Risk Factors for Pancreatic Neuroendocrine Tumors

Halfdanarson, Thorvardur R.; Bamlet, William R.; McWilliams, Robert R.; Hobday, Timothy J.; Burch, Patrick A.; Rabe, Kari G.; Petersen, Gloria M.

doi:10.1097/mpa.0000000000000234

Cited by 59 publications

(72 citation statements)

References 19 publications

(25 reference statements)

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“…These results were supported by two independent studies from Capurso et al 15. and Halfdanarson et al 17. Similarly, our data provided strong evidence of an association between diabetes and the risk of NF-PNET, with an AOR of 1.96 (95% CI, 1.14–3.70).…”

Section: Discussionsupporting

confidence: 89%

“…but was in contrast to the other reports1517. We believe this inconsistency could be attributed to the limited size of the study sample, the different inclusion criteria for cases, and the different methods of quantification of alcohol consumption.…”

Section: Discussioncontrasting

confidence: 62%

“…With respect to the association between diabetes and PNETs risk, several studies141517 including two meta-analyses1225 have consistently indicated diabetes as a potential risk factor for development of PNETs. Hassan et al .…”

Section: Discussionmentioning

confidence: 99%

“…In addition, our study excluded all patients with an inherited syndrome (MEN-1 and VHL). One earlier study was conducted on cases diagnosed as either F-PNETs or NF-PNETs15, and two other studies did not describe the biological behavior of the tumors1417. The mechanisms linking diabetes to PNETs development remain unknown.…”

Section: Discussionmentioning

confidence: 99%

“…Many epidemiological studies have evaluated risk factors for pancreatic adenocarcinomas91011; however, little is known about the possible role of environmental risk factors for sporadic PNETs12. Several potential risk factors have been postulated for PNETs, which include social economic factors, family history of cancer (FHC), smoking habits, alcohol consumption, body mass index (BMI) and type 2 diabetes1314151617. All of these studies have a case-control design and have been conducted in the USA131417, Europe15 and China16.…”

mentioning

confidence: 99%

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Risk Factors for Sporadic Pancreatic Neuroendocrine Tumors: A Case-Control Study

Ben

Zhong

Fei

et al. 2016

Sci Rep

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The current study examined risk factors for sporadic pancreatic neuroendocrine tumors (PNETs), including smoking, alcohol use, first-degree family history of any cancer (FHC), and diabetes in the Han Chinese ethnic group. In this clinic-based case-control analysis on 385 patients with sporadic PNETs and 614 age- and sex-matched controls, we interviewed subjects using a specific questionnaire on demographics and potential risk factors. An unconditional multivariable logistic regression analysis was used to estimate adjusted odds ratios (AORs). No significant differences were found between patients and controls in terms of demographic variables. Most of the patients with PNETs had well-differentiated PNETs (G1, 62.9%) and non-advanced European Neuroendocrine Tumor Society (ENETS) stage (stage I or II, 83.9%). Ever/heavy smoking, a history of diabetes and a first-degree FHC were independent risk factors for non-functional PNETs. Only heavy drinking was found to be an independent risk factor for functional PNETs (AOR = 1.87; 95% confidence interval [CI], 1.01–3.51). Ever/heavy smoking was also associated with advanced ENETS staging (stage III or IV) at the time of diagnosis. This study identified first-degree FHC, ever/heavy smoking, and diabetes as risk factors for non-functional PNETs, while heavy drinking as a risk factor for functional PNETs.

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Section: Discussionsupporting

confidence: 89%

Section: Discussioncontrasting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Risk Factors for Sporadic Pancreatic Neuroendocrine Tumors: A Case-Control Study

Ben

Zhong

Fei

et al. 2016

Sci Rep

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The incidence and survival of pancreatic cancer by histology, including rare subtypes: a nation‐wide cancer registry‐based study from Taiwan

et al. 2018

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Studies have indicated a significant rise in the incidence of pancreatic adenocarcinoma. However, the epidemiology of other rare histologic subtypes of pancreatic cancer is not well understood. This study analyzed the incidence and survival of pancreatic cancer in Taiwan by histologic subtype, sex, age group, and year of diagnosis. The incidence trends of pancreatic cancer in Taiwan from 2002 to 2013 were calculated using data from the Taiwan Cancer Registry. The survival of pancreatic cancer patients was assessed using the life‐table method and Cox proportional hazards analysis. The incidence of pancreatic cancer increased from 4.62 per 100,000 in 2002 to 6.04 per 100,000 in 2013 in Taiwan. The most common histologic subtype of pancreatic cancer was adenocarcinoma followed by carcinoma and neuroendocrine tumors (NETs). Adenocarcinoma and NETs showed a rapid increase in incidence, while the incidences of other subtypes did not change significantly. Patients with adenocarcinoma showed a poor survival with a 5‐year survival of 5.2%. Patients with endocrinomas, NETs, and lymphoma displayed a better survival than those with adenocarcinoma, with a 5‐year survival ranging from 41.8% to 59.1%. The survival of adenocarcinoma, lymphoma, and NETs improved after the introduction of novel therapies. Understanding the risk factors and identifying the biomarkers for the early diagnosis of pancreatic cancer are important to prevent the development and improve the survival of pancreatic cancer.

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Pancreaticoduodenectomy and metastasectomy for metastatic pancreatic neuroendocrine tumors

Chawla

Williams

Sich

et al. 2018

Journal of Surgical Oncology

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Risk Factors for Pancreatic Neuroendocrine Tumors

Cited by 59 publications

References 19 publications

Risk Factors for Sporadic Pancreatic Neuroendocrine Tumors: A Case-Control Study

Risk Factors for Sporadic Pancreatic Neuroendocrine Tumors: A Case-Control Study

The incidence and survival of pancreatic cancer by histology, including rare subtypes: a nation‐wide cancer registry‐based study from Taiwan

Pancreaticoduodenectomy and metastasectomy for metastatic pancreatic neuroendocrine tumors

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