Risk Factors for Septic Complications in Kidney Transplant Recipients

Żukowski, Maciej; Bohatyrewicz, Romuald; Biernawska, Jowita; Kotfis, Katarzyna; Zegan, M; Knap, R; Janeczek, M; Ziętek, Z

doi:10.1016/j.transproceed.2009.08.010

Cited by 6 publications

(3 citation statements)

References 4 publications

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“…However, it also used as premedication for a range of dermal conditions. Metamizole (Dipyrone) is generally classified as one of the non‐steroidal anti‐inflammatory drugs; however, in truth, it is a pro‐drug with analgesic, antipyretic, and spasmolytic effects . Due to its wide range of effects and potency, it is a widely used drug in medicine.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effects of some drugs on carbonic anhydrase enzyme purified from Kangal Akkaraman sheep in Sivas, Turkey

Koçyiğit

Daştan

Taslimi

et al. 2017

J Biochem & Molecular Tox

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In this study, carbonic anhydrase (CA) enzyme was purified and characterized from blood samples of Kangal Akkaraman sheep and inhibitory properties on certain antibiotics were examined. CA purification was composed of preparation of the hemolysate and conducting the Sepharose-4B-tyrosine-sulfanilamide affinity gel chromatography in having specific activity of 11626 EU mg −1 , yield of 14.40%, and 242.76-fold purification. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis was performed to assess the enzyme purity and a single band was observed. Some antibiotics were exhibited in vitro inhibition on the CA activity. IC 50 values of these inhibitors were calculated by plotting activity percentage. IC 50 values of certain drugs (dexamethasone; caffeine; metamizole sodium; tetramisol; ceftiofur HCl; ivermectin; tavilin 50; penokain G; neosym; and sulfamezathine) were found as 0. 38, 8.24, 285.53, 114.77, 5.33, 2.76, 27.58, 213.50, 208.28, and 36.60 M, respectively. K i values of different drugs on Kangal Akkaraman sheep blood CA activity were found in the range of 0.21 ± 0.038-266.64 ± 37.11 M.

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Section: Discussionmentioning

confidence: 99%

Inhibitory effects of some drugs on carbonic anhydrase enzyme purified from Kangal Akkaraman sheep in Sivas, Turkey

Koçyiğit

Daştan

Taslimi

et al. 2017

J Biochem & Molecular Tox

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“…the occurrence of acute interstitial nephritis is mostly a consequence of drug abuse and rare enough to still be subject of single case reports (16). (101).…”

Section: Renal Findingsmentioning

confidence: 99%

Metamizole: A Review Profile of a Well-Known “Forgotten” Drug. Part II: Clinical Profile

Nikolova

Petkova

Tencheva

et al. 2013

Biotechnology & Biotechnological Equipment

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“…[ 1 2 3 ] Patients who have received a renal transplant are also susceptible to infection, primarily as a result of immunosuppression but also due to a shorter ureter predisposing to pyelonephritis. [ 4 5 6 ] Pyrexia of unknown origin (PUO) is a particularly common scenario in this population. Conventional cross-sectional imaging may fail to localize the cause of the fever.…”

Section: Introductionmentioning

confidence: 99%

Is there a Role for Gallium-67 Citrate SPECT/CT, in Patients with Renal Impairment or Who are Renal Transplant Recipients, in Identifying and Localizing Suspected Infection?

2015

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To assess the added value of single-photon emission computed tomography/computed tomography (SPECT/CT) in patients with end-stage renal failure (ESRF) or renal transplant recipients in whom focal infection was suspected. Gallium-67 (Ga-67) citrate scintigrams of 18 patients (10 in ESRF and eight with renal transplants) were reviewed. Sites of abnormal uptake seen on the whole body and SPECT were noted. A SPECT/CT was also reviewed to see if additional information could be obtained. Imaging results were compared with the final diagnosis. Overall, 14 out of 18 (78%) patients had a proven cause to explain symptoms while four patients did not have a final cause identified. Infection was proven in the final diagnosis in 12 out of 14 (86%) patients. Of the 10 patients with ESRF, six had confirmed infection with the Ga-67 citrate study correctly identifying five out of six (83%) patients, and SPECT/CT providing additional information in four out of five (80%) patients. In the eight renal transplant recipients, six had a confirmed source of infection (all identified by the Ga-67 citrate study). SPECT/CT provided additional information in two out of six (33%) patients. Ga-67 citrate imaging had an overall sensitivity of 13/14 (93%), with one false negative. SPECT/CT provided an additional contribution in eight out of 18 (44%) patients by better defining the location/extent of infection and differentiating the physiological from the pathological uptake.

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Risk Factors for Septic Complications in Kidney Transplant Recipients

Cited by 6 publications

References 4 publications

Inhibitory effects of some drugs on carbonic anhydrase enzyme purified from Kangal Akkaraman sheep in Sivas, Turkey

Inhibitory effects of some drugs on carbonic anhydrase enzyme purified from Kangal Akkaraman sheep in Sivas, Turkey

Metamizole: A Review Profile of a Well-Known “Forgotten” Drug. Part II: Clinical Profile

Is there a Role for Gallium-67 Citrate SPECT/CT, in Patients with Renal Impairment or Who are Renal Transplant Recipients, in Identifying and Localizing Suspected Infection?

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