Risk factors for pulmonary embolism in lung cancer patients with lower limb deep venous thrombosis: a case-control study

Dong, H.; Tong, Michael; Wang, Juan; Liu, Yuan; Tao, Guangyu; Petersen, René Horsleben; Jara-Palomares, Luis; Wang, Yi; Sun, Yan-Bing; Chen, Jie

doi:10.21037/tlcr-23-346

Cited by 3 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The conclusion that SHBG is causally associated with PE but not DVT requires further validation. The transition from DVT to PE involves intricate physiological regulation, and several risk factors which predict the occurrence of PE in DVT patients, such as hypertension, diabetes, long lying state, glucocorticoid therapy, and D-dimer levels, have been reported [ 36 , 37 ]. Therefore, our findings may allow us to speculate that SHBG could potentially be associated with a higher risk of PE development in DVT patients within the context of VTE formation.…”

Section: Discussionmentioning

confidence: 99%

Causal inference of sex hormone-binding globulin on venous thromboembolism: evidence from Mendelian randomisation

Wang,

Bai

et al. 2023

Thrombosis J

View full text Add to dashboard Cite

Background Previous cohort studies have shown that exogenous sex hormone use, such as testosterone replacement therapy and oestrogen-containing contraceptives, can increase the risk of venous thromboembolism (VTE). However, the relationship between endogenous sex hormone levels and VTE remains unclear. The goal of the present study was to explore the causal roles of endogenous sex hormones, including hormone-binding globulin (SHBG), bioactive testosterone (BT), and total testosterone (TT), in VTE and its two subgroups, deep vein thrombosis (DVT) and pulmonary embolism (PE). Methods We used a genome-wide association study of sex hormones as exposure data and Finnish VTE data as the outcome. Inverse variance weighting, MR-Egger, and weighted median were used for two-sample Mendelian randomisation (MR). Sensitivity analyses included MR-Egger, MR-PRESSO, Cochrane Q test, MR Steiger, leave-one-out analysis, and funnel plot, combined with multivariate MR and replicated MR analyses using larger VTE data from the global biobank meta-analysis initiative. Linkage disequilibrium score regression (LDSC) was used to determine genetic associations and estimate sample overlap. Results Our findings genetically predicted that an increase in serum SHBG levels by one standard deviation (SD) caused 25% higher odds for VTE (OR: 1.25, 95% CI: 1.01−1.55) and 58% higher odds for PE (OR: 1.58, 95% CI: 1.20−2.08). LDSC supported the genetic correlation between these two traits and replicated analyses confirm SHBG’s genetic effect on VTE in both sexes (OR: 1.46, 95% CI: 1.20−1.78) and in females (OR: 1.49, 95% CI: 1.17−1.91). In addition, an increase in serum TT levels by one SD caused 32% higher odds for VTE (OR: 1.32, 95% CI: 1.08−1.62) and 31% higher odds for DVT (OR: 1.31, 95% CI: 1.01−1.69); however, LDSC and replicated analyses did not find a genetic correlation between TT and VTE or its subtypes. No significant correlation was observed between BT and all three outcome traits. Conclusion Our study provides evidence that elevated serum SHBG levels, as predicted by genetics, increase VTE risk. However, the causal effect of testosterone levels on VTE requires further investigation.

show abstract

Section: Discussionmentioning

confidence: 99%

Causal inference of sex hormone-binding globulin on venous thromboembolism: evidence from Mendelian randomisation

Wang,

Bai

et al. 2023

Thrombosis J

View full text Add to dashboard Cite

show abstract

“…Під час аналізу порівняли дві групи пацієнтів. До Отже, результати цього дослідження свідчать, що розвиток ТЕЛА у хворих на рак має негативний вплив на прогноз, виразність якого залежить від послідовності розвитку подій, і хворі, в яких злоякісне захворювання було діагностовано після ТЕЛА, частіше мають поширений процес із метастазами та гірший прогноз [30].…”

