Risk factors for progression of visual field abnormalities in normal-tension glaucoma

Risk factors for progressive visual field loss in primary open angle glaucoma

“…Previous studies that failed to identify a relationship between IOP reduction and lower risk of visual field defect progression suggested that the relationship between IOP and progression might not be simple. 14 Rather than a linear relationship between visual field defect worsening and IOP control it is conceivable that individuals may have their own IOP damage thresholds with susceptibility to progressive damage determined by a variety of IOPindependent factors, perhaps including those identified in this study. Furthermore, it is also possible that our methodology, namely conservative choice of progression criterion or relatively short longitudinal review period, may have contributed to this negative finding.…”

“…This has resulted in increased knowledge of risk factors for development of glaucoma, [1][2][3][4][5][6][7][8] signs associated with glaucomatous optic nerve damage, characteristics of glaucomatous loss of visual function, [9][10][11][12][13] and consequently optimised decision-making strategies for discrimination between normal individuals and those with POAG. [14][15][16] Once an individual has been diagnosed with POAG, intraocular pressure-lowering treatment is commenced with the aim of preventing or decelerating progressive loss of visual function. Patients who receive treatment require lifelong follow-up to monitor the effectiveness of this intervention.…”

“…17 In clinical situations, the ability to identify individuals who have a higher likelihood of progressive glaucomatous damage is desirable to identify those patients who may require further treatment intervention. To date, a number of investigators have studied prognostic factors associated with progressive normal-tension glaucoma, 14,[18][19][20][21] but limited attempts have been made to identify risk factors for progressive POAG in treated patients. [22][23][24] The aim of this study was to evaluate routine ophthalmic data to identify clinically useful risk factors for progressive visual field loss in patients with POAG already receiving intraocular pressure-lowering treatments.…”

Evolution the Concepts of Role of Intraocular Pressure in Glaucoma Progression (Review)

“…Так, первая публикация потрясла мировое офтальмо-логическое сообщество: эффективность гипотензивной терапии нельзя считать доказанной [21]. Исследования продолжались, но при этом приводили к тому же вы-воду [22].…”

“…Наиболее важным фактором риска прогрессирования ГОН авторы Шведского исследования называют возраст, причем этот вывод совпадает с мнением других авторов [38,39,32,51]: с каждым годом жизни риск прогрессиро-вания возрастает на 1,04 условную единицу риска. Роль возраста в прогрессировании ГОН подчеркивается в ис-следовании AGIS в 2000 г., а также в Канадском глауком-ном исследовании [32].…”