Risk Factors for the Development of New-Onset Diabetes Mellitus in a Living Related Renal Transplant Program

Bora, Girdhar S.; Guleria, Sandeep; Reddy, Vemuru Sunil K; Tandon, Nikhil; Gupta, Nidhi; Gupta, Satish Chand; Bhowmik, D

doi:10.1016/j.transproceed.2010.10.008

Cited by 17 publications

(10 citation statements)

References 11 publications

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“…New onset diabetes after renal transplantation remains an Achilles heel in the long-term patient survival in renal transplant recipients. Incidence of NODAT in this study was 26.6% compared to 16-30% in other studies [5,6]. The cumulative incidence of NODAT in this study was 8.3%, 19.1% and 25% at 3, 6 and 12 months respectively whereas the USRDS data [4] showed 9.1%, 16% and 24% at 3, 12 and 36 months respectively.…”

Section: Discussioncontrasting

confidence: 59%

New Onset Diabetes after Transplant – Risk Factors, Clinical Profile and Outcome

Sakthirajan

Dhanapriya

Dineshkumar

et al. 2018

IDCD

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Background: New onset diabetes after transplant (NODAT) remains one among the significant threats to both renal allograft and patient survival. The aim of this study was to analyse the clinical profile and risk factors for NODAT.Methods: This prospective observational study involved patients who underwent renal transplantation in our centre between 2010 and 2015.Results: During the mean follow up period of 18 ± 6 months, incidence of NODAT was 26.6% and the cumulativeincidence was highest in the first year after transplant. Recipient age, pre transplant impaired fasting glucose, Hepatitis C virus (HCV) infection, family history of diabetes, tacrolimus, post transplant hypertriglyceridemia and metabolic syndrome were found to be statistically significant risk factors for NODAT. In Cox multivariate regression analysis, age and family history of diabetes were found to be independent risk factors for NODAT. Fasting C-peptide level underlines insulin resistance as predominant mechanism for NODAT in two third of patients. There were higher incidence of urinary tract infection in the NODAT patients. NODAT was found to be an independent risk factor for fungal infection and 10 year cardiovascular risk in the renal recipients. There was no significant impact of NODAT on short term graft and patient survival.Conclusion: Age, pre-transplant fasting blood glucose, family history of diabetes, HCV infection and tacrolimus were found to be the important risk factors, with insulin resistance as the predominant mechanism for NODAT.

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Section: Discussioncontrasting

confidence: 59%

New Onset Diabetes after Transplant – Risk Factors, Clinical Profile and Outcome

Sakthirajan

Dhanapriya

Dineshkumar

et al. 2018

IDCD

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“…In a study conducted by Valderhaug TG et al, posttransplant diabetes mellitus (PTDM) was reported in 14% patients [16]. In Indian studies, the incidences of NODAT were [17][18][19]. So there has been wide variation among incidence and in our study, the incidence of NODAT is 24%.…”

Section: Discussionsupporting

confidence: 47%

An observational prospective study to evaluate the outcomes of new onset diabetes after renal transplantation (NODAT) in a tertiary care centre in eastern India

Kumar

Sanyal

Das

et al. 2020

Diabetes Research and Clinical Practice

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“…The difference in age at transplantation between the two groups was not as great as described by Harrichund et al but still is significant [24]. Many previous studies also described age as a significant risk factor for the development of NODAT [11,12,16,17,19,26]. The mean age at transplantation of 40 years, combined with the fact that half of the patients developed NODAT within one year after transplantation, probably explains why the average age at diagnoses of NODAT in this study was 41 years.…”

Section: Discussionmentioning

confidence: 79%

“…In a UK study the incidence ranged from 15% to 20% [11]. The incidences are very similar in most studies [11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 89%

New onset diabetes after transplantation in renal transplant recipients at Tygerberg Hospital

Bapoo

Nel

2014

AJN

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New Onset Diabetes after Transplantation (NODAT) is a common complication of renal transplantation worldwide. However, there is very little data available regarding this condition in Sub-Saharan Africa. This study was therefore conducted in order to determine the incidence of NODAT and its associated risk factors in a South African renal transplant population. A retrospective analysis was conducted on 221 patients who underwent renal transplants at Tygerberg Hospital during the period January 1st 1995 to December 31st 2008.

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Risk Factors for the Development of New-Onset Diabetes Mellitus in a Living Related Renal Transplant Program

Cited by 17 publications

References 11 publications

New Onset Diabetes after Transplant – Risk Factors, Clinical Profile and Outcome

New Onset Diabetes after Transplant – Risk Factors, Clinical Profile and Outcome

An observational prospective study to evaluate the outcomes of new onset diabetes after renal transplantation (NODAT) in a tertiary care centre in eastern India

New onset diabetes after transplantation in renal transplant recipients at Tygerberg Hospital

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