidemiological evidence of previous studies is integrated to highlight the relationship between periodontitis, tooth loss, oral flora, oral dysfunction and cognitive dysfunction, emphasizing the importance of oral health for cognition. The results show that poor oral condition is associated with cognitive impairment. Although many previous studies have been conducted, there is a lack of higher-level research evidence, different judgment criteria, and conflicting research results. There is a bidirectional relationship between oral health and cognitive dysfunction. A comprehensive analysis of the relationship between oral health and cognitive dysfunction that explores the relationship and takes measures to prevent cognitive dysfunction and control the progression of such diseases is warranted in the future.
Conventional direct pulp-capping materials induce pulp cells to secrete various biomolecules in pulp tissues that promote reparative dentin formation through induction of odontoblastic differentiation of dental pulp stem cells (DPSCs). However, these biomolecules sometimes induce bone-like dentin with poor sealing properties. Therefore, exploration of biomolecules that allow tight sealing by tubular reparative dentin is required. We recently reported that dopamine (DA) is involved in dentinogenesis. Hence, we investigated the effect of DA on odontoblastic differentiation of DPSCs and reparative dentin formation. Both tyrosine hydroxylase (TH), a DA synthetase, and DA were expressed in odontoblast-like cells in vivo. In vitro, their expression was increased during odontoblastic differentiation of DPSCs. Furthermore, TH-overexpressing DPSCs had promoted odontoblastic differentiation and DA production. Moreover, DA stimulation promoted their differentiation and induced tubular reparative dentin. These results suggest that DA produced by TH is involved in odontoblastic differentiation of DPSCs and has an inductive capacity for reparative dentin formation similar to primary dentin. This study may lead to the development of therapy to preserve vital pulp tissues.
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