Risk factors for QTc interval prolongation

Heemskerk, Charlotte P M; Pereboom, Marieke; Stralen, Karlijn J. van; Berger, F.; Bemt, Patricia M. L. A. van den; Kuijper, Aaf F.M.; Hoeven, R. T. M. van der; Mantel‐Teeuwisse, Aukje K.; Becker, Matthijs L.

doi:10.1007/s00228-017-2381-5

Cited by 70 publications

(62 citation statements)

References 23 publications

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“…46,47 Identifiable risk factors for QTc-interval prolongation include electrolyte abnormalities, cardiovascular disease, genetics, female sex, increasing age, and, most notably, certain medications. 48 Electrolyte abnormalities including hypokalemia, hypomagnesemia, and hypocalcemia were associated with significant elevations (more than 10 ms) in the QTc interval. The presence of one QTc-interval-prolonging medications such as a macrolide antibiotic was associated with an increase of roughly 10-15 ms, with additional medications contributing to a much smaller degree (~5 ms).…”

Section: Qtc-interval Prolongationmentioning

confidence: 99%

“…Identifiable risk factors for QTc‐interval prolongation include electrolyte abnormalities, cardiovascular disease, genetics, female sex, increasing age, and, most notably, certain medications . Electrolyte abnormalities including hypokalemia, hypomagnesemia, and hypocalcemia were associated with significant elevations (more than 10 ms) in the QTc interval.…”

Section: Qtc‐interval Prolongationmentioning

confidence: 99%

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Treatment of Helicobacter pylori in Special Patient Populations

et al. 2019

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Helicobacter pylori infection can lead to gastritis, gastric and duodenal ulcers, and gastric cancer. Consequently, complete eradication is the goal of therapy. First‐line therapy for H. pylori infection includes clarithromycin triple therapy (clarithromycin, proton pump inhibitor [PPI], and amoxicillin or metronidazole), bismuth quadruple therapy (bismuth salt, PPI, tetracycline, and metronidazole or amoxicillin), or concomitant therapy (clarithromycin, PPI, amoxicillin, and metronidazole). However, many patients have relative contraindications to the antibiotics included in these regimens, making therapy selection difficult. Furthermore, failure of initial therapy makes selection of second‐line therapy challenging due to concerns for potential resistance to agents included in the initial regimen. This review discusses H. pylori microbiology, including antibiotic resistance, and summarizes the existing evidence for first‐ and second‐line treatment regimens that may be considered for special populations such as patients with penicillin allergies, patients with or at risk for QTc‐interval prolongation, and patients who are pregnant, breastfeeding, or elderly.

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Section: Qtc-interval Prolongationmentioning

confidence: 99%

Section: Qtc‐interval Prolongationmentioning

confidence: 99%

Treatment of Helicobacter pylori in Special Patient Populations

et al. 2019

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“…15 years of age. 37 Since numerous risk factors for QTc interval prolongation have been described, [38][39][40][41] we accurately reviewed any concomitant pharmacological treatment associated with QTc prolongation.…”

Section: Qtc Evaluationmentioning

confidence: 99%

Hypocalcemia following Neridronate Administration in Pediatric Patients with Osteogenesis Imperfecta: A Prospective Observational Study

et al. 2020

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The use of intravenous bisphosphonates has been linked to hypocalcemia both in children and adults with osteogenesis imperfecta (OI). The aims of this study were: (1) to investigate the incidence of hypocalcemia in the first 48 hours (T48) after neridronate infusion in a pediatric population with OI and (2) to assess any correlation between the baseline values of calcium, vitamin D (25-hydroxyvitamin D) and bone turnover markers, and the postinfusion calcium values. We conducted a prospective observational study on 37 pediatric patients. All patients were treated with a single infusion of neridronate at a dose of 1 to 2 mg/kg. The study provided two postinfusion reassessments: 24 hours (T24) and T48 after neridronate administration. Hypocalcemia was observed in 11% of patients at T24 and in 50% of patients at T48 from neridronate infusion. We observed a positive linear correlation between the baseline vitamin D values and postinfusion calcium values, both at baseline and at T24 and T48. Hypocalcemia was mild and asymptomatic in all cases. Postinfusion calcium levels were related to baseline vitamin D levels. Consequently, low vitamin D levels should be considered a significant risk factor for hypocalcemia and should be carefully investigated and treated before neridronate infusion.

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“…As previously described [2], the QT increases with some risk factors, including electrolyte disturbances, female gender, cardiovascular diseases, genetic variants, and using certain drugs. However, the main factor is age.…”

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confidence: 70%

Comment on Lecca, L.I.; Portoghese, I.; Mucci, N.; Galletta, M.; Meloni, F.; Pilia, I.; Marcias, G.; Fabbri, D.; Fostinelli, J.; Lucchini, R.G.; Cocco, P.; Campagna, M. Association between Work-Related Stress and QT Prolongation in Male Workers. Int. J. Environ. Res. Public Health 2019, 16, 4781

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Hsieh

et al. 2020

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Lecca et al., in a recent publication in the Int. J. Environ. Res. Public Health had made some mistakes in the statistical analysis and interpretation of the results. Age was not a clear contributing factor in the prolongation of QT interval in the electrocardiogram (ECG), as there were strong confounders in their study. The effects of age were mainly faded out because of the age range of the participants. The use of Pearson’s correlation is questionable because of the normality assumptions was not met on the studied variables. They also made some conclusions about the effects of long and night shifts on the QT prolongation that were not appropriate based on their study type. All of these mentioned issues might completely change the validity of the conclusions they made.

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Risk factors for QTc interval prolongation

Abstract: We identified and quantified various risk factors for QTc interval prolongation.

Cited by 70 publications

References 23 publications

Treatment of Helicobacter pylori in Special Patient Populations

Treatment of Helicobacter pylori in Special Patient Populations

Hypocalcemia following Neridronate Administration in Pediatric Patients with Osteogenesis Imperfecta: A Prospective Observational Study

Comment on Lecca, L.I.; Portoghese, I.; Mucci, N.; Galletta, M.; Meloni, F.; Pilia, I.; Marcias, G.; Fabbri, D.; Fostinelli, J.; Lucchini, R.G.; Cocco, P.; Campagna, M. Association between Work-Related Stress and QT Prolongation in Male Workers. Int. J. Environ. Res. Public Health 2019, 16, 4781

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