Risk factors for recurrent wheezing – International Study of Wheezing in Infants (EISL) phase 3

Aranda, Carolina Sánchez; Wandalsen, Gustavo Falbo; Fonzar, Ligia; Bianca, Ana Carolina Dela; Mallol, Javier; Solé, Dírceu

doi:10.1016/j.aller.2015.05.011

Cited by 11 publications

(3 citation statements)

References 28 publications

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“…Environmental exposure to allergens, irritants, and other specific factors leads to the development and maintenance of asthma symptoms. Different studies previously showed the association between viral infections, wheezing in infants, and exacerbation of asthma [4][5][6]. Infections with respiratory syncytial virus (RSV) and/or human rhinovirus (RV) are a fundamental cause in children's and adolescents' respiratory tract diseases and a major cause of bronchitis in children [1,7].…”

Section: Introductionmentioning

confidence: 99%

Identification and seasonality of rhinovirus and respiratory syncytial virus in asthmatic children in tropical climate

Lopes¹,

Amorim²,

Melo

et al. 2020

Bioscience Reports

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Introduction: Asthma is a disease that has been associated with the presence of different genetic and socioenvironmental factors. Objective: To identify and evaluate the seasonality of respiratory syncytial virus (RSV) and human rhinovirus (RV) in asthmatic children and adolescents in tropical climate, as well as to assess the socio-economic and environmental factors involved. Methods: The study was conducted in a referral hospital, where a total of 151 children were recruited with a respiratory infection. The ISAAC protocol and a questionnaire were applied, and a skin prick test was performed. The nasal swab was collected to detect RV and RSV through molecular assay. INMET database was the source of climatic information. Results: The of socio-environmental characterization of asthmatic children showed that the family history of allergy, disturbed sleep at night, dry cough, allergic rhinitis, individuals sensitized to at least one mite. We identified RV in 75% of children with asthma and 66.7% of RSV in children with asthma. There was an association between the presence of RV and the dry season whereas the presence of the RSV was associated with the rainy season. Contributing to these results, a negative correlation was observed between the RSV and the wind speed and the maximum temperature and a positive correlation with precipitation. Conclusions: The results suggest a high prevalence of RV and RSV in asthmatic children and the seasonality of these viruses were present in different climatic periods. This has significant implications for understanding short- and long-term clinical complications in asthmatic patients.

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Section: Introductionmentioning

confidence: 99%

Identification and seasonality of rhinovirus and respiratory syncytial virus in asthmatic children in tropical climate

Lopes¹,

Amorim²,

Melo

et al. 2020

Bioscience Reports

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“…In a previous study in Latin America, Mallol demonstrated that recurrent wheezing occurs in 1.6 out of 10 children, with a signi cant variation in severity and prevalence, with a high association with viral episodes (3). In a prospective study, Blanken (1) evaluated 3952 children and identi ed the frequency of day care and hospitalization for bronchiolitis as factors associated with recurrent wheezing.…”

Section: Discussionmentioning

confidence: 99%

Perinatal Predictors of Wheezing in the First Year of Life a Prospective Study in the South of Brazil

