Risk Factors for Ossification of Posterior Longitudinal Ligament

Umesawa, Mitsumasa; Uchiyama, Köji; Taneichi, Hiroshi; Kobashi, Gén

doi:10.1007/978-981-13-1096-6_2

Cited by 1 publication

(1 citation statement)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The gene encoding BMP2 is located in 20p12.3 and consists of 12,561 bp. Patients with the rs1555785715 (G > T) allele in the BMP2 gene are more predisposed to OPLL than the control group [ 38 , 39 ]. However, Wang et al reported that the rs1555785715 SNP showed no significant difference between the OPLL and non-OPLL groups in the Chinese population [ 8 ].…”

Section: Resultsmentioning

confidence: 99%

Molecular and Genetic Mechanisms of Spinal Stenosis Formation: Systematic Review

Byvaltsev

Калинин

Hernandez

et al. 2022

IJMS

View full text Add to dashboard Cite

Spinal stenosis (SS) is a multifactorial polyetiological condition characterized by the narrowing of the spinal canal. This condition is a common source of pain among people over 50 years old. We perform a systematic review of molecular and genetic mechanisms that cause SS. The five main mechanisms of SS were found to be ossification of the posterior longitudinal ligament (OPLL), hypertrophy and ossification of the ligamentum flavum (HLF/OLF), facet joint (FJ) osteoarthritis, herniation of the intervertebral disc (IVD), and achondroplasia. FJ osteoarthritis, OPLL, and HLF/OLFLF/OLF have all been associated with an over-abundance of transforming growth factor beta and genes related to this phenomenon. OPLL has also been associated with increased bone morphogenetic protein 2. FJ osteoarthritis is additionally associated with Wnt/β-catenin signaling and genes. IVD herniation is associated with collagen type I alpha 1 and 2 gene mutations and subsequent protein dysregulation. Finally, achondroplasia is associated with fibroblast growth factor receptor 3 gene mutations and fibroblast growth factor signaling. Although most publications lack data on a direct relationship between the mutation and SS formation, it is clear that genetics has a direct impact on the formation of any pathology, including SS. Further studies are necessary to understand the genetic and molecular changes associated with SS.

show abstract

Section: Resultsmentioning

confidence: 99%