Risk factors for the occurrence and persistence of coronary aneurysms in Kawasaki disease

Jeon, Soo-kyeong; Kim, Geena; Ko, Hoon; Byun, Joung-Hee; Lee, Hyoung Doo

doi:10.3345/kjp.2018.07052

Cited by 9 publications

(9 citation statements)

References 21 publications

(35 reference statements)

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“…Although reports on new therapeutic options for initial IVIG-resistant patients, such as steroid, infliximab, or repeated IVIG are available, their effectiveness in reducing the prevalence of coronary aneurysm remains controversial. Jeon et al [9] demonstrated that their findings of a predictive risk factor are comparable to that of Ha et al [6], and that Harada scores did not have a significant effect on coronary aneurysm [9]. Lin et al [10] suggested that the coronary severity 1 month after KD onset is most crucial to the late coronary outcomes.…”

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confidence: 99%

“…In this issue of the Korean Journal of Pediatrics , Jeon et al [9] presented risk factors for the occurrence and persistence of coronary aneurysm in an interesting title in pediatrician’s, field of treatment that deals with KD. In this retrospective study, comprising 392 subjects, they reported the risk factors associated with early and late coronary artery outcomes in the patients treated for KD.…”

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confidence: 99%

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Predictive risk factors of coronary artery aneurysms in Kawasaki disease

Woo

2019

Korean J Pediatr

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confidence: 99%

Predictive risk factors of coronary artery aneurysms in Kawasaki disease

Woo

2019

Korean J Pediatr

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“…In some patients, fever may persist for weeks, prolonged fever is usually associated with a higher incidence of cardiac involvement. Jeon et al (24) enrolled 392 KD patients, and they found that CAL group showed signi cantly longer duration of the febrile stage than non-CAL group (7.2 ± 2.4 vs 5.3 ± 1.4 days, P 0.05).…”

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confidence: 98%

A Nomogram for Predicting Coronary Artery Lesions in Patients with Kawasaki Disease

Xuan,

Liu,

Yao

et al. 2023

Preprint

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Background As an acute systemic vasculitis, Kawasaki disease (KD) could develop coronary artery lesions (CAL) sometimes. However, its etiology was still unidentified. This study was to construct a predictive model based on clinical features and laboratory parameters, and then perform a rapid risk assessment of CAL. Methods We collected clinical and laboratory data retrospectively for all patients with KD who were hospitalized at our hospital from January 2016 to June 2023. All the patients were divided into CAL and non-CAL groups and then randomly assigned to a training set and a verification set. The independent risk variables of CAL were identified by univariate analysis and multivariate logistic regression analysis of the training set. These components were then utilized to build a predictive nomogram. Calibration curve and receiver operating characteristic curve were used to evaluate the performance of the model. The predictive nomogram was further validated in verification set. Results In the training set, 49 KD patients (19.9%) showed CAL. The proportion of fever days ≥ 10, C-reactive protein, total bilirubin were significantly higher, whereas age was younger, hemoglobin and albumin were lower in the CAL group than the non-CAL group. Younger age, fever days ≥ 10, higher C-reactive protein, lower hemoglobin and albumin were identified as independent risk factors. The nomogram constructed using these factors showed satisfactory calibration degree and discriminatory power (the area under the curve, 0.764). In the verification set, the area under the curve was 0.798. Conclusions Younger age, fever days longer than 10, lower hemoglobin and albumin levels, higher C-reactive protein levels were independent risk factors for CAL in KD patients. The predictive nomogram constructed utilizing 5 relevant risk factors could be conveniently used to facilitate the individualized prediction of CAL in KD patients.

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“…Furthermore, it is known that the platelet counts in KD patients are positively correlated with fever duration, and a longer inflammation period may be reflected in the increase in platelet counts (27). Jeon et al (28) observed that coronary artery aneurysms developed in 30 of 392 patients with KD within a month of diagnosis while in 20% they persisted even after 1 year of follow-up. High platelet counts and long-term fever are independent indicators of coronary artery aneurysm immediately after diagnosis.…”

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confidence: 99%

Utility of color Doppler echocardiography combined with clinical markers in diagnosis and prediction of prognosis of coronary artery lesions in Kawasaki disease

Xue

Wang

2020

Exp Ther Med

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The utility of color Doppler echocardiography in the diagnosis and follow-up of Kawasaki disease (KD) with coronary artery lesions (CAL) was analyzed, and the clinical parameters associated with the disease were examined. The general data, the color Doppler echocardiography data and the biochemical indexes from 102 children with KD were analyzed. The patients were divided into a CAL group and a non-coronary artery lesion (NCAL) group based on the presence or absence of CAL. The risk factors for CAL in KD were screened by univariate and multivariate analyses. Among the 102 cases, CAL complications were identified in 47 cases (46.08%). Compared with the NCAL group, the CAL group showed significantly higher incidences of fever duration, increased levels of N-terminal pro B-type natriuretic peptide (NT-proBNP), cardiac troponin I (cTnI), C-reactive protein (CRP), intravenous immunoglobulin resistance, erythrocyte sedimentation rate (ESR), platelets, alanine aminotransferase and aspartate aminotransferase, and significantly lower serum albumin levels (P<0.05). According to the multivariate analysis, fever duration [odds ratio (OR)=2.014], NT-proBNP (OR=3.004), cTnI level (OR=2.638), ESR (OR=1.461) and CRP elevation (OR=1.094) were predictors of CAL in KD. During convalescence, the left and right coronary artery diameters in the CAL group significantly decreased (P<0.05). Color Doppler echocardiography can observe the condition of coronary artery disease in patients with KD in real time and predicts its outcomes, which may be helpful for early diagnosis and long-term follow-up. Fever duration, cTnI, NT-proBNP and ESR levels were correlated with coronary artery diameter, of which the comprehensive use may be more accurate in determining the occurrence of CAL in KD.

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Risk factors for the occurrence and persistence of coronary aneurysms in Kawasaki disease

Cited by 9 publications

References 21 publications

Predictive risk factors of coronary artery aneurysms in Kawasaki disease

Predictive risk factors of coronary artery aneurysms in Kawasaki disease

A Nomogram for Predicting Coronary Artery Lesions in Patients with Kawasaki Disease

Utility of color Doppler echocardiography combined with clinical markers in diagnosis and prediction of prognosis of coronary artery lesions in Kawasaki disease

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