Risk factors for systemic inflammatory response syndrome after radical prostatectomy for prostate cancer: A prospective study

Abstract

Aim Exploring the risk factors for systemic inflammatory response syndrome in prostate cancer patients after radical surgery, establishing a risk warning model, and validating it. Methods A prospective selection was conducted on 309 patients who underwent radical prostatectomy in our hospital from March 2022 to March 2024. They were divided into two groups based on whether SIRS occurred after surgery: the SIRS group (n =46) and the non-SIRS group (n =263). Logistic regression analysis was performed on possible related factors to construct a column chart risk model. Internal validation of the column chart model for predicting postoperative SIRS was performed using the Bootstrap method with 1000 repeated samples. Results The results of multivariate logistic regression analysis showed that operative time, diabetes mellitusm, preoperative indwelling catheterization, urinary catheter retention time, pathologic diagnosis (OR ＞ 1, P ＜0.05). A column chart prediction model was established based on the risk factors affecting postoperative SIRS, and internal validation was performed using bootstrap method with 1000 repeated samples. The predicted values of the calibration curve were basically consistent with the actual values, and the Hosmer Lemeshow goodness of fit test was performed χ2 = 11.851, P = 0.158, the area under the ROC curve is 0.844 (95%CI: 0.792-0.897). Conclusions The occurrence of SIRS in prostate cancer patients after radical surgery is influenced by multiple factors, and the risk warning model established based on these factors has good predictive performance.