Risk factors for primary liver carcinoma in Chinese population

Abstract

Abstract Abstract Abstract AIM: To evaluate the risk factors for primary liver carcinoma (PLC) in Chinese population. METHODS:Chinese Biomedical Literature Database, China Hospital Knowledge Database and MEDLINE were searched. All the related literatures were screened, and the risk factors for PLC in Chinese population were studied. Heterogeneity was evaluated by odds ratio (OR) q test. Combined OR and its 95% confidence interval (95%CI) were calculated, the association between the investigated risk factors and PLC was determined. Validity and bias of the findings were evaluated by sensitivity analysis and funnel plot analysis respectively. RESULTS:Fifty-five of one hundred and ninety identified studies were accepted according to the inclusive criteria. Ten factors related to PLC were demonstrated by sensitive analysis and funnel plot analysis. They were cirrhosis (OR = 11.97, P = 0.000), HBV infection (OR = 11.34, P = 0.000), HCV infection (OR = 4.28, P = 0.000), family history of liver cancer (OR = 3.49, P = 0.000), unstable emotion (OR = 2.20, P = 0.000), depressed characters (OR = 3.07, P = 0.000), aflatoxin (OR = 1.80, P = 0.000), alcoholic (OR = 1.88, P = 0.000), intake of musty food (OR = 1.87, P = 0.000) and drinking contaminated water from pond (OR = 1.77, P = 0.003). CONCLUSION:The main risk factors for PLC in China are liver diseases, family history of liver carcinoma, poor psychic status, aflatoxin, and some unhealthy behaviors.

Serological AFP/Golgi protein 73 could be a new diagnostic parameter of hepatic diseases

“…[24][25][26] Detection of GP73 in the serum of HCC, LC, hepatitis and healthy controls Sandwich ELISA was performed by the double antibodies (anti-GP73 mAb and pAb) conjugating the diluted samples (Fig. 1a).…”

A case-control study of the relationship between hepatitis B virus DNA level and risk of hepatocellular carcinoma in Qidong, China

“…Family history of liver carcinoma is one of the main risk factors for HCC, especially in the Chinese population [20][21][22] . In our study, 85/170 (50%) of cases had a family history of HBV-associated chronic liver diseases.…”

Association between MDM2-SNP309 and hepatocellularcarcinoma in Taiwanese population

“…The highest incidence rate of male HCC occurs in China and Taiwan, which is 58 and 53 per 100 000 men, respectively [2] . The main etiological agents that result in high incidence of HCC in the Asia-Pacific region include high infection rate with HBV and HCV, cirrhosis, family history, environmental contamination, diet, and α-fetoprotein [4,[24][25][26] . MDM2-SNP309 is a novel predictor for Japanese and Korean patients with HCC infected by HCV and HBV, respectively [20,21] .…”

“…Most newly diagnosed HCC is reported in Asia (> 70%), in which chronic HBV infection accounts for 75% of cases worldwide [3] . Significantly, 55% of HCC cases are reported from the Chinese population [4] . Although the incidence rate of HCC is plausibly linked to geographic area and geo-economic conditions, it is possible that gene polymorphism may be associated with the risk of HCC [5,6] .…”