Risk Factors for Physical Impairment after Acute Lung Injury in a National, Multicenter Study

Needham, Dale M.; Wozniak, Amy; Hough, Catherine L.; Morris, Peter E.; Dinglas, Victor D.; Jackson, James C.; Mendez-Tellez, Pedro A.; Shanholtz, Carl; Ely, E. Wesley; Colantuoni, Elizabeth; Hopkins, Ramona O.

doi:10.1164/rccm.201401-0158oc

Cited by 168 publications

(152 citation statements)

References 71 publications

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“…Secondary analyses were performed using data from two US-based studies (ARDSNet Long Term Outcomes Study [ALTOS] and Improving Care of Acute Lung Injury Patients [ICAP]) 11,12 and two Australianbased studies. 13,14 Patients from these studies with at least one 6MWD assessment in the 12 months aft er critical illness were included.…”

Section: Methodsmentioning

confidence: 99%

Construct Validity and Minimal Important Difference of 6-Minute Walk Distance in Survivors of Acute Respiratory Failure

Chan

Pfoh

Denehy

et al. 2015

Chest

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OBJECTIVE: Th e 6-min walk distance (6MWD), a widely used test of functional capacity, has limited evidence of construct validity among patients surviving acute respiratory failure (ARF) and ARDS. The objective of this study was to examine construct validity and responsiveness and estimate minimal important diff erence (MID) for the 6MWD in patients surviving ARF/ARDS . METHODS:For this secondary data analysis of four international studies of adult patients surviving ARF/ARDS (N 5 641), convergent and discriminant validity, known group validity, predictive validity, and responsiveness were assessed. MID was examined using anchor-and distribution-based approaches. Analyses were performed within studies and at various time points aft er hospital discharge to examine generalizability of fi ndings. RESULTS:Th e 6MWD demonstrated good convergent and discriminant validity, with moderate to strong correlations with physical health measures (| r | 5 0.36-0.76) and weaker correlations with mental health measures (| r | 5 0.03-0.45). Known-groups validity was demonstrated by diff erences in 6MWD between groups with diff ering muscle strength and pulmonary function (all P , .01). Patients reporting improved function walked farther, supporting responsiveness. 6MWD also predicted multiple outcomes, including future mortality, hospitalization, and health-related quality of life. Th e 6MWD MID, a small but consistent patient-perceivable effect, was 20 to 30 m. Findings were similar for 6MWD % predicted, with an MID of 3% to 5%. CONCLUSIONS:In patients surviving ARF/ARDS, the 6MWD is a valid and responsive measure of functional capacity. Th e MID will facilitate planning and interpretation of future group comparison studies in this population.

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Section: Methodsmentioning

confidence: 99%

Construct Validity and Minimal Important Difference of 6-Minute Walk Distance in Survivors of Acute Respiratory Failure

Chan

Pfoh

Denehy

et al. 2015

Chest

Self Cite

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“…[17][18][19] Conditions strongly associated with the development of ICU-acquired weakness include prolonged mechanical ventilation (> 7 days), sepsis, multisystem organ failure, as well as prolonged duration of the bed-restore deep sedation. [20][21][22] …”

Section: Incidence and Risk Factors Of Different Components Of Picsmentioning

confidence: 99%

Post-intensive care syndrome: An overview

Rawal

Yadav

Kumar

2017

Journal of Translational Internal Medicine

456

330

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Survival of critically unwell patients has improved in the last decade due to advances in critical care medicine. Some of these survivors develop cognitive, psychiatric and /or physical disability after treatment in intensive care unit (ICU), which is now recognized as post intensive care syndrome (PICS). Given the limited awareness about PICS in the medical faculty this aspect is often overlooked which may lead to reduced quality of life and cause a lot of suffering of these patients and their families. Efforts should be directed towards preventing PICS by minimizing sedation and early mobilization during ICU.All critical care survivors should be evaluated for PICS and those having signs and symptoms of it should be managed by a multidisciplinary team which includes critical care physician, neuro-psychiatrist, physiotherapist and respiratory therapist,with the use of pharmacological and non-apharmacological interventions. This can be achieved through an organizational change and improvement, knowing the high rate of incidence of PICS and its adverse effects on the survivor's life and daily activities and its effect on the survivor's family.

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“…The pathogenesis of ALI is complex and has remained to be fully elucidated (4). When ALI occurs, inflammatory cells, including neutrophils and macrophages, adhere, accumulate and can be activated in the lung (5). Afterwards, inflammatory cells produce large amounts of active oxygen and oxidase through respiratory burstand degranulation.…”

Section: Introductionmentioning

confidence: 99%

Salvianolic acid B attenuates lipopolysaccharide-induced acute lung injury in rats through inhibition of apoptosis, oxidative stress and inflammation

Zhao

Liu

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. The present study was performed to assess the protective effect of salvianolic acid B on lipopolysaccharide (LPS)-induced acute lung injury (ALI). Sprague Dawley rats were injected with 100 µg/kg LPS through a 24-gauge catheter. One group of rats was pre-treated with salvianolic acid B (1 mg/ml; 20 ml/kg body weight) 1 h prior to LPS challenge, then 20 ml/kg salvianolic acid B every 2 days for 4 weeks thereafter. Salvianolic acid B attenuated LPS-induced increases in the lung wet/dry weight rate and lung tissue injury in ALI model rats. LPS-induced changes in the content of caspase-3, malondialdehyde, superoxide dismutase, catalase, glutathione peroxidase, tumor necrosis factor-α and interleukin-6 in ALI model rats were attenuated by treatment with salvianolic acid B. Furthermore, treatment with salvianolic acid B inhibited the protein expression of type I collagen I, endogenous transforming growth factor-β1 production and α-smooth muscle actin in ALI model rats. These findings indicated that salvianolic acid B attenuates LPS-induced ALI through inhibition of apoptosis, oxidative stress and inflammation in rats and therefore exertsa protective effect against ALI.

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Risk Factors for Physical Impairment after Acute Lung Injury in a National, Multicenter Study

Cited by 168 publications

References 71 publications

Construct Validity and Minimal Important Difference of 6-Minute Walk Distance in Survivors of Acute Respiratory Failure

Construct Validity and Minimal Important Difference of 6-Minute Walk Distance in Survivors of Acute Respiratory Failure

Post-intensive care syndrome: An overview

Salvianolic acid B attenuates lipopolysaccharide-induced acute lung injury in rats through inhibition of apoptosis, oxidative stress and inflammation

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