Risk Factors for Radiological Progression Within Admissive One Week in the Hospitalized COVID-19 Omicron Variant-Infected Patients

Abstract

Purpose Recently, the SARS-CoV-2 Omicron variant was identified as responsible for a novel wave of COVID-19 worldwide. We perform a retrospective study to identify potential risk factors contributing to radiological progression in the COVID-19 patients due to the Omicron variant infection. These findings would provide guiding information for making clinical decisions that could improve the Omicron infection prognosis and reduce disease-related death. Methods This is a retrospective cohort study from a single center in China. According to the radiological change within admissive one week, enrolled cases were divided into two groups: the progressive (1w-PD) and the stable or improved disease (1w-non-PD). Separate analyses were performed on patients stratified into subgroups using the Mann–Whitney U -test, the Fisher exact test, or the Chi-squared test and a multivariable logistic regression analysis. Results Both the 1w-non-PD and 1w-PD cohorts displayed comparable asymptomatic infection, have similar underlying disease, impairment in respiratory function, coagulation dysfunction, tissue injury, SARS-CoV-2 viral load, and disease severity. However, the 1w-PD cohort was more inclined to cluster in populations presented with age between 41 and 65, higher CURB-65 scores, undetectable SARS-CoV-2 IgG, and lung affection. Based on the multiple logistic regression analysis, complicated bilateral and ground-glass opacities (GGOs) like pneumonia at admission were independent risk factors to radiological progression within admissive one week. Conclusion This study provided preliminary data regarding disease progression in Omicron-infected patients that indicated the development of pneumonia in the context of Omicron infection was worthy of potential risk factors.

Prognostic Factors and Outcomes in Advanced Stage Lung Cancer Patients with COVID-19 Omicron Variant Infection

“…Recent investigations have unveiled distinct patterns in the characteristics and outcomes of patients hospitalized with COVID-19 under the influence of the Omicron variant compared to prior viral variants, showcasing a notable decrease in disease severity and mortality rates. 2 , 3 Data indicate an exacerbation rate of up to 13.08% among Omicron-infected patients. Moreover, individuals who have cancer, coupled with multiple comorbidities including type 2 diabetes, obesity, and cardiovascular diseases that weakened immune systems, are predisposed to experiencing worse COVID-19 infections and outcomes.…”

“…1 In November 2021, a new variant of concern, Omicron, emerged within the SARS-CoV-2 lineage, presenting heightened transmissibility and the concerning potential for re-infecting individuals previously exposed to COVID-19. 2 The Omicron variant is notably highly contagious and has exhibited the capability to re-infect individuals who had recently recovered from COVID-19. 2 infections and outcomes.…”

“…2 The Omicron variant is notably highly contagious and has exhibited the capability to re-infect individuals who had recently recovered from COVID-19. 2 infections and outcomes. 4,5 Notably, individuals with lung cancer harbor an accumulation of risk factors contributing to COVID-19 morbidity and mortality, including advanced age, a multitude of comorbidities, a history of smoking, lung damage associated with the tumor, and the immunosuppressive effects of cancer treatments.…”

“…4,5 Notably, individuals with lung cancer harbor an accumulation of risk factors contributing to COVID-19 morbidity and mortality, including advanced age, a multitude of comorbidities, a history of smoking, lung damage associated with the tumor, and the immunosuppressive effects of cancer treatments. 2,6,7 Nevertheless, there remains a gap in understanding the precise clinical trajectory of COVID-19 Omicron variant infection, particularly concerning the relationships between patient outcomes, clinical laboratory parameters, and features indicative of interstitial lung disease on CT scans. 8 Consequently, it is of utmost importance to uncover predictive markers and risk factors that can empower clinicians to accurately identify life-threatening conditions in lung cancer patients afflicted with COVID-19 Omicron infection.…”

“… 2 The Omicron variant is notably highly contagious and has exhibited the capability to re-infect individuals who had recently recovered from COVID-19. 2 …”