Risk factors for recurrent acute alcohol-associated pancreatitis: A prospective analysis

Abstract

Contrary to chronic pancreatitis, smoking was not found to be a risk factor for recurrent episodes after the first attack of acute alcoholic pancreatitis. Abstinence from alcohol protects against recurrent pancreatitis. Patients who developed recurrent acute pancreatitis had increased dependency on alcohol, demonstrated by the use of other sedatives in addition to alcohol and supported by the less decreased dependency during the follow-up.

Pancreatic Damage after the First Episode of Acute Alcoholic Pancreatitis and Its Association with the Later Recurrence Rate

“…This supports the current understanding that chronic inflammatory changes increase with time without further diagnosed attacks of AAP [23,24] . In contrast to observations in recurrent acute pancreatitis [4] , chronic changes without acute episodes developed without continuous alcohol consumption. This may also support the sentinel event hypothesis on the development of chronic pancreatitis [23,24] .…”

“…As most patients suffering a first episode of AAP have BMIs over 25 [4] , type II diabetes is possible with insulin resistance. In fact a frequent explanation for post-pancreatitis diabetes is overweight [17] .…”

“…These included oedema, atrophy, calcification, ductal changes (strictures of the main duct, reduced duct widening response to secretin) and pseudocysts. SMRP was performed as previously described [4] .…”

“…The annual absolute alcohol consumption has increased from 4.2 to 9.0 litres per inhabitant during the same time frame [1,2] . Approximately half of the patients who have suffered from an episode of acute alcoholic pancreatitis (AAP) will develop a recurrent attack [3] , continuous alcohol consumption being a risk factor for overall recurrence [4] and a first episode of mild acute pancreatitis being a risk factor for multiple recurrences [3] . After an episode of severe pancreatitis, the incidence of diabetes has been reported to be very high (up to 47-100%) when the pancreatitis had been treated with surgical debridement [5][6][7] .…”

Muutoksen polku alkoholin käytössä alkoholihaimatulehduksen jälkeen – yhdeksän vuoden seurantatutkimus

“…Vaikka tulehdus haimassa yleensä para nee, niin alkoholin käytön jatkuessa se voi myös kroonistua ja aiheuttaa haiman toiminnan häi riöitä. Alkoholin käytön lopettamista pidetään keskeisenä keinona ehkäistä uudelleen sairastu mista sekä haiman toiminnan häiriöitä ja siksi al koholihaimatulehdukseen sairastuneita ohjataan raittiuteen (24)(25). Tämä asettaa sairastuneen haasteelliseen tilanteeseen, kun hän joutuu koh taamaan uudelleen sairastumisen uhkan ja mah dollisen alkoholiriippuvuutensa.…”