Risk factors for the occurrence and recurrence of acute cerebellar ataxia: a retrospective observational study

Zhu, Zezhang; Jiang, Weiwei; Li, Wei; Zhang, Jie; Lv, Xiaoyi; Lu, Changgui; Chen, Huan; Li, Hongxing; Xie, Hua; Tang, Jie; Du, Chong; Chen, Guanglin; Qian, Geng; Tang, Weibing

doi:10.1007/s10072-021-05362-4

Cited by 1 publication

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“…Although we have raised the possibility of a causal relationship between our patient's ataxia and the vaccine, it is important to consider a range of differential diagnoses before reaching any conclusion and to be aware of the level of certainty reached. Several possible etiologies, including infectious, inflammatory, genetic, and metabolic conditions, may lead to cerebellar ataxia in children [ 39 , 44 ]. In our patient, we performed a thorough clinical examination, along with laboratory and imaging studies, to exclude these other causes of ataxia.…”

Section: Discussionmentioning

confidence: 99%

Early acute cerebellar ataxia after meningococcal B vaccine: a case report of a 7-month-old infant and a review of the literature

et al. 2023

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Background Acute cerebellar ataxia (ACA) and acute cerebellitis represent disorders characterized by a para-infectious, post-infectious, or post-vaccination cerebellar inflammation. They are relatively common neurologic disorders among children, and may follow infections, or, more rarely, vaccinations. Few cases are instead described among infants. Although the immunization with meningococcal group B (MenB) vaccine has been associated with some neurological side effects, suspected ACA has been reported only once in the literature. Case presentation: we describe a 7-month-old female that presented ACA within 24 h from the MenB second dose vaccination. Extensive laboratory studies and magnetic resonance imaging excluded other causes. We then conducted an extended review of other vaccine related cases reported in the literature, focusing on the clinical characteristics of ACA and finding that ataxia and cerebellitis of para- or post-infectious cause are very rarely described in the first year of life. We collected 20 articles published in the last 30 years, including an amount of 1663 patients (1–24 years) with ACA. Conclusions: a very small number of suspected post-vaccinal ataxias has been described in recent years, compared to other causes, and vaccination remains an unquestionable medical need. Further research is needed to clarify the complex pathogenesis of this disorder and its eventual link with vaccinations.

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Section: Discussionmentioning

confidence: 99%