Veras

Lima

Pinto

et al. 2022

Preprint

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Introduction: Prematurity has been associated with the occurrence of respiratory symptoms throughout childhood, such as bronchiolitis and pneumonia. The identification of factors related to respiratory morbidity in childhood has direct implications for management and prevention. Objective: Evaluate the perinatal factors associated with wheezing in the first year of life in a prospective cohort of premature babies at a referral maternity hospital in southern Brazil.Methods: This is a prospective cohort of premature babies, less than 37 weeks of gestational age (defined by the Capurro Method or by ultrasound), and non-premature babies. The sample was non-probabilistic and defined by the ability to schedule follow-up appointments at the pulmonology outpatient clinic. The incidence rate for the occurrence of wheezing in the first year was estimated among full-term, premature, and extremely premature babies and adjusted for 1000 babies / year. Results: The number of newborns considered in the final analysis was 138 children (64 premature babies and 74 term babies). Regarding the general characteristics of the mothers, there was a predominance of low education (65.9%), of white ethnicity (79.7%), with an average age of 26 years. During the first year of life, 91 children (65.9%) visited the emergency room and 43 (31.2%) had at least one episode of wheezing. The occurrence of wheezing was 42.6% in male children (p = 0.010) 3). There was a higher percentage of wheezing episodes (35.9%) in preterm infants, especially those younger than 33 weeks (45%); however, this result was not statistically significant (p 0.260). In the multivariate analysis, only the male gender remained associated with the occurrence of wheezing in the first year of life (HR 2.24; 95% CI 1.19-4.21; p 0.012). Conclusions: In this follow-up study, the occurrence of wheezing in preterm infants in the first year of life was high, with twin pregnancy as the main risk factors, the male gender and the use of mechanical ventilation

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“…It has been recognized that in underdeveloped tropical regions, the wheezing prevalence can be similar or even higher than those reported in developed, industrialized regions ( 15 – 19 ). This predisposes the population to a high level of morbidity, especially in preschool children ( 20 ). In Colombia, the prevalence of asthma in the general population is 12%.…”

Section: Introductionmentioning

confidence: 99%

Risk Factors Associated With Health Care Utilization in Preschool Recurrent Wheezers in a Tropical Environment

Muñoz¹,

Guevara²,

Escamilla³

et al. 2021

Front. Allergy

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Introduction: The severity of wheezing episodes is related with the need for health services, but the factors associated with health care utilization in preschool recurrent wheezers in underdeveloped regions are unclear.Objective: To evaluate the factors associated with health care utilization in preschool recurrent wheezers in Cartagena, Colombia.Methods: One hundred twenty-seven recurrent wheezers (age 2–6 years old) who were admitted to the emergency room (ER) due to wheezing in a Pediatric reference hospital in Cartagena were included. Children were evaluated by means of questionnaires and classified according to the number of ER visits, need for hospitalization and history of intensive care unit (ICU) admission due to wheezing within the last year. Total serum IgE and specific IgE to house dust mite allergens (HDM) were measured by ImmunoCAP® and allergen sensitization was evaluated by skin prick tests (SPT).Results: The maternal report of nocturnal cough without fever in their children increased the risk to have ≥5 ER visits in the last year due to wheezing. The use of montelukast was negatively associated with hospitalization, while a history of pneumonia and lack of tap water, increased the risk of hospitalization due to wheezing. A history of bronchiolitis, family history of asthma, cohabiting with two or more siblings, passive exposure to smoke and lack of sewage facilities increased the risk of ICU admission due to wheezing. The presence of atopy evaluated by SPT reactivity, total IgE levels or specific IgE to HDM were not associated with health care utilization. We also found that seroprevalence of positive IgE (≥0.35 kU/L) was 27% to B. tropicalis and 20.3% to D. pteronyssinus but the prevalence of positive IgE sensitization to these allergens was below 2% and 8% when evaluated by SPT, respectively.Conclusions: Poverty indicators are associated with ICU admission in a group of preschool recurrent wheezers and should be considered as aggravating factors for wheezing. These factors must be systematically assessed in the medical approach in underdeveloped regions in the tropics. Nocturnal cough without fever is a symptom associated with frequent ER visits while atopy was not associated with health care utilization in preschool recurrent wheezers.

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Risk factors for recurrent wheezing – International Study of Wheezing in Infants (EISL) phase 3

Cited by 11 publications

References 28 publications

Identification and seasonality of rhinovirus and respiratory syncytial virus in asthmatic children in tropical climate

Identification and seasonality of rhinovirus and respiratory syncytial virus in asthmatic children in tropical climate

Perinatal Predictors of Wheezing in the First Year of Life a Prospective Study in the South of Brazil

Risk Factors Associated With Health Care Utilization in Preschool Recurrent Wheezers in a Tropical Environment

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