Risk Factors for Osteoporosis in Patients With Rheumatoid Arthritis (Preliminary Results According to the Materials of the Multicenter Program «osteoporosis in Rheumatoid Arthritis: Diagnosis, Risk Factors, Fractures, Treatment»)

Таскина, Е. А.; Алексеева, Л. И.; Дыдыкина, И. С.; Podvorotova, Marina; Dydykina, Polina; Петрова, Е В; Раскина, Т. А.; Muradyants, A A; Zhugrova, E S; Peshekhonov, D. V.; Сизиков, А. Э.; Sorotskaya, V.; Bolshakova, T Yu; Виноградова, И. Б.; Dyomin, N. V.; Смирнов, А. В.; Насонов, Е. Л.

doi:10.14412/1995-4484-2014-393-397

Cited by 7 publications

(2 citation statements)

References 16 publications

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“…В то же время существует предположение, что применение низких доз ГК может оказывать антиостеопоротический эффект, снижать риск переломов вследствие подавления воспаления, уменьшения боли, увеличения двигательной активности пациентов [12][13][14].…”

Section: Changes Of Clinical and Radiographic Parameters During Denosunclassified

Changes of Clinical and Radiographic Parameters During Denosumab Therapy in Rheumatoid Arthritis Patients Receiving Glucocorticoids: Preliminary Results

Dydykina¹,

Петрова²,

Дыдыкина³

et al. 2015

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Section: Changes Of Clinical and Radiographic Parameters During Denosunclassified

Changes of Clinical and Radiographic Parameters During Denosumab Therapy in Rheumatoid Arthritis Patients Receiving Glucocorticoids: Preliminary Results

Dydykina¹,

Петрова²,

Дыдыкина³

et al. 2015

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“…По данным зарубежных авторов, частота ОП при РА варьировала от 4 до 55% [4,5]. В российском многоцентровом исследовании, проведенном в рамках программы «Остеопороз при ревматоидном артрите: диагностика, факторы риска, переломы, лечение», частота ОП у женщин с РА достигала 59% [6]. Такой широкий разброс данных объясняется различиями в методологии исследований, числе и этнической принадлежности обследованных пациентов, гетерогенностью самого заболевания, а также использованием разных вариантов терапии РА.…”

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Comparative evaluation of denosumab efficacy of in patients with rheumatoid arthritis and postmenopausal osteoporosis: results of 1-year study in clinical practice

Добровольская¹,

Коваленко²,

Торопцова³

et al. 2019

Naučno-praktičeskaâ revmatologiâ

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Objective: to assess bone mineral density (BMD) changes in rheumatoid arthritis (RA) patients with osteoporosis (OP) and in women with postmenopausal OP during therapy with denosumab (DSB) for 1 yearSubjects and methods. 121 women were included: the main group – 69 patients with RA (mean age – 60±7 years), 34 (49.3%) from them received glucocorticoids (GC). Comparison group comprised 52 women with primary OP (mean age – 62±10 years). Measurement of BMD using dual-energy X-ray absorptiometry (DXA) was performed in the lumbar spine (LI–IV), femoral neck (FN), proximal femur as a whole (PF) and distal forearm (DF). DSB was administered subcutaneously at a dose of 60 mg 1 time in 6 months.Results and discussion. In patients with RA, the average increase of BMD for 12 months of treatment was: in LI–IV – 4.6%, in FN-2.8%, in PF-3.0% and in DF-0.7%, and in the comparison group – 5.2; 2.1; 2.9 and 0.9%, respectively. There were no significant differences of BMD changes between the groups. Efficacy of DSB therapy in RA patients with OP did not depend on RA activity, duration of GC therapy and cumulative dose of GC. Adverse events that did not lead to the withdrawal of the drug were noted in 3% of the study participants. There were no fractures during the observation.Conclusion. The efficacy treatment with DSB for 1 year in RA patients with OP and in women with postmenopausal OP is comparable. The use of GC did not have a negative impact on DSB effect.

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Osteoporosis and sarcopenia in women with rheumatoid arthritis

Добровольская¹,

Феклистов²,

Efremova³

et al. 2020

Sovremennaâ revmatologiâ

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Objective: to assess bone mineral density (BMD) and the incidence of osteoporosis (OP) and sarcopenia (SP) in women suffering from rheumatoid arthritis (RA).Patients and methods. Eighty-one women (mean age, 59.0±8.1 years) with a reliable diagnosis of RA were examined. The women underwent the following studies: a survey using a special questionnaire; tests to measure the functional status of muscles, including those to determine their strength; as well as dual-energy X-ray absorptiometry of the axial skeleton and whole body.Results and discussion. According to the EWGSOP2 criteria, 20 (24.7%) female patients were diagnosed with SP, 24 (29.6%) had OP, and 39 (48.2%) had osteopenia. OP in female patients with and without SP occurred in 35.0 and 27.9% of cases, respectively (p>0.05). BMD in the femoral neck and in the proximal femur as a whole was significantly lower in the presence of SP than in its absence (p=0.0006 and p=0.0061, respectively). The frequency of falls was significantly higher in the female patients with SP than in those without SP (p=0.028). The major osteoporotic and hip fracture probabilities calculated according to the FRAX ® algorithm was higher in the patients with SP than in those without SP (p=0.041 and p=0.033, respectively). There were positive correlations of BMD with body mass index, appendicular muscle mass, appendicular muscle index, hand strength, shoulder circumference, and the serum levels of calcium, creatinine and uric acid, as well as negative correlations with age, postmenopausal length, and RA duration.Conclusion. OP and SP are common RA complications that increase the risk of falls and fractures.

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Risk Factors for Osteoporosis in Patients With Rheumatoid Arthritis (Preliminary Results According to the Materials of the Multicenter Program «osteoporosis in Rheumatoid Arthritis: Diagnosis, Risk Factors, Fractures, Treatment»)

Cited by 7 publications

References 16 publications

Changes of Clinical and Radiographic Parameters During Denosumab Therapy in Rheumatoid Arthritis Patients Receiving Glucocorticoids: Preliminary Results

Changes of Clinical and Radiographic Parameters During Denosumab Therapy in Rheumatoid Arthritis Patients Receiving Glucocorticoids: Preliminary Results

Comparative evaluation of denosumab efficacy of in patients with rheumatoid arthritis and postmenopausal osteoporosis: results of 1-year study in clinical practice

Osteoporosis and sarcopenia in women with rheumatoid arthritis

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