Risk Factors for Spontaneous Abortion: A Preliminary Study on Saudi Women

Abstract

A preliminary case-control study was conducted on Saudi women to detect possible risk factors for spontaneous abortion (SA). Two hundred and twenty six consecutive women hospitalised for SA and 226 women admitted for normal delivery and used as controls, were studied. Women with SA were significantly older at menarche (Relative Risk (RR) = 3.2), more frequently married to blood-related husbands (RR = 2.1) and husbands older than 50 years (RR = 2.4). Number of previous abortions related linearly to the risk of aborting spontaneously in the next pregnancy. Compared to primigravidas, the RR was 3.2 if the outcome of the most recent pregnancy was SA, and 0.8 if it was a livebirth. A family history of SA was more common among cases (RR = 4.6). Spontaneous abortion was also associated with daily consumption of more than 150 mg of caffeine, abdominal trauma, infection and fever during pregnancy. No significant association, however, emerged with maternal age, social class, education, exposure to video display terminals, parity, use of contraception, diabetes or obesity. The application of these data in clinical practice and future research needs are discussed.

Caffeine intake during pregnancy and adverse birth outcomes: a systematic review and dose–response meta-analysis

“…The pooled estimate of relative risk from linear dose-response meta-analysis was 1.14 (95% CI: 1.10 to 1.19) per 100 mg/day of caffeine (P < .001) (figure 2A). Five of the six studies that could not be included in meta-analyses supported this direction of association, with all but one statistically significant [33][34][35][36][37], and the remaining study finding no evidence of any association [38].…”

Subchorionic Hematoma in Threatened Abortion: Sonographic Evaluation and Significance

“…This can be explained on the basis that the risk of abortion in a given pregnancy rises directly with the number of previous abortions. [17][18][19] The median value of 13.2 cm 2 was used as the cut-off point for small and large hematoma size in this study because of the positively skewed distribution (1.6171) of the data, since the median would be the appropriate measure of central tendency for this set of data on hematoma areas. Using this median value of 13.2 cm 2 as the cutoff value for small and large size hematoma, it was observed that large hematomas (≥13.2 cm 2 ) tended to occur more significantly in the second trimester (P=0.0094), even when there was a higher incidence of subchorionic hematoma (68.8%) in the first trimester.…”

Paternité tardive: un risque en matière de reproduction?

“…Astolfi et al [2] Rychtarikova et al [23] Slama et al [25] de La Rochebrochard et Thonneau [6] Gourbin et Wunsch [13] aI-Ansary et Babay [1] Ford et al [10] Selvin et Garfinkel [24] Resseguie [22] …”