Risk factors for progression of interstitial lung disease in Sjögren’s syndrome: a single-centered, retrospective study

He, Shi-Hao; He, Yayi; Guo, Kuang-Jin; Liang, Xu; Li, Shanshan; Li, Tian-Fang

doi:10.1007/s10067-021-05984-1

Cited by 18 publications

(22 citation statements)

References 36 publications

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“…What is more, CK‐MB is a specific indicator of myocardial injury and can be used to diagnose myocardial infarction without skeletal muscle injury. AST and LD not only reflect skeletal muscle lesions of the extremities but also have a high correlation with myocardial involvement and the occurrence of ILD 19,20 . Our results showed that the levels of CK, CK‐MB, and LD in the high ferritin SSc group were significantly higher than those in the normal ferritin SSc group.…”

Section: Discussionmentioning

confidence: 56%

“…AST and LD not only reflect skeletal muscle lesions of the extremities but also have a high correlation with myocardial involvement and the occurrence of ILD. 19 , 20 Our results showed that the levels of CK, CK‐MB, and LD in the high ferritin SSc group were significantly higher than those in the normal ferritin SSc group. This is consistent with the clinical manifestations of cardiac involvement in patients with high ferritin levels in our study.…”

Section: Discussionmentioning

confidence: 62%

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Clinical significance of serum ferritin in patients with systemic sclerosis

Jiang

Zhou

et al. 2022

Clinical Laboratory Analysis

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Objective The purpose of this study was to explore the clinical significance of serum ferritin (SF) in patients with systemic sclerosis (SSc). Methods The levels of SF were measured in 115 patients with SSc and 117 healthy controls (HCs). Clinical characteristics and laboratory indexes between the high ferritin SSc group and the normal ferritin SSc group were analyzed. Results The level of SF in SSc patients was significantly higher than that in HCs (319.78 [179, 554.33] ng/ml vs. 99 [49.03, 164.29] ng/ml, p < 0.01). Compared with the normal ferritin SSc group, the high ferritin SSc group was more likely to develop skin diffuse cutaneous SSc, fingertip arthralgia, and cardiac involvement. In addition, the levels of glutamine transaminase (GGT), alanine aminotransferase (ALT), creatine kinase (CK), creatine kinase isoenzyme‐MB (CK‐MB), lactate dehydrogenase (LD), immunoglobulin G (IgG), immunoglobulin A (IgA), C‐reactive protein (CRP), erythrocyte sedimentation rate (ESR), and the positive rate of anti‐Scl70 antibody in the high ferritin SSc group were significantly higher (each p < 0.05). SF was positively correlated with GGT, ALT, CK, CK‐MB, LD, IgA, CRP, and ESR (each p < 0.05). Multiple linear regression analysis showed that cardiac involvement, ALT, and ESR were independent influencing factors of SF in SSc. Conclusion Our study shows that the level of SF in patients with SSc is increased, and the elevated SF is related to abnormal liver function, myocardial involvement, inflammatory status, and production of autoantibodies in SSc. Cardiac involvement, ALT, and ESR are independent factors affecting SF in SSc.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 62%

Clinical significance of serum ferritin in patients with systemic sclerosis

Jiang

Zhou

et al. 2022

Clinical Laboratory Analysis

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“…Other authors detected higher levels of erythrocyte sedimentation rate, Creactive protein, fibrinogen, IgG, and C3 and lower levels of albumin in ILD-pSS patients compared with pSS patients without ILD (71). Clinical and serological features associated with the progression of ILD included male sex, non-sicca disease onset, and higher levels of baseline lactic dehydrogenase (LDH), as well as low baseline forced vital capacity (FVC) (72). Novel blood biomarkers are under study as predictors of the prognosis for pSS-ILD patients, including Krebs von den Lungen-6 (KL-6).…”

Section: Interstitial Lung Diseasementioning

confidence: 99%

“…Furthermore, He SH et al showed that pSS patients with progressive ILD were characterized by low baseline FVC, high baseline LDH, and more reticular pattern on chest HRCT, compared with stable ILD-pSS subjects. The antinuclear antibodies (ANA) spectrum was not different between these two groups (72). In contrast, the absence of honeycombing and higher levels of oxygen partial pressure (PaO2) were associated with increased survival (41), and sicca complaints at initial referral and preserved baseline FVC resulted in being protective from ILD progression (72).…”

Section: Interstitial Lung Diseasementioning

confidence: 99%

Chest high-resolution computed tomography in primary Sjögren's syndrome: an up-to-date primer for rheumatologists

Cereser

Giovannini

Caronia

et al. 2022

Clinical and Experimental Rheumatology

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Pulmonary manifestations, including airway involvement and interstitial lung disease, are the most frequent extra-glandular complications of primary Sjögren's syndrome (pSS). Chest high-resolution computed tomography (HRCT) is a cornerstone of pulmonary diagnostic imaging, aiming to detect, characterise, and quantify such conditions. In patients with pSS-related lung abnormalities, HRCT proved helpful in various clinical scenarios, including baseline and follow-up evaluation, assessment of superimposed infections, suspected progressive interstitial lung diseases, and acute exacerbation. This review aims to provide a primer for rheumatologists on chest HRCT, illustrating the up-to-date technique, imaging findings, and clinical indications in pSS and highlighting the importance of rheumatologist-radiologist constructive collaboration in the clinical management of such patients. Chest HRCT examination State-of-art techniqueRadiologists should perform chest HRCT according to updated recommendations to make the most of its potential, as highlighted in Table I (8,(19)(20)(21)(22)(23). Anatomo-radiologic correlationChest HRCT interpretation should rely on a basic understanding of pulmonary anatomy (19). In this regard, the sec-

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“…I read with great interest the article entitled "Risk factors for progression of interstitial lung disease in Sjögren's syndrome: a single-centered, retrospective study" by He et al [1]. The authors conducted a retrospective study to evaluate the risk in progression of interstitial lung disease (ILD) in 83 patients with primary Sjögren's syndrome (pSS), and a total of 32 patients (38.6%) underwent ILD progression.…”

mentioning

confidence: 99%