Risk Factors for the Progression of Endoscopic Barrett’s Epithelium in Japan: A Multivariate Analysis Based on the Prague C &amp; M Criteria

Akiyama, Tomoyuki; Inamori, Masahiko; Akimoto, Keiko; Iida, Hiroshi; Mawatari, Hironori; Endo, Hideki; Ikeda, Tamon; Nozaki, Yuichi; Yoneda, Kyoko; Sakamoto, Yasunari; Fujita, Koji; Yoneda, Masato; Takahashi, Hirokazu; Hirokawa, Satoru; Goto, Ayumu; Abe, Yasunobu; Kohno, Hiroyuki; Kobayashi, Noritoshi; Kubota, Kensuke; Saito, Satoru; Nakajima, Atsushi

doi:10.1007/s10620-008-0537-y

Cited by 28 publications

(43 citation statements)

References 27 publications

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“…These findings are consistent with previous reports from Japan indicating that SSBE is more common while LSBE is rarer, compared with observations reported in the United States and Western Europe [21,22]. The frequency of BE may be affected by differences in its definition, and particularly by whether the presence of intestinal metaplasia is essential for making the diagnosis.…”

Section: Discussionsupporting

confidence: 92%

“…In the present study, we selected control subjects from among outpatients who had undergone endoscopies for a health check-up during the same period and who had no endoscopically identified localized lesions in the upper gastrointestinal tract. Nonetheless, the prevalences of the endoscopic findings, including EE and BE, in the controls were similar to those described for Japanese populations in previous reports [21,22]. Hence, a bias in the selection of controls is unlikely, although a prospective cohort study is required to resolve this issue.…”

Section: Discussionsupporting

confidence: 81%

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Gastric surgery is not a risk factor for erosive esophagitis or Barrett's esophagus

Akiyama

Inamori

Akimoto

et al. 2010

Scandinavian Journal of Gastroenterology

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 81%

Gastric surgery is not a risk factor for erosive esophagitis or Barrett's esophagus

Akiyama

Inamori

Akimoto

et al. 2010

Scandinavian Journal of Gastroenterology

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“…1). 26,27 However, the different definitions used for the esophagogastric junction (EGJ) might, to a large extent, account for this discrepancy. Most studies conducted in Asia outside of Japan defined the proximal margin of gastric folds as the EGJ, whereas the Japanese studies used the distal margin of the palisade vessels as the EGJ landmark 35…”

Section: Lower Prevalence Of Barrett Esophagus In Asiamentioning

confidence: 99%

Barrett Esophagus in Asia: Same Disease with Different Pattern

Lee

Jeon

2014

Clin Endosc

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Barrett esophagus (BE) is considered to develop as a result of chronic gastroesophageal reflux disease (GERD) and to predispose to esophageal adenocarcinoma (EAC). However, the disease pattern of BE in Asia differs from that observed in the West. For example, in the West, the prevalence rates of BE and EAC have progressively increased, whereas although the prevalence rate of GERD is increasing in Asia, the prevalence rates of BE and EAC have remained low in most Asian countries. GERD, hiatal hernia, old age, male sex, abdominal obesity (visceral obesity), smoking, alcohol consumption, and kyphosis are known risk factors for BE in Asia, and most Asian patients have short-segment BE. Helicobacter pylori infection is more prevalent in Asia than in the West. We suggest larger studies with a prospective design be conducted to elaborate further the different patterns of BE in Asia.

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“…Simple obesity, as measured by the body mass index (BMI), has been reported as one of the strongest risk factors for GERD symptoms, erosive esophagitis and esophageal adenocarcinoma [6,7,8,9,10], while it still remains controversial whether it is also an independent risk factor for BE [11,12,13,14,15]. Several studies have examined the association between simple obesity and BE and inconsistent results have been reported, ranging from a significantly increased risk associated with a high BMI [11,12], to a significantly increased risk associated with a high BMI only in the presence of GERD symptoms [13], to no association at all [14].…”

Section: Simple Obesity and The Risk Of Bementioning

confidence: 99%

“…Several studies have examined the association between simple obesity and BE and inconsistent results have been reported, ranging from a significantly increased risk associated with a high BMI [11,12], to a significantly increased risk associated with a high BMI only in the presence of GERD symptoms [13], to no association at all [14]. Our retrospective cohort study in the Japanese general population showed that simple obesity is not a risk factor for BE; the evaluation of the association between BMI and BE may be limited by the small numbers of obese subjects in the Japanese general population (table 1) [15]. …”

Section: Simple Obesity and The Risk Of Bementioning

confidence: 99%

Visceral Obesity and the Risk of Barrett’s Esophagus

et al. 2011

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It still remains controversial whether simple obesity, as measured by the body mass index (BMI), is an independent risk factor for Barrett’s esophagus (BE). Recent studies have shown abdominal obesity, as defined by the waist circumference (WC) and the waist-to-hip ratio (WHR), to be a risk factor for BE, independent of the BMI, with the association between BMI and BE being no longer observed after adjustment for the WC and WHR. Moreover, visceral obesity, as directly measured by the surface area of the visceral adipose tissue (VAT) on abdominal CT images, has also been reported to have an association with the risk of BE. In addition to the mechanical effects of abdominal obesity, that is, increase of the intra- abdominal pressure by the large amount of adipose tissue, circulating factors secreted from the VAT, such as tumor necrosis factor-α, interleukin-6, leptin, and adiponectin, have also been proposed to be pathogenetically linked to BE and esophageal adenocarcinoma. Obesity is associated with the risk of BE, and this risk appeared to be mediated for the most part by abdominal obesity, especially visceral obesity. This raises several questions regarding the pathogenesis of obesity-related BE. Larger studies with prospective enrollment of patients are required for further examination of this issue.

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Risk Factors for the Progression of Endoscopic Barrett’s Epithelium in Japan: A Multivariate Analysis Based on the Prague C & M Criteria

Abstract: Forty-three percent of the total study population was diagnosed as having endoscopic Barrett's epithelium. During the follow-up period, 12.6% of the cases with Barrett's epithelium exhibited progression which was associated with aging and severe erosive esophagitis.

Cited by 28 publications

References 27 publications

Gastric surgery is not a risk factor for erosive esophagitis or Barrett's esophagus

Gastric surgery is not a risk factor for erosive esophagitis or Barrett's esophagus

Barrett Esophagus in Asia: Same Disease with Different Pattern

Visceral Obesity and the Risk of Barrett’s Esophagus

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