Risk Factors for the Development of Delayed Graft Function in Deceased Donor Renal Transplants

Jushinskis, Janis; Trushkov, S.; Bicans, Janis; Suhorukov, V.; Shevelev, V.; Ziedina, Ieva; Rozental, Rafail

doi:10.1016/j.transproceed.2009.01.037

Cited by 23 publications

(15 citation statements)

References 7 publications

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“…The association of DGF and longer postoperative hospital stay has been reported in many previous studies [27][28][29][30][31][32] . Furthermore, Salazar et al also have reported the association of DGF with prolonged postoperative ICU stay 27 .…”

Section: Discussionmentioning

confidence: 82%

Recipient Pre-Operative Neutrophil Lymphocyte Ratio Better Predicts Delayed Graft Function than Platelet Lymphocyte Ratio in Donation after Brain Death Kidney Transplantation

Baral

Yang²,

Katwal³

et al. 2019

Med. J. Pokhara Acad. Health Sci.

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Background: Neutrophil lymphocyte Ratio (NLR) and Platelet lymphocyte Ratio (PLR) are an indicator of the status of inflammation. The objective of this study was to evaluate the relationship between recipient pre-operative Neutrophil lymphocyte Ratio (NLR) and Platelet lymphocyte Ratio (PLR) with delayed graft function in the kidney transplant patient. Methods: The preoperative full blood count, data regarding patient demographics and postoperative graft function was retrospectively evaluated from the database of our institution. All statistical calculations were carried out using SPSS 20.0 version (SPSS Inc., Chicago, IL, USA). A p-value<0.05 was considered statistically significant. Results: 289 patients were included in this study. DGF occurred in 33 cases. Elevated preoperative NLR had a sensitivity of 75.75% and specificity of 76.56% whereas elevated preoperative PLR had a sensitivity of 72.72% and specificity of 58.20% for predicting DGF. The area under the ROC curve was found to be 0.762 and 0.655 for NLR and PLR, respectively. Multivariate analysis showed NLR>3.5 and PLR>120 independently responsible for DGF. Conclusion: Recipient preoperative NLR and PLR can predict the occurrence of DGF following DBD renal transplantation. In addition, NLR is better than PLR in predicting DGF. DGF prolongs the total ICU and in-hospital stay.

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Section: Discussionmentioning

confidence: 82%

Recipient Pre-Operative Neutrophil Lymphocyte Ratio Better Predicts Delayed Graft Function than Platelet Lymphocyte Ratio in Donation after Brain Death Kidney Transplantation

Baral

Yang²,

Katwal³

et al. 2019

Med. J. Pokhara Acad. Health Sci.

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“…Various factors may be involved. A reduction in CIT may contribute to avoid this complication , but there are hemodynamic changes induced by ASK's transplantation in infants. Salvatierra et al.…”

Section: Discussionmentioning

confidence: 99%

“…Various factors may be involved. A reduction in CIT may contribute to avoid this complication (18), but there are hemodynamic changes induced by ASK's transplantation in infants. Salvatierra et al (17) documented the blood flow in the Ao and renal arteries of children below 16 kg haemodynamically stable and well hydrated who received kidneys from adults.…”

Section: Discussionmentioning

confidence: 99%

Vascular anastomosis for paediatric renal transplantation and new strategy in low‐weight children

Gomes

Nogueira

Camargo

et al. 2014

Pediatric Transplantation

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The technical aspects of RT in low-weight children should be specific, particularly with regard to VA. This retrospective study assesses the main VA options in paediatric RTs and proposes a new strategy for renal artery trajectory when using the Ao and the right iVC. The sample included 81 patients and was categorized into a group of children weighing <16 kg and the other group of children weighing 16 kg or more. The smaller children received the graft predominantly on the Ao and iVC (63%); however, the VA options varied in children weighing more than 16 kg, with anastomoses predominantly to the common iliac vessels (46%). In the first group, when the Ao was the selected vessel for anastomosis on the right side, the trajectory adopted for the transplanted kidney artery was posterior to the iVC. This strategy may reduce the risk of compression of the iVC by the renal artery of the donor kidney and may reconstitute the normal anatomy of the renal artery. Moreover, it did not represent a risk factor for graft loss in this sample.

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“…Considering the negative impact of delayed graft function on the early post-transplant results (continuation of dialysis, increasing number of acute rejections, increased hospitalisa- (Grino et al, 1994;Cravedi et al, 2005;Jushinskis et al, 2009;Lodhi et al, 2012). However the permanent shortage of donor organs forces to extend the criteria for organ donation: to use marginal donors, donors after cardiocirculatory death, including donors in the 3rd and 4th category according to Maastricht criteria (Koostra et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

Delayed Renal Graft Function in the Early Post-Transplant Period and its Impact on the Late Post-Transplant Results

Jušinskis¹,

Amerika²,

Maļcevs³

2013

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences

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Delayed renal graft function (DGF) is a frequent complication with negative impact on the course of early post-transplantation period. The data concerning the impact on the late results are contradictory. This study describes results of 5-year follow-up of 248 recipients after deceased donor renal transplantation. All patients were divided into two groups: with delayed graft function (DGF, n = 53) and immediate graft function, considered as the control group (IGF, n = 195). We evaluated factors that were associated with development of DGF and its impact on the survival of graft and recipient, and frequency of acute rejections and chronic dysfunctions. The rate of observed DGF was 21.4%. Its development was associated with the following factors: age of recipient and their weight, age of donor and their body mass index, high frequency of asystole/hypotension in donors prior to organ explantation (P < 0.05 for all), and longer time of cold ischemia (P = 0.058). The DGF group had higher rate of acute rejections (P < 0.001), and also lower 1.5 and 5-year graft survival and 1.5-year patient survival (P < 0.05 for all). The conclusion is that DGF has negative impact on the survival of renal grafts and patients, especially during the first 1.5 years after transplantation.

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Risk Factors for the Development of Delayed Graft Function in Deceased Donor Renal Transplants

Cited by 23 publications

References 7 publications

Recipient Pre-Operative Neutrophil Lymphocyte Ratio Better Predicts Delayed Graft Function than Platelet Lymphocyte Ratio in Donation after Brain Death Kidney Transplantation

Recipient Pre-Operative Neutrophil Lymphocyte Ratio Better Predicts Delayed Graft Function than Platelet Lymphocyte Ratio in Donation after Brain Death Kidney Transplantation

Vascular anastomosis for paediatric renal transplantation and new strategy in low‐weight children

Delayed Renal Graft Function in the Early Post-Transplant Period and its Impact on the Late Post-Transplant Results

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