Risk factors for post-operative complications after sentinel lymph node biopsy for cutaneous melanoma: Results from a large cohort study

Lindqvist, Ebba K.; Laine, Elisabeth; Kamali, Alexander; Sars, Carl; Gillgren, Peter; Schultz, Inkeri

doi:10.1016/j.bjps.2019.08.011

Cited by 10 publications

(14 citation statements)

References 22 publications

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“…Several post-operative complications are reported for SLNB with a frequency of about 10 % [15,16]. Seroma, wound infection, hematoma, lymphedema and nerve injury resulting in motor or sensory dysfunction have been described [15].…”

Section: Post-operative Follow-up Of 150 Patients With Sentinel Lymphmentioning

confidence: 99%

Post‐operative follow‐up of 150 patients with sentinel lymph node biopsy under tumescence local anesthesia

Eckardt

Häfner

Kofler

et al. 2021

J Deutsche Derma Gesell

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Background: Sentinel lymph node biopsy (SLNB) is useful for staging of patients with melanoma. Although SLNB is mostly performed under general anesthesia (GA), tumescence local anesthesia (TLA) can also be used. However, less data are available regarding feasibility of SLNB under TLA. Here we present a post-operative follow-up of 150 patients. Patients and Methods:We prospectively analyzed data from 150 patients with primary cutaneous malignant melanoma. We assessed pain, post-operative complications and patients' satisfaction after SLNB under TLA.Results: 32 % of the patients reported post-operative pain within the first 48 h after SLNB. Seroma was the most frequent complication, as 29 seromas after SLNB were observed. Wound infection was observed in 3.3 % of the patients. 98.7 % of the patients were satisfied with SLNB under TLA.Conclusions: SLNB under TLA is a safe and feasible option and should be considered for patients with melanoma. Especially with multimorbid or elderly patients, the risks of GA can be avoided.

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Section: Post-operative Follow-up Of 150 Patients With Sentinel Lymphmentioning

confidence: 99%

Post‐operative follow‐up of 150 patients with sentinel lymph node biopsy under tumescence local anesthesia

Eckardt

Häfner

Kofler

et al. 2021

J Deutsche Derma Gesell

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“…The 13.7% complication rate in our study is comparable to other papers with rates ranging from 9.5% to 25%; Moody et al . conducted a systematic review in 2016 identifying an average complication rate of 11.3% across 21 studies 17,27,32,40–42 . Consistently across all research, the most frequently observed complications after a SLNB were wound infection and seroma formation.…”

Section: Discussionmentioning

confidence: 86%

Proposed quality performance indicators of sentinel lymph node biopsy for cutaneous melanoma

Wen

Martin

2021

ANZ Journal of Surgery

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Background: Melanoma is a leading cause of morbidity and mortality in Australia and New Zealand. New Zealand has the highest melanoma incidence in the world alongside Australia at 54 per 100 000 persons. The aim of this study is to conduct a retrospective quality audit of sentinel lymph nodal biopsy (SLNB) practices from 2007 to 2019 of a high-volume melanoma surgeon. Primary outcome was false negative rate (FNR). Secondary outcomes were sentinel node (SN) identification and removal rate, and complication rates. Methods: A database was maintained, containing n = 553 consecutive SLNB's for cutaneous melanoma from 31 August 2007 to 31 August 2019. Patient characteristics and details of the primary lesion, sentinel lymph node biopsy, recurrence and complications were recorded. Results: SN's were successfully identified in 444 (99.6%) out of 446 patients with an FNR of 9.1%. Positive SN's were identified in 70 (12.7%) SLNB's. Complications occurred in 76 out of 553 (13.7%) SLNB's. A review of internationally published literature reveals an SN identification rate of 94.4-99.5% with an FNR of 4.0-37.5%. SLNB is the best staging tool for melanoma and gives potential access to adjuvant systemic treatment if >1 mm deposits are found. It is a day-stay procedure with a low-complication rate. Conclusion: SLNB is a safe and reliable procedure utilized for cutaneous melanoma. We propose our data should be used alongside international SN series to establish Quality Performance Indicators to improve melanoma management.

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“…Sentinel lymph node biopsy (SNB) is commonly employed in malignant melanoma and has previously routinely been followed by a completion lymph node dissection (CLND) with the purposes of achieving local cancer control and minimizing the risk of further spread. Surgical complications after SNB occur in approximately 12% of patients and include seroma, wound infection, lymphoedema, hematoma, and nerve injury [ 1 ]. These complications may also occur after CLND, and the overall complication rate is significantly higher after this procedure due to its extensive nature [ 2 ].…”

mentioning

confidence: 99%

“…Due to unspecified complications and/or inaccessible data, an additional 17 patients were excluded from further analysis. Details on post-operative complications after sentinel lymph node biopsy in our cohort have been published previously [ 1 ]. The most common complications were infection and seroma, followed by wound dehiscence, hematoma, lymphoedema, and other complication [ 1 ].…”

mentioning

confidence: 99%

“…Details on post-operative complications after sentinel lymph node biopsy in our cohort have been published previously [ 1 ]. The most common complications were infection and seroma, followed by wound dehiscence, hematoma, lymphoedema, and other complication [ 1 ]. The mean period between SNB and CLND was 45 days for patients with post-operative complications after SNB and 44 days for patients without post-operative complications ( p = 0.766).…”

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confidence: 99%

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Complications after surgery for malignant melanoma do not delay further treatment

et al. 2021

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Risk factors for post-operative complications after sentinel lymph node biopsy for cutaneous melanoma: Results from a large cohort study

Cited by 10 publications

References 22 publications

Post‐operative follow‐up of 150 patients with sentinel lymph node biopsy under tumescence local anesthesia

Post‐operative follow‐up of 150 patients with sentinel lymph node biopsy under tumescence local anesthesia

Proposed quality performance indicators of sentinel lymph node biopsy for cutaneous melanoma

Complications after surgery for malignant melanoma do not delay further treatment

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