Risk factors for polypharmacy in older adults in a primary care setting: a cross-sectional study

Ersoy, Süleyman; Engin, Velittin Selçuk

doi:10.2147/cia.s176329

Cited by 29 publications

(29 citation statements)

References 52 publications

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“…Actually, patients dealing with chronic pain demand and use more medication than healthy individuals, and it can be expected to find a significant association between these two issues. In a Turkish study with 1000 community dwelling older adults, Ersoy and Engin (48) found that chronic pain was an independent risk factor for daily drug consumption in older patients. In fact, our study group consists of solely individuals older than 80 years.…”

Section: Discussionmentioning

confidence: 99%

Chronic Pain and Related Factors in Patients Aged ≥80 Years

Özkök¹

2019

ejgg

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Objective: Chronic pain ranks among one of the most common, costly and incapacitating conditions in later life. The prevalence of chronic pain in the adult population ranges from 20% to 50%. Pain among older persons is almost always the result of pathology involving a physical or psychological process. In this study, we aimed to assess the prevalence of chronic pain in older adults and factors associated with chronic pain. Materials and Methods: A total of 215 patients aged ≥80 years were included in the study. In addition to the demographic characteristics of the patients, geriatric syndromes were assessed and comprehensive geriatric assessment of frailty and functional and nutritional status was performed to detect chronic pain prevalence and its associated factors in older adults. SPSS 21 for Windows program was used for statistical analysis. Results: Of the patients included in the study, 145 were female (67.4%) and 70 were male (32.6%). The mean age of the patients was 83.9±3.5 years. Chronic pain was present in 124 patients (57.7%) and was more common in females (p=0.006). When the relationship between chronic pain and geriatric syndromes was evaluated, falls in the past year, urinary incontinence, frailty and depressive mood were found to be associated with chronic pain (p=0.04, p=0.001, p=0.000 and p=0.04, respectively). Female gender and frailty were independently associated with chronic pain with odds ratios of 2.07 and 4.78, respectively. Conclusion: We found a high rate of chronic pain and geriatric syndromes as well as an association between them. To effectively address chronic pain in later life, a multimodal approach to treatment must involve a comprehensive assessment of pain in the older adult and management including pharmacologic and nonpharmacologic treatments that incorporate the functional, cognitive and comorbidity status of the patient.

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Section: Discussionmentioning

confidence: 99%

Chronic Pain and Related Factors in Patients Aged ≥80 Years

Özkök¹

2019

ejgg

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“…Multiple-drug prescriptions for the treatment of diseases and complications usually occurs in humans and animals [1,2]. One category of adverse drug reactions (ADRs) is de ned as drug-drug interactions (DDIs), in which one drug interferes with another.…”

Section: Introductionmentioning

confidence: 99%

Comparing potential drug-drug interactions in veterinary medications using two electronic databases

Boonyarattanasoonthorn

Khemawoot

Kijtawornrat

2020

Preprint

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Background: One of the most common global health issues in humans and animals is drug-drug interactions (DDIs). This issue increases the risks associated with healthcare in both human and veterinary medicine, as animals live long lives and receive many medicines to treat their illnesses. Currently, many electronic databases are being used as tools for potential DDI prediction, for example, Micromedex and Drugs.com. The purpose of this study was to examine the different abilities for the identification of potential DDIs in veterinary medicines by Micromedex and Drugs.com. Results: A list of 140 drugs, mainly used for the treatment of disease in animal hospitals, was complied, but the Micromedex and Drugs.com databases could recognise only 96 of these drugs. After inputting the recognised drug list into the databases, Micromedex showed 429 pairs of potential DDIs, whilst Drugs.com showed 842 pairs of potential DDIs. The analysis comparing results between the two databases showed 139 pairs (12.28%) with the same severity and 993 pairs (87.72%) with different severities. Major mechanisms of contraindicated and major potential DDIs were cytochrome P450 induction-inhibition and QT interval prolongation.Conclusion: Although Micromedex had a lower sensitivity to identify potential DDIs than Drugs.com, Micromedex provided more informative documentation. Veterinary pharmacists should evaluate potential DDIs from several databases and communicate with both the veterinarian and animal owner to ensure an appropriate drug prescription.

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“…Currently, the treatment of disease and complications are usually related to multiple drug use [1,2].…”

Section: Introductionmentioning

confidence: 99%

Comparing Potential Drug-Drug Interactions in Veterinary Medications Using Two Electronic Databases

Boonyarattanasoonthorn

Khemawoot

Kijtawornrat

2020

Preprint

View full text Add to dashboard Cite

Background: One of the most common global health issues in humans and animals is drug-drug interactions (DDIs). This issue increases the risks of health care in both human and veterinary medicine, as animals live long lives and receive many medicines to treat their illnesses. Currently, many electronic databases are using as a tool for potential DDI prediction, e.g., Micromedex and Drugs.com. The purpose of this study was to compare the ability of Micromedex and Drugs.com to detect potential DDIs in veterinary medicines.Results: There were 140 drugs, mainly used for the treatment of disease in animal hospitals, but the Micromedex and Drugs.com databases unidentified 44 items, therefore only 96 items were used in this study. The analysis detected 1,132 potential DDI pairs from the two databases. Micromedex identified 429 pairs of potential DDIs, while Drugs.com identified 842 pairs of potential DDIs. The same severity of the potential DDIs occurred between the two databases for 139 pairs (12.28%) and a different severity was found for 993 pairs (87.72%).Conclusion: Although Micromedex had a lower sensitivity to find out potential DDIs than Drugs.com, Micromedex provided more informative documentation. Veterinary pharmacists should evaluate potential DDIs from different databases and communicate with both the veterinarian and animal owners to ensure an appropriate drug prescription.

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Risk factors for polypharmacy in older adults in a primary care setting: a cross-sectional study

Cited by 29 publications

References 52 publications

Chronic Pain and Related Factors in Patients Aged ≥80 Years

Chronic Pain and Related Factors in Patients Aged ≥80 Years

Comparing potential drug-drug interactions in veterinary medications using two electronic databases

Comparing Potential Drug-Drug Interactions in Veterinary Medications Using Two Electronic Databases

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