Risk Factors for Recurrence after Keloid Surgery with Electron Radiotherapy

Liu, Chunlei

doi:10.21203/rs.3.rs-2688073/v1

Cited by 1 publication

(2 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, one study investigating factors influencing the recurrence rate after keloid surgery reported that age did not emerge as an independent risk factor. 61 Therefore, further research is essential to clarify age's impact on keloid activity. Additionally, differences in sampling procedures could have affected healing of the biopsy site.…”

Section: Discussionmentioning

confidence: 99%

“…Interpreting our results, considering three patients in their 50s to 60s, underscores the need for nuanced age consideration. However, one study investigating factors influencing the recurrence rate after keloid surgery reported that age did not emerge as an independent risk factor 61 . Therefore, further research is essential to clarify age's impact on keloid activity.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Revealing the pathogenesis of keloids based on the status: Active vs inactive

Oh,

Yeo,

Shim

et al. 2024

Experimental Dermatology

View full text Add to dashboard Cite

Recently, the pathomechanisms of keloids have been extensively researched using transcriptomic analysis, but most studies did not consider the activity of keloids. We aimed to profile the transcriptomics of keloids according to their clinical activity and location within the keloid lesion, compared with normal and mature scars. Tissue samples were collected (keloid based on its activity (active and inactive), mature scar from keloid patients and normal scar (NS) from non‐keloid patients). To reduce possible bias, all keloids assessed in this study had no treatment history and their location was limited to the upper chest or back. Multiomics assessment was performed by using single‐cell RNA sequencing and multiplex immunofluorescence. Increased mesenchymal fibroblasts (FBs) was the main feature in keloid patients. Noticeably, the proportion of pro‐inflammatory FBs was significantly increased in active keloids compared to inactive ones. To explore the nature of proinflammatory FBs, trajectory analysis was conducted and CCN family associated with mechanical stretch exhibited higher expression in active keloids. For vascular endothelial cells (VECs), the proportion of tip and immature cells increased in keloids compared to NS, especially at the periphery of active keloids. Also, keloid VECs highly expressed genes with characteristics of mesenchymal activation compared to NS, especially those from the active keloid center. Multiomics analysis demonstrated the distinct expression profile of active keloids. Clinically, these findings may provide the future appropriate directions for development of treatment modalities of keloids. Prevention of keloids could be possible by the suppression of mesenchymal activation between FBs and VECs and modulation of proinflammatory FBs may be the key to the control of active keloids.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%