Risk factors for three-month mortality after discharge in a cohort of non-oncologic hospitalized elderly patients: Results from the REPOSI study

Pasina, Luca; Cortesi, Laura; Tiraboschi, Mara Maria; Nobili, Alessandro; Lanzo, Giovanna; Tettamanti, Mauro; Franchi, Carlotta; Mannucci, Pier Mannuccio; Ghidoni, Silvia; Assolari, Andrea; Brucato, Antonio

doi:10.1016/j.archger.2017.10.016

Cited by 15 publications

(10 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A previous study [4] reported that three-month mortality after discharge was 5.4%, which was higher than in our study. However, the previous study included only 3,915 older people recruited from internal medicine and geriatric wards, of whom only 112 were bedridden [4]. The average age of those patients was older and comorbidities were more common.…”

Section: Mortalitycontrasting

confidence: 84%

“…Short-term mortality (within three months) has many crucial implications in planning diagnosis, therapies and overall management [16]. A previous study [4] reported that three-month mortality after discharge was 5.4%, which was higher than in our study. However, the previous study included only 3,915 older people recruited from internal medicine and geriatric wards, of whom only 112 were bedridden [4].…”

Section: Mortalitycontrasting

confidence: 70%

“…One previous study found that being permanently bedridden was an independent predictor of 30-day mortality in geriatric patients [23]. Being bedridden for the whole stay in hospital was also a risk factor for three-month mortality after hospital discharge [4]. Our study, however, included any patients who stayed in bed for at least 24 hours after admission and we recorded total time spent bedridden before and during hospitalization.…”

Section: Associated Risk Factors In Hospitalized Bedridden Patientsmentioning

confidence: 99%

“…A study of 498 hospitalized older patients (� 70 years old) found that low mobility and bedrest were common and associated with adverse outcomes such as decline in ability to perform activities of daily living, death and institutionalization [3]. A prospective cohort study among 3,915 hospitalized older patients in 102 Italian internal medicine and geriatric hospital wards found that being bedridden was a risk factor for shortterm mortality in non-oncological patients [4]. Another study [5] found that immobility was associated with risk of death in patients on invasive mechanical ventilation in an intensive care unit.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Factors associated with death in bedridden patients in China: A longitudinal study

Cao

Wang

et al. 2020

PLoS ONE

View full text Add to dashboard Cite

Background Immobility is common and associated with adverse outcomes in hospitalized patients, especially older people. However, the factors contributing to mortality in bedridden patients are not well known. This study aimed to estimate short-term mortality and analyze risk factors that affect the prognosis of bedridden patients. Methods This was a multicenter study in China involving 23,738 patients admitted to 25 hospitals between November 2015 and June 2016. All-cause mortality was recorded for 90 days after enrollment regardless of whether death occurred before or after discharge. Socio-demographic and clinical information was obtained from an electronic database. Univariate and multivariate Cox regression analysis was used to identify factors associated with mortality.

show abstract

Section: Mortalitycontrasting

confidence: 84%

Section: Mortalitycontrasting

confidence: 70%

Section: Associated Risk Factors In Hospitalized Bedridden Patientsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Factors associated with death in bedridden patients in China: A longitudinal study

Cao

Wang

et al. 2020

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Hospitalisations among people with any type of dementia are associated with severe adverse outcomes (Watkin et al ., 2012), including functional decline (Pedone et al ., 2005), a long length of stay (LOS) (Möllers et al ., 2019a), high complication and mortality rates (Bail et al ., 2013; Reynish et al ., 2017; Lehmann et al ., 2018; Pasina et al ., 2018), a high rate of readmission (Pickens et al ., 2017; Lehmann et al ., 2018) and of NHP (Lehmann et al ., 2018). Hence, the question whether the use of ChEIs and the NMDA antagonist memantine may limit the detrimental effects of long and complex hospitalisations for people with dementia (PWD) is of high public health relevance.…”

Section: Introductionmentioning

confidence: 99%

Alzheimer's disease medication and outcomes of hospitalisation among patients with dementia

Möllers

Perna

Stocker

et al. 2019

Epidemiol Psychiatr Sci

View full text Add to dashboard Cite

Aims The use of Alzheimer disease medication for the treatment of dementia symptoms has shown significant benefits with regards to functional and cognitive outcomes as well as nursing home placement (NHP) and mortality. Hospitalisations in these patient groups are characterised by extended length of stays (LOS), frequent readmissions, frequent NHP and high-mortality rates. The impact of Alzheimer disease medication on the aforementioned outcomes remains still unknown. This study assessed the association of Alzheimer disease medication with outcomes of hospitalisation among patients with Alzheimer disease and other forms of dementia. Methods A dynamic retrospective cohort study from 2004 to 2015 was conducted which claims data from a German health insurance company. People with dementia (PWD) were identified using ICD-10 codes and diagnostic measures. The main predictor of interest was the use of Alzheimer disease medication. Hospitalisation outcomes included LOS, readmissions, NHP and mortality during and after hospitalisation across four hospitalisations. Confounding was addressed using a propensity score throughout all analyses. Results A total of 1380 users of Alzheimer disease medication and 6730 non-users were identified. The use of Alzheimer disease medication was associated with significantly shorter LOS during the first hospitalisations with estimates for the second, third and fourth showed a tendency towards shorter hospital stays. In addition, current users of Alzheimer disease medication had a lower risk of hospital readmission after the first two hospitalisations. These associations were not significant for the third and fourth hospitalisations. Post-hospitalisation NHP and mortality rates also tended to be lower among current users than among non-users but differences did not reach statistical significance. Conclusions Our results indicate that Alzheimer disease medication might contribute to a reduction of the LOS and the number of readmissions in PWD.

show abstract

Polypharmacy in older people: lessons from 10 years of experience with the REPOSI register

2018

Self Cite

View full text Add to dashboard Cite

As a consequence of population aging, we have witnessed in internal medicine hospital wards a progressive shift from a population of in-patients relatively young and mainly affected by a single ailment to one of ever older and more and more complex patients with multiple chronic diseases, followed as out-patients by many different specialists with poor integration and inevitably treated with multiple medications. Polypharmacy (defined as the chronic intake of five or more drugs) is associated with increased risks of drug-drug interactions and related adverse effects, prescription and intake errors, poor compliance, re-hospitalization and mortality. With this background, the Italian Society of Internal Medicine chose to start in 2008 a prospective register called REPOSI (REgistro POliterapie SIMI, Società Italiana di Medicina Interna) in internal medicine and geriatric hospital wards. The country wide register is an ongoing observatory on multimorbidity and polypharmacy in the oldest old, with the goal to improve prescription appropriateness and, thus to avoid potentially inappropriate medications. The main findings of the register, that has accrued so far, 7005 older patients throughout a 10 year period, are summarized herewith, with special emphasis on the main patterns of poor prescription appropriateness and related risks of adverse events.

show abstract

Risk factors for three-month mortality after discharge in a cohort of non-oncologic hospitalized elderly patients: Results from the REPOSI study

Cited by 15 publications

References 26 publications

Factors associated with death in bedridden patients in China: A longitudinal study

Factors associated with death in bedridden patients in China: A longitudinal study

Alzheimer's disease medication and outcomes of hospitalisation among patients with dementia

Polypharmacy in older people: lessons from 10 years of experience with the REPOSI register

Contact Info

Product

Resources

About