Risk factors for preeclampsia in healthy nulliparous women: A prospective multicenter study

Sibai, Bahaeddine M; Gordon, Tavia; Thom, Elizabeth; Caritis, Steven N.; Klebanoff, Mark A.; McNellis, Donald; Paul, Richard H.

doi:10.1016/0002-9378(95)90586-3

Cited by 419 publications

(118 citation statements)

References 16 publications

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“…The odds ratio for initial diastolic blood pressure >75 mm Hg is almost twice higher than the odds ratio of 2.9 for first-trimester CD63 expression (Table III). This is in contrast with the study of Sibai et al 24 investigating clinical risk factors in healthy nulliparous women. Systolic blood pressure at 13 weeks appeared to be highly predictive and diastolic blood pressure was the least predictive.…”

Section: Commentcontrasting

confidence: 80%

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Can flow cytometric detection of platelet activation earlyin pregnancy predict the occurrence of preeclampsia?A prospective study

Konijnenberg¹,

Post²,

Mol³

et al. 1997

American Journal of Obstetrics and Gynecology

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Can flow cytometric detection of platelet activation early in pregnancy predict the occurence of preeclampsia ? A prospective study Konijnenberg, A.; van der Post, J.A.M.; Mol, B.W.J.; Schaap, M.C.L.; Lazarov, R.; Bleker, O.P.; Boer, K.; Sturk, A. Published in:American journal of obstetrics and gynecology DOI:10.1016/S0002-9378(97) Link to publication Citation for published version (APA): Konijnenberg, A., van der Post, J. A. M., Mol, B. W. J., Schaap, M. C. L., Lazarov, R., Bleker, O. P., ... Sturk, A. (1997). Can flow cytometric detection of platelet activation early in pregnancy predict the occurence of preeclampsia ? A prospective study. American journal of obstetrics and gynecology, 177, 434-442. https://doi.org/10.1016/S0002-9378(97)70212-6 General rightsIt is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. Amsterdam and Leiden, The NetherlandsOBJECTIVES: An increased platelet activation status is present in patients with preeclampsia. Our purpose was (1) to establish by means of flow cytometry whether platelets circulate in an activated state during the first and second trimesters of pregnancy and (2) to establish whether early platelet activation predicts the onset of preeclampsia. STUDY DESI6N: Consecutively, 244 pregnant women were included in a prospective study design. Platelets in whole blood samples from the pregnant women in the first trimester, the second trimester, and after delivery were labeled with the following antibodies associated with platetet activation: anti, CD62P (P-selectin, e-granule secretion), anti-CD63 (GP53, lysosomal secretion), anti-CD31 (GPIla', platelet endothelial cell adhesion molecule-I). The surface antigen exposure was determined by doublelabel flow cytometry with anti-CD42b (GPIb, a platelet-specific monoclonal glycoprotein) to select platelets and platelet-derived materials. Preeclampsia was defined as a diastolic blood pressure ->90 mm Hg and proteinuria ->0.3 gm in a 24-hour urine sample (International Society for Study of Hypertension in Pregnancy criteria). RESULTS: Seventeen of 244 patients had preeclampsia (6.9%). Only first-trimester CD63 expression had an area under the curve >0.5 by receiver-operator characteristic curve analysis and was selected as a possible predictor of preeclampsia. We found a sensitivity of 47% and a spec...

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Section: Commentcontrasting

confidence: 80%

“…First, this might he due to a different study group. In the article of Sibai et al 24 only healthy primigravid August 1997 AmJ Obstet Gynecol women were included. Second, we measured blood pressure with a standard sphygmomanometer.…”

Section: Commentmentioning

confidence: 99%

Can flow cytometric detection of platelet activation earlyin pregnancy predict the occurrence of preeclampsia?A prospective study