Section: обговоренняunclassified

The course of the pulmonary embolism in patients with oncological diseases

Целуйко,

Шило,

Романенко

2024

CSIC

View full text Add to dashboard Cite

The aim – to identify factors associated with in-hospital mortality among patients with acute pulmonary embolism (PE) and oncological diseases. Materials and methods. A retrospective analysis of 647 medical records of patients with acute PE treated at one center from January 1, 2018, to January 1, 2020, was conducted. Among them, 115 patients had verified oncological diseases. PE diagnosis in all patients was confirmed by computed tomography and/or autopsy results. Alongside laboratory studies, patients underwent ultrasound examination. Results and discussion. A comparative assessment of clinical and anamnestic parameters in patients with PE, depending on the presence of oncological diseases, was conducted. The analysis revealed that patients with PE associated with oncological process were on average 5 years older, with higher proportion of elderly patients, and less frequently had anamnestic episodes of venous thrombosis (13.9 % vs. 24.6 %), but predictably more often had additional risk factors, such as blood transfusions, central venous catheters, and laparoscopic interventions. According to the results of the multifactorial regression analysis, factors independently influencing the risk of in-hospital death in patients with acute PE and oncological diseases included decrease of blood pressure, saturation, an increase of the pulmonary artery pressure, leukocytosis and presence of atrial fibrillation. The ROC analysis results allowed determining threshold values of parametric indicators associated with the risk of death during the hospital period in a patient with PE and oncological diseases, i.e. blood pressure ≤ 105 mm Hg, SpO2 ≤ 87 %, pulmonary artery pressure > 48 mm Hg, and leukocyte count > 9.8  109/l. Conclusion. The risk factors of in-hospital death in patients with PE associated with oncological disease are atrial fibrillation, increased pulmonary artery pressure, leukocyte count, low blood pressure and saturation.

show abstract

Risk factor analysis for early development of calf muscular vein thrombosis after thoracic surgery:a prospective observational study

Xu,

Miao,

She

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Venous thromboembolism is a common complication after thoracic surgery. The early development of calf muscular vein thrombosis (CMVT) after thoracic surgery is not well understood. The purpose of our study was to find the incidence and risk factors of early CMVT after thoracic surgery. Methods: We performed a prospective observational study in patients who received thoracic surgery from December 2021 to January 2023. The patients were assigned to either the CMVT or non-CMVT group based on their early postoperative lower extremity venous Doppler ultrasound results. The clinical characteristics of CMVT patients and non-CMVT patients would be compared and analyzed.Multivariate logistic regression analysis was conducted to identify independent risk factors associated with CMVT development. The area under the receiver operating characteristic curve was also calculated. Results: A total of 745 patients were included in the final analysis, with 185 (24.8%) and 560 (75.2%) patients in the CMVT and non-CMVT groups, respectively. In the CMVT group, 7 (3.8%) and 87 (47.1%) patients had concurrent proximal deep vein thrombosis and bilateral lower extremity thrombosis, respectively.Multivariate logistic regression analysis showed that age (OR = 1.092, 95% CI = 1.064–1.120, P = 0.000), Caprini score (moderate and high risks) (OR = 2.029, 95% CI = 1.276–3.227, P= 0.003), non-anticoagulation (OR = 1.859, 95% CI = 1.147–3.013, P = 0.012), operative duration >135 minutes (OR = 1.697, 95% CI = 1.135–2.538, P= 0.010), and postoperative day 1 D-dimer level (OR = 1.342, 95% CI = 1.232–1.462, P = 0.000) were independent risk factors for early postoperative CMVT. The receiver operating characteristic curve analysis showed that the areas under the curve for age and postoperative day 1 D-dimer were 0.715 (cut off value of 58.5) and 0.781 (cut off value of 1.445), respectively. Conclusions: The incidence of early CMVT after thoracic surgery was 24.8%. Nearly half of the CMVT patients had bilateral involvement. The risk of early CMVT was reduced after perioperative anticoagulation prophylaxis. In addition, older age, moderate and high Caprini risk score, operative time >135 minutes, and high postoperative day 1 D-dimer level were independent risk factors for the early development of CMVT after thoracic surgery.

show abstract

Risk factors for pulmonary embolism in lung cancer patients with lower limb deep venous thrombosis: a case-control study

Cited by 3 publications

References 29 publications

Causal inference of sex hormone-binding globulin on venous thromboembolism: evidence from Mendelian randomisation

Causal inference of sex hormone-binding globulin on venous thromboembolism: evidence from Mendelian randomisation

The course of the pulmonary embolism in patients with oncological diseases

Risk factor analysis for early development of calf muscular vein thrombosis after thoracic surgery:a prospective observational study

Contact Info

Product

Resources

About