Risk Factors for Surgical Wound Infection in HIV-Positive Patients Undergoing Surgery for Orthopaedic Trauma

Abalo, Anani; Patassi, Akouda; James, Yaovi Edem; Walla, A; Sangaré, A.; Dossim, Assang

doi:10.1177/230949901001800218

Cited by 41 publications

(46 citation statements)

References 22 publications

(32 reference statements)

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“…Abalo et al [18], at a median follow-up period of 27 months (range 19-41 months), demonstrated very high incidence of late implant sepsis (39%) in 36 HIV-positive patients. Lukhele et al reported a case of late implant sepsis at 4 years in a seropositive patient who had previously undergone spine stabilization surgery.…”

Section: Discussionmentioning

confidence: 98%

Late implant sepsis after fracture surgery in HIV positive patients

Graham

Bates

Mkandawire

et al. 2015

Injury

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Section: Discussionmentioning

confidence: 98%

Late implant sepsis after fracture surgery in HIV positive patients

Graham

Bates

Mkandawire

et al. 2015

Injury

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“…Among 39 patients with HIV undergoing implant surgery, there were 6 cases of wound infection, with 5 cases resolving after antibiotics and 1 case progressing to a deep chronic infection [19,20]. A study of 36 patients with HIV undergoing orthopedic trauma surgery identified 14 cases of postoperative wound infection, of which 12 resolved after debridement and antibiotics and 2 progressed to chronic osteomyelitis [21]. Among 34 patients with HIV who underwent 44 total hip arthroplasties, there were 2 deep infections identified at 59 and 64 months postoperatively, with both resolving after revision surgery with extensive debridement and the placement of an antibiotic spacer [11].…”

Section: Discussionmentioning

confidence: 99%

Does HIV Infection Increase the Risk of Short-Term Adverse Outcomes Following Total Knee Arthroplasty?

Boylan

Basu

Naziri

et al. 2015

The Journal of Arthroplasty

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“…This same definition of an ASEPSIS score of greater than 10 was used by the Malawi group [31]. However, the definition used in the other studies was not consistent [32,24,[33][34][35][36][37].…”

Section: Closed Fracturesmentioning

confidence: 99%

“…Eight authors studied non-union in closed fractures, with a mix of prospective [48,50,53] and retrospective studies [35,54]. (Table 5) The rates of non-union were 0% in 26 HIV-positive ART naïve patients that were clinically and radiologically closed femoral fractures that had undergone intramedullary nailing, however the method of evaluation of non-union was not described.…”

Section:  Non-union In Closed Fracturesmentioning

confidence: 99%

Fracture management in HIV positive individuals: a systematic review

Wijesekera

Graham

Lalloo

et al. 2016

International Orthopaedics (SICOT)

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Purpose: Human immunodeficiency virus (HIV) infection could potentially play an important role in the management of fractures as they have been shown to affect fracture healing and the post-operative risk of implant sepsis.Methods: A systematic review of the relevant literature was performed on PubMed and Scopus databases. Twenty-six studies were identified, critiqued and analysed accordingly. No randomised controlled trials were identified.Results: HIV positivity was not shown to influence an individual's risk of early wound infection in operatively managed closed fractures. Thank you for your kind comments on our unique systematic review. We have responded to the reviewers and made the changes suggested. Authors' response Many thanks for your comments. The suggested references however interesting, does not seem to cater to this population of interest. The suggested first article focusses on myocardial complications in those undergoing arthroplasty. The second suggested article main emphasis is on spinal trauma and does not refer to the HIV population. Thus we have decided not to go forth inserting these references and no further actions were taken. We do think that these articles are useful and may be included in a future study.Reviewer #2: This is a nice review paper suggesting the well-known fact that there is a place in HIV patients to surgical fixation of fractures.However the authors should: 1) Explain in the "Introduction" and in the "Discussion" the meaning of ART and the new development in this mode of treatment and describe the change in morbidity and mortality in HIV patients" in the last few years and the relation of this change to their findings Authors' response Many thanks for your comments. We agree that a further explanation on ART should be included to the reader. This was included in the "Introduction." Clarification on the morbidity and mortality reduction since the introduction of ART in HIV infected patients was also included. Regarding discussing the new developments in ART, this is a whole topic in itself and beyond the scope of this review. However, we are currently finalising a similar systematic review focusing on the effect of ART on bone metabolism and fracture healing which we will submit for consideration for publication in your journal soon. Authors' action Powered by Editorial Manager® and ProduXion Manager® from Aries Systems CorporationThe following changes have been made; The introduction of Anti-Retroviral Therapy (ART) in 1997 altered the course and nature of patients infected with HIV by increasing the duration of asymptomatic infection and increasing life expectancy [2,3]. ART is a combination of medication given to those affected with the disease. This suppresses the viral load and improves the patient immunological status [4]. A 50% reduction in morbidity and mortality has been reported in those with a CD4 T-cell count of >500cells/mm3 and have been started on ART promptly [5,6]. However, despite near normal life expectancy, there is little evidence to...

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Risk Factors for Surgical Wound Infection in HIV-Positive Patients Undergoing Surgery for Orthopaedic Trauma

Abstract: Identification of risk factors may help minimise morbidity in HIV-positive patients.

Cited by 41 publications

References 22 publications

Late implant sepsis after fracture surgery in HIV positive patients

Late implant sepsis after fracture surgery in HIV positive patients

Does HIV Infection Increase the Risk of Short-Term Adverse Outcomes Following Total Knee Arthroplasty?

Fracture management in HIV positive individuals: a systematic review

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