Risk factors for relapse following treatment for first episode psychosis: A systematic review and meta-analysis of longitudinal studies

Álvarez‐Jiménez, Mario; Priede, Amador; Hetrick, Sarah; Bendall, Sarah; Killackey, Eóin; Parker, Alexandra G.; McGorry, Patrick D.; Gleeson, John

doi:10.1016/j.schres.2012.05.007

Cited by 393 publications

(296 citation statements)

References 56 publications

Supporting

Mentioning

266

Contrasting

Unclassified

Order By: Relevance

“…As in many previous studies (Coldham et al, 2002;Levy et al, 2012;Miller et al, 2011;Novak-Grubic and Tavcar, 2002;Verdoux et al, 2000), more than 40% of patients recruited showed poor adherence to their pharmacological treatment during the one year follow-up, but contrary to the published literature, this was not predicted by socio-demographic characteristics (Cotton et al, 2009;Perkins et al, 2008). Our findings are however in line with the previous literature (Alvarez-Jimenez et al, 2012) in showing an increased risk of non-remission due to poor medication adherence.…”

Section: Discussionsupporting

confidence: 86%

“…However, substance use during the year after psychosis onset significantly predicted poor medication adherence at follow-up. Lastly we clearly showed that substance use increases the risk of non-remission (Alvarez-Jimenez et al, 2012), with a more than 2-fold increased likelihood of not achieving remission for nicotine dependent and cannabis using patients. These findings are novel in demonstrating that this association is mediated by poor medication adherence, implying that medication adherence lies on the causal pathway between substance use and non-remission.…”

Section: Discussionmentioning

confidence: 73%

See 1 more Smart Citation

Substance use, medication adherence and outcome one year following a first episode of psychosis

Colizzi

Carra

Fraietta

et al. 2016

Schizophrenia Research

View full text Add to dashboard Cite

Substance use, medication adherence and outcome one year following a first episode of psychosis ABSTRACT Both substance use and poor medication adherence are associated with poor outcome in psychosis. To clarify the contributions of substance use and poor medication adherence to poor outcome in the year following a first episode of psychosis, 205 patients were evaluated for use of tobacco, alcohol, cannabis and stimulants at their psychosis onset, and in a 1-year follow-up. Data on medication adherence and symptom remission were also collected. Patients had high rates of overall substance use before (37-65%) and after psychosis onset (45-66%). 44% showed poor medication adherence and 55% did not reach remission from psychosis. Nicotine dependence and cannabis use after psychosis onset significantly predicted both poor medication adherence and nonremission, and poor medication adherence mediated the effects of these substances on nonremission. In conclusion, medication adherence lies on the causal pathway between nicotine dependence and cannabis on the one hand and non-remission on the other.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 73%

Substance use, medication adherence and outcome one year following a first episode of psychosis

Colizzi

Carra

Fraietta

et al. 2016

Schizophrenia Research

View full text Add to dashboard Cite

show abstract

“…However, relapse rates after initial response to acute pharmacological treatment are stubbornly high (Alvarez-Jimenez et al, 2012c) and clinically meaningful improvements in functional outcomes remain elusive (Alvarez-Jimenez et al, 2012b).…”

Section: Introductionmentioning

confidence: 99%

Online, social media and mobile technologies for psychosis treatment: A systematic review on novel user-led interventions

Álvarez‐Jiménez

Alcázar-Córcoles

González‐Blanch

et al. 2014

Schizophrenia Research

Self Cite

305

216

View full text Add to dashboard Cite

Esta es la versión de autor del artículo publicado en: This is an author produced version of a paper published in: Background: Internet and mobile-based interventions provide a unique opportunity to deliver cost-effective, accessible, time-unlimited support to people with psychosis. The aims of this study were to systematically compile and analyze the evidence on the acceptability, feasibility, safety and benefits of online and mobile-based interventions for psychosis. Methods: Systematic review of peer-reviewed studies examining the usability, acceptability, feasibility, safety or efficacy of user-led, Internet or mobile-based interventions, with at least 80% of participants diagnosed with schizophrenia-spectrum disorders. Results: Of 38 potentially relevant articles, 12 were eligible for inclusion. Interventions included web-based psycho-education; web-based psycho-education plus moderated forums for patients and supporters; integrated web-based therapy, social networking and peer and expert moderation; web-based CBT; personalized advice based on clinical monitoring; and text messaging interventions. Results showed that 74-86% of patients used the web-based interventions efficiently, 75-92% perceived them as positive and useful, and 70-86% completed or were engaged with the interventions over the follow-up. Preliminary evidence indicated that online and mobile-based interventions show promise in improving positive psychotic symptoms, hospital admissions, socialization, social connectedness, depression and medication adherence. Conclusions: Internet and mobile-based interventions for psychosis seem to be acceptable and feasible and have the potential to improve clinical and social outcomes. The heterogeneity, poor quality and early state of current research precludes any definite conclusions. Future research should investigate the efficacy of online and mobile interventions through controlled, well-powered studies, which investigate intervention and patient factors associated with take-up and intervention effects.

