Risk Factors for Thrombosis Development in Mexican Patients

Zavala-Hernández, César; Hernández-Zamora, Edgar; Martínez-Murillo, Carlos; Majluf‐Cruz, Abraham; Vela‐Ojeda, Jorge; Garcı́a-Chávez, Jaime; Reyes‐Maldonado, Elba

doi:10.1016/j.avsg.2015.05.035

Cited by 8 publications

(7 citation statements)

References 45 publications

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“… 27 – 29 Approximately 90% patients with tumors have abnormal coagulation function, and the blood is hypercoagulable and easily forms venous thrombosis. 30 , 31 Especially in chemotherapy of malignant tumors, chemotherapy drugs cause damage to the venous wall, which is an important cause of DVT in patients. 32 Inpatients are also prone to DVT of the lower extremities because of prolonged bed rest during hospitalization.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of stability of deep venous thrombosis of the lower extremities using Doppler ultrasound

et al. 2020

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Objective This study aimed to assess using Doppler ultrasound for analyzing stability of deep venous thrombosis (DVT) of the lower extremities. Methods Patients with DVT of the lower extremities who were treated from August 2017 to December 2019 were selected. The patients were divided into stable and unstable groups according to whether thrombus was collected in a filter. Related ultrasound and blood test results were analyzed and compared. Results A total of 126 patients with DVT of the lower extremities were included, of whom 74 were in the stable group and 52 were in the unstable group. There were significant differences in the prothrombin time (PT), and lipoprotein alpha, D-dimer, and triglyceride levels between the groups. D-dimer levels >2800 ug/L, smoking, history of venous thrombosis, PT >13.15 s, and body mass index >24.45 kg/m2 were independent risk factors for stability of DVT of the lower extremities. The area under the curve with combined detection of DVT was significantly higher than that for body mass index, PT, and D-dimer alone. Conclusion Doppler ultrasound may be reliable for analyzing the stability of DVT of the lower extremities. Related strategies targeting risk factors are required for reducing DVT of the lower extremities.

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Section: Discussionmentioning

confidence: 99%

Evaluation of stability of deep venous thrombosis of the lower extremities using Doppler ultrasound

et al. 2020

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“…PCR measures of the Factor V Leiden, prothrombin, MTHFR mutations and serologic measures of activated protein C resistance [ 16 , 17 ], antigenic proteins antithrombin III, C, total S, free S, homocysteine, factors VIII and XI [ 18 , 19 ], the lupus anticoagulant, and anticardiolipin antibodies were carried out using established methods [ 20 – 22 ].…”

Section: Methodsmentioning

confidence: 99%

Hospitalization for pulmonary embolism associated with antecedent testosterone or estrogen therapy in patients found to have familial and acquired thrombophilia

et al. 2016

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BackgroundIn patients hospitalized over a 4 year period for pulmonary embolism (PE), we assessed relationships of testosterone (TT) and estrogen therapy (ET) anteceding PE in patients found to have familial-acquired thrombophilia.MethodsFrom 2011 through 2014, 347 patients were hospitalized in Cincinnati Mercy Hospitals with PE. Retrospective chart review was used to identify patients receiving TT or ET before PE; coagulation studies were done prospectively if necessary.ResultsPreceding hospitalization for PE, 8 of 154 men (5 %) used TT, and 24 of 193 women (12 %) used ET. The median number of months from the initiation of TT or ET to development of PE was 7 months in men and 18 months in women. Of the 6 men having coagulation measures, all had ≥ 1 thrombophilia, and of the 18 women having measures of coagulation, 16 had ≥ 1 thrombophilia. The sensitivity of a previous history of thrombosis to predict PE was low, 25 % (2/8 men), 4 % (1/24 women).ConclusionsOf 154 men hospitalized for PE, 8 (5 %) used TT, and of 193 women, 24 (12 %) used ET. Our data suggests that PE is an important complication of TT in men and ET in women, in part reflecting an interaction between familial and acquired thrombophilia and exogenous hormone use.

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“…[18][19][20] Plasmatic measures of thrombophilia and hypofibrinolysis. Plasmatic measures of activated protein C resistance, 21,22 antigenic antithrombin III, protein C, total protein S, free protein S, homocysteine, factors VIII and XI, 23,24 the lupus anticoagulant, and anticardiolipin antibodies were carried out using established methods. [18][19][20] Serologic studies of PAI activity were not done.…”

Section: Laboratory Assessment Of Thrombophilia and Hypofibrinolysismentioning

confidence: 99%

Thrombophilia in Klinefelter Syndrome With Deep Venous Thrombosis, Pulmonary Embolism, and Mesenteric Artery Thrombosis on Testosterone Therapy: A Pilot Study

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Goldenberg

et al. 2016

Clin Appl Thromb Hemost

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We compared thrombophilia and hypofibrinolysis in 6 men with Klinefelter syndrome (KS), without previously known familial thrombophilia, who had sustained deep venous thrombosis (DVT)-pulmonary emboli (PE) or mesenteric artery thrombosis on testosterone replacement therapy (TRT). After the diagnosis of KS, TRT had been started in the 6 men at ages 11, 12, 13, 13, 19, and 48 years. After starting TRT, DVT-PE or mesenteric artery thrombosis was developed in 6 months, 1, 11, 11, 12, and 49 years. Of the 6 men, 4 had high (>150%) factor VIII (177%, 192%, 263%, and 293%), 3 had high (>150%) factor XI (165%, 181%, and 193%), 1 was heterozygous for the factor V Leiden mutation, and 1 was heterozygous for the G20210A prothrombin gene mutation. None of the 6 men had a precipitating event before their DVT-PE. We speculate that the previously known increased rate of DVT-PE and other thrombi in KS reflects an interaction between prothrombotic, long-term TRT with previously undiagnosed familial thrombophilia. Thrombophilia screening in men with KS before starting TRT would identify a cohort at increased risk for subsequent DVT-PE, providing an optimally informed estimate of the risk/benefit ratio of TRT.

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Risk Factors for Thrombosis Development in Mexican Patients

Cited by 8 publications

References 45 publications

Evaluation of stability of deep venous thrombosis of the lower extremities using Doppler ultrasound

Evaluation of stability of deep venous thrombosis of the lower extremities using Doppler ultrasound

Hospitalization for pulmonary embolism associated with antecedent testosterone or estrogen therapy in patients found to have familial and acquired thrombophilia

Thrombophilia in Klinefelter Syndrome With Deep Venous Thrombosis, Pulmonary Embolism, and Mesenteric Artery Thrombosis on Testosterone Therapy: A Pilot Study

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