Risk Factors for Tinnitus in a Population of Older Adults: The Blue Mountains Hearing Study

Sindhusake, Doungkamol; Golding, Maryanne; Newall, Philip; Rubin, George; Jakobsen, Kirsten; Mitchell, Paul

doi:10.1097/01.aud.0000100204.08771.3d

Cited by 172 publications

(205 citation statements)

References 31 publications

(28 reference statements)

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“…The incidence of tinnitus (64.4% and 72.5%, for men and women, respectively) in our study was higher when compared to other studies involving senior citizens (Rosenthall 20 to 42%; Nondahl, 5.7 to 8.2%; Sindhusake 30.3%) [32][33][34] . Such difference may be associated with the fact that we included in our study only elderly with one or more hearing complaints.…”

Section: Discussioncontrasting

confidence: 52%

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Estudo audiológico de uma população idosa brasileira

Carmo

Silveira

Marone

et al. 2008

Rev. Bras. Otorrinolaringol.

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The Brazilian elderly population is growing, and already represents 8,6% of our total population. Environmental factors, lifestyle, gender and genetics impact the development of presbycusis, which reduces quality of life. Aim: investigate audiologic and vestibular complaints in the elderly; perform tonal audiometry and check to see if there are differences between genders. Study: Cross-sectional clinical prospective study. Materials and Methods: 320 elderly patients (160 men and 160 women) were submitted to audiologic interview and tonal audiometry. The results were statistically analyzed by the following methods: ANOVA, Mann-Whitney and Chi-Squared. Results: audiologic and vestibular complaints (hearing loss, tinnitus, ear fullness, dizziness) were similar between the genders (except for dizziness: p<0,05); tonal audiometry showed a significant difference, with hearing loss in the high frequencies among men; and among women the curves were descending and flat. These results were statistically significant (P<0,001). Conclusion: our results lead us to conclude that, when the genders are compared, hearing loss in the elderly has similar symptoms; however, there are significant differences in tonal audiometry.

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Section: Discussioncontrasting

confidence: 52%

“…In the study carried out by Nondahl et al 33 , prevalence varied between 5.7 and 8.2% of the elderly patients. Now, Sindhusake et al 34 studied 2015 elderly and they found a prevalence of 30.3%, and 48% of them had bilateral complaints, and only 6% received some treatment for this problem.…”

Section: Introductionmentioning

confidence: 99%

Estudo audiológico de uma população idosa brasileira

Carmo

Silveira

Marone

et al. 2008

Rev. Bras. Otorrinolaringol.

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“…Often, but not always, tinnitus is associated with a certain measure of hearing loss mostly of the upper part of the range of hearing (Henry et al, 1999). Hearing loss represents the most prevalent risk factor for tinnitus (Sindhusake et al, 2003; Moller, 2007). …”

Section: Introductionmentioning

confidence: 99%

Structural changes of the corpus callosum in tinnitus

Diesch

Schummer

Krämer

et al. 2012

Front. Syst. Neurosci.

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Objectives: In tinnitus, several brain regions seem to be structurally altered, including the medial partition of Heschl's gyrus (mHG), the site of the primary auditory cortex. The mHG is smaller in tinnitus patients than in healthy controls. The corpus callosum (CC) is the main interhemispheric commissure of the brain connecting the auditory areas of the left and the right hemisphere. Here, we investigate whether tinnitus status is associated with CC volume. Methods: The midsagittal cross-sectional area of the CC was examined in tinnitus patients and healthy controls in which an examination of the mHG had been carried out earlier. The CC was extracted and segmented into subregions which were defined according to the most common CC morphometry schemes introduced by Witelson (1989) and Hofer and Frahm (2006). Results: For both CC segmentation schemes, the CC posterior midbody was smaller in male patients than in male healthy controls and the isthmus, the anterior midbody, and the genou were larger in female patients than in female controls. With CC size normalized relative to mHG volume, the normalized CC splenium was larger in male patients than male controls and the normalized CC splenium, the isthmus and the genou were larger in female patients than female controls. Normalized CC segment size expresses callosal interconnectivity relative to auditory cortex volume. Conclusion: It may be argued that the predominant function of the CC is excitatory. The stronger callosal interconnectivity in tinnitus patients, compared to healthy controls, may facilitate the emergence and maintenance of a positive feedback loop between tinnitus generators located in the two hemispheres.

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“…Estimates suggest that approximately 10-14% of people in the general population and up to 30% of the subjects in a population aged 55 years and older report the presence of tinnitus [1,2]. hearing loss can be the basis for the selection of candidate genes.…”

Section: Introductionmentioning

confidence: 99%

Analysis of inner ear potassium recycling genes as potential factors associated with tinnitus

Pawełczyk¹,

Rajkowska²,

Kotyło³

et al. 2012

International Journal of Occupational Medicine and Environmental Health

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Tinnitus is defined as a perception of sound in the absence of an external acoustic stimulus. Several factors are known to influence tinnitus, e.g. hearing loss, noise exposure, age, and hypertension. As only certain individuals develop tinnitus in the presence of the above risks and in approximately 50% of cases tinnitus is not attributed to any particular cause, the question arose whether this inter-individual susceptibility to tinnitus could be explained by the influence of genetic factors. Objectives: To test the hypothesis that genetic variability in genes of the potassium recycling pathway is associated with increased susceptibility to tinnitus. Materials and Methods: The study group consisted of 626 subjects exposed to occupational noise (128 with tinnitus and 498 without tinnitus). 99 single nucleotide polymorphisms were investigated in 10 genes involved in the potassium recycling pathway in the inner ear, previously selected as putative noise-induced hearing loss (NIHL) candidate genes. Results: Nominally significant associations were obtained for 2 variants in KCNE1 (potassium voltage-gated channel, Isk-related family, member 1) and SLC12A2 (solute carrier family 12, member 2) genes. The first gene contributed to tinnitus that developed independently of hearing loss, while the second one was associated with increased susceptibility to noise-induced hearing loss. Conclusions: Present findings lend support to the notion of potassium recycling pathway genes as possible risk modifiers of tinnitus in individuals with and without hearing loss. Due to the lack of replication in other independent populations these results should be seen as suggestive.

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Risk Factors for Tinnitus in a Population of Older Adults: The Blue Mountains Hearing Study

Abstract: Interventions aimed at reducing age-related hearing loss, particularly by reducing excessive work-related noise exposure, and the effective, timely treatment of ear-related infections, may all decrease the risk of tinnitus.

Cited by 172 publications

References 31 publications

Estudo audiológico de uma população idosa brasileira

Estudo audiológico de uma população idosa brasileira

Structural changes of the corpus callosum in tinnitus

Analysis of inner ear potassium recycling genes as potential factors associated with tinnitus

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