Risk Factors for Osteoporosis in Crohnʼs Disease

Azzopardi, Neville; Ellul, Pierre

doi:10.1097/mib.0b013e31828075a7

Cited by 31 publications

(9 citation statements)

References 53 publications

(58 reference statements)

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“…The third main finding in our study is that low BMI was a risk factor for reduced BMD, which matches data from previous studies[ 17 , 29 , 30 ]. This finding was more evident in CD patients than in UC patients; BMI could predict the severity of reduced BMD with a sensitivity of 77% and a specificity of 63%, AUC 0.73 (95%CI: 0.59–0.84) in the CD group.…”

Section: Discussionsupporting

confidence: 92%

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Updated bone mineral density status in Saudi patients with inflammatory bowel disease

Ewid

Mutiri

Omar

et al. 2020

WJG

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BACKGROUND Little is known about inflammatory bowel disease (IBD) burden and its impact on bone mineral density (BMD) among adult patients in Saudi Arabia. To the best of our knowledge, our study is the only study to give an update about this health problem in adult Saudi patients with IBD. IBD is a great risk factor for reduced BMD due to its associated chronic inflammation, malabsorption, weight loss and medication side effects. Consequently, screening for reduced BMD among patients with IBD is of utmost importance to curb and control anticipated morbidity and mortality among those patients. AIM To assess the relationship between IBD and BMD in a sample of adult Saudi patients with IBD. METHODS Ninety adult patients with IBD - 62 Crohn’s disease (CD) and 28 ulcerative colitis (UC) - were recruited from King Fahad Specialist Hospital gastroenterology clinics in Buraidah, Al-Qassim. All enrolled patients were interviewed for their demographic information and for IBD- and BMD-related clinical data. All patients had the necessary laboratory markers and dual-energy x-ray absorptiometry scans to evaluate their BMD status. Patients were divided into two groups (CD and UC) to explore their clinical characteristics and possible risk factors for reduced BMD. RESULTS The CD group was significantly more prone to osteopenia and osteoporosis compared to the UC group; 44% of the CD patients had normal BMD, 19% had osteopenia, and 37% had osteoporosis, while 78% of the UC patients had normal BMD, 7% had osteopenia, and 25% had osteoporosis ( P value < 0.05). In the CD group, the lowest t -score showed a statistically significant correlation with body mass index (BMI) ( r = 0.45, P < 0.001), lumbar z -score ( r = 0.77, P < 0.05) and femur z -score ( r = 0.85, P < 0.05). In the UC group, the lowest t -score showed only statistically significant correlation with the lumbar z -score ( r = 0.82, P < 0.05) and femur z -score ( r = 0.80, P < 0.05). The ROC-curve showed that low BMI could predict the lowest t -score in the CD group with the best cut-off value at ≤ 23.43 (m/kg 2 ); area under the curve was 0.73 (95%CI: 0.59–0.84), with a sensitivity of 77%, and a specificity of 63%. CONCLUSION Saudi patients with IBD still have an increased risk of reduced BMD, more in CD patients. Low BMI is a significant risk factor for reduced BMD in CD patients.

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Section: Discussionsupporting

confidence: 92%

“…For our study, this result may be due to the lack of a registry to precisely record our patients’ steroid therapy details. Intake of prednisolone > 7.5 mg/d for 3 mo is an established risk for developing osteoporosis[ 33 ], as shown in previous studies[ 17 , 27 , 30 ].…”

Section: Discussionmentioning

confidence: 89%

Updated bone mineral density status in Saudi patients with inflammatory bowel disease

Ewid

Mutiri

Omar

et al. 2020

WJG

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“… 32 Multiple studies have also demonstrated an increased risk of serious infection, opportunistic infection, osteoporosis, morbidity, and mortality associated with steroid use in IBD. 6 , 33 , 34 Therefore, the older patients likely represent the most at-risk IBD subgroup for steroid-associated complications; however, maintenance steroid therapy seems to be more commonly prescribed over the steroid-sparing immunomodulators and biologics.…”

Section: Discussionmentioning

confidence: 99%

Older Age and Steroid Use Are Associated with Increasing Polypharmacy and Potential Medication Interactions Among Patients with Inflammatory Bowel Disease

Parian

2015

Inflammatory Bowel Diseases

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“…Smoking,8 obesity,9 chronic renal failure,10 hyperthyroidism,11 rheumatoid arthritis,12 inflammatory bowel diseases13 are well known to be associated with osteoporosis and have been reported on extensively. Obesity as a protective factor has already been reported 14.…”

Section: Discussionmentioning

confidence: 99%

Are cataracts associated with osteoporosis?

Nemet¹,

Hanhart²,

Kaiserman³

et al. 2013

OPTH

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BackgroundCalcium is considered an important factor in the development of both osteoporosis and cataract. This study evaluated the association between osteoporosis and cataracts.ObjectiveTo evaluate the prevalence of osteoporosis among patients undergoing cataract surgery, and the association between the two.Patients and methodsThis was a retrospective observational case-control study, conducted in the Central District of Clalit Health Services (a district of the largest health maintenance organization in Israel). All Clalit members in the district older than 50 years who underwent cataract surgery from 2000 to 2007 (n=12,984) and 25,968 age- and sex-matched controls comprised the sample. Electronic medical records of all patients in the study were reviewed. The main outcome measure was the prevalence of osteoporosis and the odds ratio of having osteoporosis among cataract patients compared with controls.ResultsDemographically, 41.8% were men with a mean age of 68.7 ± 8.2 years. A logistic regression model for osteoporosis showed that age, female sex, higher socioeconomic class, smoking, chronic renal failure, hyperthyroidism, rheumatoid arthritis, inflammatory bowel diseases, and cataract are all associated with increased prevalence of osteoporosis. Obesity is a protective factor for osteoporosis. In all age-groups, osteoporosis was more prevalent in cataract patients than in the control group.ConclusionAmong other well-known risk factors, osteoporosis is associated with the presence of cataracts. Common pathophysiological associations with both conditions, such as calcium imbalance, hormonal abnormalities, and shared genetic predisposition, are discussed.

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Risk Factors for Osteoporosis in Crohnʼs Disease

Cited by 31 publications

References 53 publications

Updated bone mineral density status in Saudi patients with inflammatory bowel disease

Updated bone mineral density status in Saudi patients with inflammatory bowel disease

Older Age and Steroid Use Are Associated with Increasing Polypharmacy and Potential Medication Interactions Among Patients with Inflammatory Bowel Disease

Are cataracts associated with osteoporosis?

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