Konijnenberg¹,

Post²,

Mol³

et al. 1997

American Journal of Obstetrics and Gynecology

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“…In this study, we used blood pressure in the early mid-trimester of pregnancy as initial blood pressure to correlate with the incidence of PIH. Blood pressure values measured early in pregnancy or at the initial examination were recently reported to be related to the onset of PIH, 12,13) which is consistent with the findings of our present study. Odegård et al 14) reported that the relative risk of developing PE was 3.6 (95% CI, 2.0-6.6), showing a strong correlation with a systolic Our results also showed that severe preHT following hypertension plus proteinuria involves a higher risk of prolonged symptoms in the puerperal period.…”

Section: Discussionsupporting

confidence: 83%

Pre-hypertension predicts pregnancy induced hypertension and its postpartum progression

Makino

Iwata

Takeda

2013

Hypertens Res Pregnancy

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Aim:We investigated incidences of pregnancy induced hypertension (PIH) and prolonged symptoms (hypertension and/ or proteinuria) during the puerperal period, focusing on blood pressure in the early second trimester. Methods: Initial blood pressure data at 16 to 20 weeks of gestation were available from 1,398 women for analysis. Data were classified into the following groups: normal, mild pre-hypertension (preHT), severe preHT, and hypertension, according to JNC-7 criteria. Both the incidence and duration of symptoms were investigated in each group. Results: PIH incidences significantly increased as initial blood pressure increased. Also, significantly prolonged puerperal periods were observed in cases of severe preHT. Conclusions: Our data confirmed that initial blood pressure may be a useful predictor of subsequent PIH. Remaining symptoms in the puerperal period may be caused by latent endothelial cell dysfunction seen in preHT before or in early pregnancy.

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“…Primigravidae are 15 times more likely to develop protienuric PE than parous women, 21 which is similar to the present study where nulliparity almost triples the risk for PE. However, Sibai et al 22 showed that HDP are more frequent in multigravidae suggesting that multigravidae are more likely to have early-onset and severe disease.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for pre-eclampsia among women at antenatal booking in Kano, Northern Nigeria

Yakasai

Morhason-Bello

2013

Healthc Low Resour Settings

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Pre-eclampsia (PE) is an important cause of maternal mortality. There have been several studies on risk factors assessment with conflicting reports across the globe on this disease; however, rigorous recent evaluation of these factors is uncommon in this region. The aim of the present study was to determine the risks factors in the early-onset PE in Aminu Kano Teaching Hospital (AKTH), Kano (Northern Nigeria). We conducted a case-control study in Nigeria between April 2009 and January 2010 to identify the risk factors associated with the early-onset PE in women attending antenatal clinic in AKTH. Information on socio-cultural characteristics, medical history, previous obstetrics history, level of stress at home, and type of family were obtained and recorded in a proforma designed for the study. Multiple logistic regression analysis was used to determine the risk factors for PE at 95% confidence level. Pregnant women with early-onset PE (150 in each case and control group). Risk factors associated with increased risk of early-onset PE were: history of pre-eclampsia/eclampsia (PE/E) in a previous pregnancy [adjusted odds ratio (AOR) 2.09]; exposure to passive smoking (AOR 1.34); inadequate antenatal supervision (AOR 15.21); family history of hypertension in one or more 1 st -degree relative (AOR 8.92); living in a joint family (AOR 6.93); overweight (120% to 150% of pre-pregnancy ideal body weight, AOR 4.65). Risk factors among women in Northern Nigeria are similar to those reported from other studies. Good antenatal cares, early detection, reduction of stressful conditions at home are the most important preventive measures of early-onset severe PE among these women.

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Risk factors for preeclampsia in healthy nulliparous women: A prospective multicenter study

Cited by 419 publications

References 16 publications

Can flow cytometric detection of platelet activation earlyin pregnancy predict the occurrence of preeclampsia?A prospective study

Can flow cytometric detection of platelet activation earlyin pregnancy predict the occurrence of preeclampsia?A prospective study

Pre-hypertension predicts pregnancy induced hypertension and its postpartum progression

Risk factors for pre-eclampsia among women at antenatal booking in Kano, Northern Nigeria

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