Risk factors for the diagnosis of colorectal cancer

Lewandowska, Anna; Rudzki, Grzegorz; Lewandowski, Tomasz; Stryjkowska-Góra, Aleksandra; Rudzki, Sławomir

doi:10.21203/rs.3.rs-422225/v1

Cited by 5 publications

(9 citation statements)

References 35 publications

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“…In the USA, alcohol consumption and smoking result in a one in five probability of CRC. 10 The risk increases with an increase in BMI with obese individuals having a higher risk. Compared to individuals with a BMI of 23, elderly individuals tend to have a 5–100% higher risk of CRC with a BMI of 30.…”

Section: Introductionmentioning

confidence: 99%

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Risk Factors for Colorectal Adenocarcinoma in an Indigenous Population in East Africa

Wismayer¹,

Kiwanuka²,

Wabinga³

et al. 2022

CMAR

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Introduction The incidence of colorectal cancer (CRC) is increasing in East Africa. Changes in lifestyle and dietary changes, particularly alcohol consumption, smoking, and consumption of cooked meats with a reduction in fibre in the diet may be responsible. The objective of our study was to determine the risk factors responsible for CRC in Uganda. Methods We recruited 129 participants with histologically proven colorectal adenocarcinoma and 258 control participants from four specialized hospitals in central Uganda from 2019 to 2021. Controls were block matched for age (±5 years) and sex of the case participants. The risk factor variables included; area of residence, tribe, body mass index (BMI), smoking, alcohol consumption and family history of gastrointestinal cancer. We used conditional or ordinal logistic regression to obtain crude and adjusted odds ratios for risk factors associated with CRC. Results In bivariate analysis, case participants were more likely to be associated with urban residence (cOR:62.11; p<0.001); family history of GI cancer (cOR: 14.34; p=0.001); past smokers (cOR: 2.10; p=0.080); past alcohol drinkers (cOR: 2.35; p=0.012); current alcohol drinkers (cOR: 3.55; p<0.001); high BMI 25–29.9 kg/m 2 (cOR: 2.49; p<0.001); and high BMI ≥30kg/m 2 (cOR: 2.37; p=0.012). In the multivariate analysis, urban residence (aOR: 82.79; p<0.001), family history of GI cancer (aOR: 61.09; p<0.001) and past smoking (aOR: 4.73; p=0.036) were independently associated with a higher risk of developing CRC. Conclusion A family history of gastrointestinal cancer was a risk factor for CRC. While population-based CRC screening may not be feasible in low income-countries, targeted CRC screening for first-degree relatives with CRC should be considered in East Africa. Molecular genetic studies need to be carried out to determine the role of hereditary factors in our population. Prevention strategies should be adopted to avoid smoking in our population which was associated with an increased risk of CRC.

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Section: Introductionmentioning

confidence: 99%

“…Compared to individuals with a BMI of 23, elderly individuals tend to have a 5–100% higher risk of CRC with a BMI of 30. 10 …”

Section: Introductionmentioning

confidence: 99%

Risk Factors for Colorectal Adenocarcinoma in an Indigenous Population in East Africa

Wismayer¹,

Kiwanuka²,

Wabinga³

et al. 2022

CMAR

View full text Add to dashboard Cite

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“…González et al [32] reported that colorectal cancer cases were increasing rapidly and that early diagnosis was very important to prevent the rapid increase in cancer cases and mortality rates. Lewandowska et al [33] emphasized that a sedentary lifestyle was an important risk factor for colorectal cancer. Our study is in parallel with the literature.…”

Section: Discussionmentioning

confidence: 99%

“…Being acquainted with this disease due to the previous history of colorectal cancer in another relative may lead to the concern of "I wonder if it is my turn" inpatient relatives. In the study conducted by Şentürk et al [34], it was reported that symptoms such as anxiety, depressive mood, and stress increased signi cantly in patients and their relatives during the cancer diagnosis process [33]. In the study of Erdoğan et al [35] it was determined that individuals caring for patients had concerns and doubts about the future, were not strong enough to x some situations, and experienced feelings such as fear, anxiety, sadness, stress, depression, and insecurity, and that the stress they experienced through medical treatments increased the mortality rate of caregivers in 5 years [35].…”

Section: Discussionmentioning

confidence: 99%

Determination of Risk Awareness and Knowledge Levels of First Degree Relatives of Colorectal Cancer Patients; The Case of Turkey