show abstract

“…2 The risk of recurrence is associated with symptoms, family support, insight and comorbidities. 3,4 As referred to in the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5), when individuals who are socially active withdraw from social activities, this is often the first sign of the disease. 5 Depending on the age at the onset of illness, individuals with schizophrenia may not be able to learn certain social skills.…”

Section: Introductionmentioning

confidence: 99%

Quality of life in schizophrenic patients: the influence of sociodemographic and clinical characteristics and satisfaction with social support

Pinho¹,

Pereira²,

Chaves³

2018

Trends Psychiatry Psychother.

View full text Add to dashboard Cite

Trends in Psychiatry and Psychotherapy Original ArticleResumo Objetivo: Avaliar a relação entre as características sociodemográficas e clínicas e a satisfação com o suporte social com a qualidade de vida dos doentes com esquizofrenia. Métodos: A amostra do estudo é de 268 participantes. Foi realizada uma entrevista para obter os dados sociodemográficos e clínicos e aplicados dois questionários para avaliar a qualidade de vida (World Health Organization Quality of Life instrumentAbbreviated version -WHOQOL-Bref) e a satisfação com o suporte social (Escala de Satisfação com o Suporte Social -ESSS). Foram efetuadas análises descritivas e inferenciais. Resultados: A maioria dos indivíduos era do gênero masculino (63,4%), com uma média de idade de 45,4 anos, solteiros (85,4%), vivendo com a família (62,3%) e desempregados (90,3%). Relativamente às características clínicas, 50,7% tinham a doença há menos de 20 anos, e 55,6% estiveram internados pelo menos uma vez nos últimos 5 anos. Os resultados demonstraram que estar empregado e não ter sido internado nos últimos 5 anos estão positivamente relacionados com um ou mais domínios da WHOQOL-Bref. A satisfação com a intimidade (p<0,001) e a satisfação com os amigos (p<0,001) foram independentemente associados ao escore total da WHOQOL-Bref. Conclusão: Ter emprego, não ter hospitalizações nos últimos 5 anos e estar satisfeito com o suporte social são fatores que influenciam positivamente a qualidade de vida dos doentes com esquizofrenia. Por conseguinte, é crucial que esses fatores sejam levados em conta nos programas de reabilitação com o suporte social, aumentando a rede de suporte, evitando recaídas e promovendo atividades ocupacionais. Descritores: Esquizofrenia, qualidade de vida, suporte social, dados demográficos. AbstractObjective: To evaluate the relationship of sociodemographic and clinical characteristics and satisfaction with social support with the quality of life of schizophrenic patients. Methodology: This study included a sample of 268 participants. An interview was conducted to obtain sociodemographic and clinical data, supplemented with two assessment tools used to evaluate quality of life (World Health Organization Quality of Life instrument-Abbreviated version -WHOQOL-Bref) and satisfaction with social support (Social Support Satisfaction Scale -SSSS). Descriptive and inferential analyses were performed. Results: Most individuals were male (63.4%), with a mean age of 45.4 years, single (85.4%), living with their family (62.3%) and unemployed (90.3%). As for clinical characteristics, most had the disease for less than 20 years (50.7%), and 55.6% had at least one hospitalization within the last 5 years. Being employed and having had no hospitalization within the last 5 years were positively correlated with one or more WHOQOL-Bref domains. The results of the variables intimacy (p<0.001) and satisfaction with friends (p<0.001) were independently related to the total WHOQOL-Bref score. Conclusion: Having a job, having had no hospitalization within the last 5...

show abstract

Risk factors for relapse following treatment for first episode psychosis: A systematic review and meta-analysis of longitudinal studies

Cited by 393 publications

References 56 publications

Substance use, medication adherence and outcome one year following a first episode of psychosis

Substance use, medication adherence and outcome one year following a first episode of psychosis

Online, social media and mobile technologies for psychosis treatment: A systematic review on novel user-led interventions

Quality of life in schizophrenic patients: the influence of sociodemographic and clinical characteristics and satisfaction with social support

Contact Info

Product

Resources

About