Risk factors for poor tuberculosis treatment outcome in Finland: a cohort study

Vasankari, Tuula; Holmström, Pekka; Ollgren, Jukka; Liippo, K.; Kokki, M; Ruutu, Petri

doi:10.1186/1471-2458-7-291

Cited by 102 publications

(117 citation statements)

References 14 publications

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“…Male TB patients had lower treatment success rate than females. This in line with other reports that indicated women had higher probabilities of successful treatment outcome [20,21]. Our result also showed the absence of overall treatment success rate difference in Assosa and Pawe, though significantly high rates of not evaluated and lost to follow up were observed in Pawe and significantly high rate of death observed in Assosa.…”

Section: Discussionsupporting

confidence: 92%

Treatment Outcome of Tuberculosis Patients under Directly Observed Treatment of Short Course in Benishangul Gumuz Region, Western Ethiopia: A Ten-Year Retrospective Study

Disassa¹,

Teklu²,

Tafess³

et al. 2015

Gen Med (Los Angel)

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A retrospective study was conducted to assess TB treatment outcome and thus evaluate DOTS programme in Benishangul Gumuz Region, western Ethiopia. The records of 3658 TB patients registered in the two hospitals between November, 2003 and October, 2012 at DOTS Clinics were analyzed. From the total patients, 2,223 (60.77%) were successfully treated, 315 (8.61%) lost to follow up, 341 (9.32%) died, 4 (0.11%) failed treatment and 775 (21.19%) not evaluated. There is no association in treatment success rate between new and previously treated patients (60.55% vs. 58.33%, X 2 =0.14; P>0.704). When transferred out (not evaluated) is excluded, the success rate was increased approximately by a rate of 0.03 times while the time is increased by one year (β=0.03106; CI=0.0218-0.0403). Smear negative pulmonary TB patients had 1.24 times low treatment success rate (64.08% vs. 58.07%; CI=1.02-1.51; P<0.001) compared to smear positive. Patients from Pawe areas had 1.34 times lower treatment success rate compared to cases from Assosa (64.91% vs. 58.57%; CI=1.16-1.55). Not evaluated and lost to follow up rates were higher in Pawe (24.93% vs. 14.16%; X 2 =38.66; P<0.001 and 10.10% vs. 5.82%; X 2 =16.40; P<0.001 respectively) while death rate was higher in Assosa (14.95% vs. 6.33%; X 2 =59.05; P<0.001). Accordingly, males and elders had the trend to be more likely to experience death. In conclusion, the treatment success rate of TB patients was low which accounts for 60.77%. Low treatment success and high proportion of death (9.32%) and defaulted (8.61%) rates are serious public health concerns that point out low DOTs programme performance in the study areas.

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Section: Discussionsupporting

confidence: 92%

Treatment Outcome of Tuberculosis Patients under Directly Observed Treatment of Short Course in Benishangul Gumuz Region, Western Ethiopia: A Ten-Year Retrospective Study

Disassa¹,

Teklu²,

Tafess³

et al. 2015

Gen Med (Los Angel)

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“…According to data specific to Turkey, the highest rate of death was reported to be seen for the age group >65 (13.4%) (6), while a significant association between death and older age was consistently reported in several studies that may be partly explained by the effect of co-morbidity confounders (8)(9)(10)(11)(12)(13)(14)(15). Given that discontinuation of treatment has also been observed in a number of other conditions that require prolonged drug therapy, such as cardiovascular disease, rheumatic fever, leprosy, epilepsy, diabetes, and malaria prophylaxis, as well as the self-administration of oral contraceptives (16), co-morbidity was associated with a near doubling of the odds for an adverse treatment outcome in our study population.…”

Section: Discussionmentioning

confidence: 99%

A Retrospective Case-Control Study, Factors Affecting Treatment Outcomes for Pulmonary Tuberculosis in İstanbul, Turkey

Babalik¹,

Kılıçaslan²,

Kızıltaş³

et al. 2013

Balkan Med J

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“…Understanding the specific reasons for unsuccessful outcomes under the DOTS program is important in order to improve treatment strategy [7].…”

Section: Introductionmentioning

confidence: 99%

Outcome of Tuberculosis patients under directly observed short course treatment in western Ethiopia

Ejeta

Chala

Arega

et al. 2015

J Infect Dev Ctries

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Introduction: Treatment outcome is an important indicator of tuberculosis control programs, as suggested by the World Health Organization. However, this has not been well documented in the study area. This work contributes to a better understanding this issue. Methodology: A five-year (2009-2013) retrospective cohort study was conducted between April and May 2014, in six randomly selected health institutions providing tuberculosis treatment in western Ethiopia. Bivariate and multivariate logistic regression analyses were used to assess the association between treatment outcomes and predictor variables. Results: A total of 1,175 tuberculosis patients with a mean (standard deviation) age of 29.91 (13.99) were involved in the study. The majority of the study participants had smear-negative pulmonary tuberculosis (39.7%) and extrapulmonary tuberculosis (39.7%). Of all the study participants, 14.5% were cured, 56.3% completed treatment, 0.2% had treatment failure, 8.1% died during follow-up, 7.1% were reported as defaulters, and 13.8% were transferred out to another health institution. The overall treatment success rate was 70.8% and show progressive increases over the course of the study. The associated predictors were enrollment years, HIV co-infection, and sputum smear follow-up in the second, fifth, and seven months. Conclusions: The treatment success rate was unsatisfactory in spite of improvement seen over the study period. Thus, continued follow-up of patients, with frequent supportive supervision during the course of treatment, and provision of early detection and follow-up for HIV infection need to be strengthened to achieve an effective treatment outcome.

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Risk factors for poor tuberculosis treatment outcome in Finland: a cohort study

Abstract: Background: We investigated the patient-and treatment-system dependent factors affecting treatment outcome in a two-year cohort of all treated culture-verified pulmonary tuberculosis (TB) cases to establish a basis for improving outcomes.

Cited by 102 publications

References 14 publications

Treatment Outcome of Tuberculosis Patients under Directly Observed Treatment of Short Course in Benishangul Gumuz Region, Western Ethiopia: A Ten-Year Retrospective Study

Treatment Outcome of Tuberculosis Patients under Directly Observed Treatment of Short Course in Benishangul Gumuz Region, Western Ethiopia: A Ten-Year Retrospective Study

A Retrospective Case-Control Study, Factors Affecting Treatment Outcomes for Pulmonary Tuberculosis in İstanbul, Turkey

Outcome of Tuberculosis patients under directly observed short course treatment in western Ethiopia

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