Risk factors for requiring cholecystectomy for gallstone disease in a prospective population-based cohort study

Talseth, Arne; Ness-Jensen, Eivind; Edna, Tom-Harald; Hveem, Kristian

doi:10.1002/bjs.10205

Cited by 12 publications

(12 citation statements)

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“…9 Similar findings were seen in the studies by Talseth, in Sweden, in 2016 and Stender in 2013 in which a causal association between elevated BMI and increased risk of symptomatic gallstone disease was seen. 14,15 But a study by Hui Sun et al in 2009 (China) stated that the causal association is gender specific and obese women are more significantly associated with gallstone disease compared to obese men. 13 In the present study, 56.52% patients had mixed diet as compared to 43.48% patients with vegetarian diet but this association was not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Cholelithiasis: causative factors, clinical manifestations and management

2019

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Background: Cholelithiasis is a common gastrointestinal disorder with an overall prevalence of 2-29%. This study aims to evaluate the evolution of demographic and etiological factors, the clinical manifestations of Cholelithiasis, the surgical management with its post-operative complications and the histopathological findings of the post-cholecystectomy specimen of gallbladder, in central India.Methods: Patients symptomatic or asymptomatic diagnosed ultrasonically as cholelithiasis were included in the study and patients with primary choledocholithiasis were excluded.Results: A total of 92 patients were enrolled, of which 62 (68.89%) were female, with mean age of 45.03yrs ± 13.59. Fifty four patients (58.69%) were having BMI >25. Pain was most common complaint seen in all patients. Jaundice was observed in 13 patients (14.13%) who had associated CBD calculus. Sickling was positive in 8.69% of patients. Lap cholecystectomy was done in 71 (77.17%) patients with a conversion rate of 6.57%. Nineteen (20.65%) were open cholecystectomy with or without CBD exploration and 2 underwent Lap cholecystostomy. Post operatively, surgical site infection was seen in 3 patients (4.22%) of laparoscopic cholecystectomy, 5 patients (26.31%) of open cholecystectomy and biliary leak was seen in 3 patients (15.78%) of open cholecystectomy. Histopathology of gallbladder was chronic cholecystitis in 70 patients (77.77%), malignancy was detected in 5 patients (5.55%) and Xanthogranulomatous cholecystitis in 2 patients (2.22%).Conclusions: Cholelithiasis is commonly seen in females in 4th and 5th decade mainly presenting with abdominal pain and dyspepsia. Laparoscopic cholecystectomy offers best surgical management with lesser complications.

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Section: Discussionmentioning

confidence: 99%

Cholelithiasis: causative factors, clinical manifestations and management

2019

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“…Vigorous aerobic exercise (measured by history of running distance) and cardiorespiratory fitness (an independent predictor of liver fat 141 ) are both inversely related to gallstone disease risk. 144 Also in women, vigorous exercise is associated with a decreased rate of cholecystectomy, 145 an additional potential risk factor for NAFLD. 143 Recreational physical activity is inversely related to risk of asymptomatic gallstones in adult women.…”

Section: Physical Activity and Gallbladder Diseasementioning

confidence: 99%

“…143 Recreational physical activity is inversely related to risk of asymptomatic gallstones in adult women. 144 Also in women, vigorous exercise is associated with a decreased rate of cholecystectomy, 145 an additional potential risk factor for NAFLD. 146 Of note, an increment of cardiorespiratory fitness by one MET reduces the odds of suffering from gallstone disease by 8% in men and 13% in women.…”

Section: Physical Activity and Gallbladder Diseasementioning

confidence: 99%

Exercising the hepatobiliary‐gut axis. The impact of physical activity performance

Molina-Molina

Baccetto

Wang

et al. 2018

Eur J Clin Investigation

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“…In the paediatric population this increase has been attributed to increases in BMI 3 . Population based studies have also identified an increased BMI as a risk factor for subsequent cholecystectomy 4 . As a result the number of procedures for gallstone disease has risen with cholecystectomy becoming the most common elective surgical procedure in the United States 1 .…”

Section: Introductionmentioning

confidence: 99%

Increases in cholecystectomy for gallstone related disease in South Africa

Khan

Brand

2020

Sci Rep

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Studies suggest that the rate gallstone disease in Africa is low. previous studies suggested an increase in gallstone rates and cholecystectomies related to urbanization and the adoption of Western lifestyle habits. this study examined cholecystectomy rates for gallstone disease in South Africa (SA). An audit of cholecystectomies in SA was done by reviewing gallbladder specimens processed by the SA National Health Laboratory Service (NHLS) from 2004 and 2014. Urbanization rates were obtained from Statistics South Africa and BMi data from previously published studies. fisher's exact test, t test's and pearson's R were used for comparisons; cholecystectomy rates were calculated per 100,000 population. 33,467 cholecystectomy specimens were analysed. There was a 92% absolute increase in cholecystectomies during the study period (Pearson r 0.94; p < 0.01) with the overall cholecystectomy rate increasing by 65% from 8.36 to 13.81 per 100,000 population. The data was divided into two equal periods and compared. During the second period there was a 28.8% increase in the number cholecystectomies and patients were significantly younger (46.9 vs 48.2 years; p ≤ 0.0001). The Northern Cape was the only province to show a decline in the cholecystectomy rate in this period and was also the only province to record a decline in urbanization. population based studies in SA demonstrate increases in BMi and an association with increased urbanization. this nationwide African study demonstrates a sustained increase in cholecystectomies for gallstone disease. increases in BMi and urbanization may be responsible for this trend. Gallbladder disease is a common and costly pathology. The development of gallstones varies among population groups around the world 1. In developed societies the rate of gallstone disease averages between 10 and 15%. The risk of developing symptomatic disease is approximately 2-3% per year and 10% five years after the development of stones 1. There is a causal association between changes in dietary intake, increases in body mass index (BMI) and symptomatic cholelithiasis 2. In the last thirty years the burden of disease has increased by more that 20% in the United States 1. In the paediatric population this increase has been attributed to increases in BMI 3. Population based studies have also identified an increased BMI as a risk factor for subsequent cholecystectomy 4. As a result the number of procedures for gallstone disease has risen with cholecystectomy becoming the most common elective surgical procedure in the United States 1. Two South African epidemiological studies completed during the 1980′s suggested that the rate of gallstone disease in the black "urban" African population was low 5,6. It was noted, however, that there was an increasing trend of patients with gallstone disease and the number of cholecystectomies being performed 5,6. An increasing exposure to a Western lifestyle was cited as the potential causal association. We hypothesized that the cholecystectomy rate for gallstone related disease h...

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Risk factors for requiring cholecystectomy for gallstone disease in a prospective population-based cohort study

Cited by 12 publications

References 22 publications

Cholelithiasis: causative factors, clinical manifestations and management

Cholelithiasis: causative factors, clinical manifestations and management

Exercising the hepatobiliary‐gut axis. The impact of physical activity performance

Increases in cholecystectomy for gallstone related disease in South Africa

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