Temiz¹,

DOGER²,

Akın³

et al. 2022

Preprint

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Background Since genetic factor is an important factor in the occurrence of cancer in colorectal cancer, risk awareness and knowledge level of first-degree relatives of patients with colorectal cancer is very important in cancer prevention. Aim This study was conducted to determine the knowledge level of first-degree relatives of colorectal cancer patients about colorectal cancer and their awareness of colorectal cancer risk factors. Method This is a descriptive study. 251 patients undergoing chemotherapy with a diagnosis of colorectal cancer in a university hospital constituted the sample of the study. The data were obtained by face-to-face interview method using the Information Form and the Questionnaire for the Evaluation of Knowledge and Awareness Levels of Colorectal Cancers. Results The mean score of the Questionnaire for the Evaluation of Knowledge and Awareness Levels of Colorectal Cancers was found to be 10.61 ± 5.65. This score indicated that individuals undergoing chemotherapy with a family history of colorectal cancer had a moderate level of knowledge and awareness about colorectal cancer. Two-thirds of the participants reported that they had knowledge that diabetes, obesity, lifestyle, smoking and alcohol use increased the risk of colorectal cancer. Conclusion The results revealed that It was observed that elderly, low educated, male and rural-dwelling participants needed more education on improving the level of knowledge and awareness about colorectal cancers. Implications for Practice: In order to prevent colorectal cancer and reduce the burden of disease, it is seen that first-degree patient relatives need to be more conscious and educated.

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“…Colorectal cancer (CRC) is the third most common cancer worldwide and the lifetime risk of developing CRC is nearly 4% in all populations (1,2). The tumorigenesis and progression of CRC arise from different causes such as genetic instability, dysregulated genes (both tumor suppressors and oncogenes), and non-coding RNAs (microRNAs and long non-coding RNAs), the activation and inactivation of signaling pathways involved in tumorigenesis, as well as microenvironment (3,4).…”

Section: Introductionmentioning

confidence: 99%

Both a hypoxia-inducible EYA3 and a histone acetyltransferase p300 function as coactivators of SIX5 to mediate tumorigenesis and cancer progression

Chao¹,

Liu²

2022

Ann Transl Med

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Background: The transcription partners of eyes absent homologs and sine oculis homeobox homologs (EYA-SIX) contribute to tumorigenesis and progression of multiple cancers through mediating the expression of oncogenes and tumor suppressors. This study aimed to determine the roles of individual EYA-SIX partners and their downstream targets in colorectal cancer (CRC).Methods: Immunoblot and real-time quantitative polymerase chain reaction (RT-qPCR) were used to measure protein and gene expression levels. Cell Counting Kit-8 (CCK-8) assay, colony formation, cell invasion assays, and a tumor xenograft model were chosen to investigate tumor cell growth.Immunoprecipitation, mass spectrometry, and co-immunoprecipitation (Co-IP) experiments were performed to determine the assembly of the SIX5-associated complex. Chromatin immunoprecipitation (ChIP) assay was used to evaluate the occupancy of SIX5-associated complex on its target gene promoters. Results:We discovered that the hypoxia-induced EYA3 coupled with SIX5 and a histone acetyltransferase p300 to assemble a complex in CRC biopsies. The EYA3-SIX5-p300 complex was required for the transactivation of epidermal growth factor receptor (EGFR), vascular endothelial growth factor D (VEGFD), and five matrix metallopeptidases (MMPs), including MMP3, MMP7, MMP8, MMP21, and MMP26. The results of ChIP revealed that the EYA3-SIX5-p300 complex specifically bound to the promoters of EGFR/ VEGFD/MMPs. Disruption of the assembly of EYA3-SIX5-p300 complex decreased the expression of EGFR/VEGFD/MMPs, inhibiting CRC cell growth. Administration of EYA3 inhibitor (benzarone) in mice harboring tumor xenografts significantly inhibited tumor growth. Conclusions:The hypoxia-dependent EYA3-SIX5-p300 complex is involved in the pathogenesis of CRC through mediating EGFR/VEGFD/MMPs and targeting this complex may represent a new therapeutic strategy for CRC treatment.

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Risk factors for the diagnosis of colorectal cancer

Cited by 5 publications

References 35 publications

Risk Factors for Colorectal Adenocarcinoma in an Indigenous Population in East Africa

Risk Factors for Colorectal Adenocarcinoma in an Indigenous Population in East Africa

Determination of Risk Awareness and Knowledge Levels of First Degree Relatives of Colorectal Cancer Patients; The Case of Turkey

Both a hypoxia-inducible EYA3 and a histone acetyltransferase p300 function as coactivators of SIX5 to mediate tumorigenesis and cancer progression

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