Risk factors for nosocomial infections in critically ill newborns: A 5-year prospective cohort study

Kawagoe, Julia Yaeko; Segre, Conceição Aparecida de Mattos; Pereira, Crèsio Romeu; Cardoso, M.F.S.; Silva, Claudia V.; Fukushima, Júlia Tizue

doi:10.1067/mic.2001.114162

Cited by 100 publications

(98 citation statements)

References 17 publications

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“…This distribution is similar to that reported by other authors [1,5,15,16], although different from some Brazilian reports [2,14], which describe pneumonia as the most common neonatal NI. The proportion of bloodstream infections in this study (68.2%) is definitely worrisome, since neonatal sepsis carries on a particular increased mortality, prolonged length of hospital stay and slower growth among very low birth weight infants and our rates are higher than those usually observed [1,3,5,15].…”

Section: Discussionsupporting

confidence: 76%

“…In this series, the overall NI incidence rate observed (34%) is approximately the mean of the recently reported Brazilian incidence rates (18.9% [2], 50.7% [14] and 22% [1]). …”

Section: Discussionsupporting

confidence: 50%

“…Especially in NICUs, NI is recognized as one of the most significant causes of morbidity and mortality among hospitalized newborns [2]. However, the exact impact of this condition is difficult to point out, since there is a wide variation in infection rates reported in the literature, possibly due to differences in surveillance or study methods.…”

Section: Discussionmentioning

confidence: 90%

“…Maternal infection has already been described as an independent risk factor for neonatal NI [2]. Abruptio placentae is a serious condition with a high mortality rate; liveborn infants frequently have neonatal complications, including birth asphyxia and the hazards of prematurity, what rises the need for medical intervention.…”

Section: Discussionmentioning

confidence: 99%

“…NIs still occur at an incidence of around 30% [1,2] and, in developing countries, are estimated to cause 40% of all neonatal deaths [3].…”

mentioning

confidence: 99%

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Risk factors for nosocomial infection in a Brazilian neonatal intensive care unit

et al. 2008

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This study was designed to describe the epidemiology and risk factors for nosocomial infection (NI) in a Brazilian neonatal intensive care unit (NICU). This study was a retrospective cohort from January to December, 2003. All neonates admitted to the NICU. Infection surveillance was conducted according to the NNIS, CDC. Chi-square test and logistic regression model were performed for statistical analyses. The study was conducted at a public, tertiary referral NICU of a teaching hospital in the Northeast of Brazil. A total of 948 medical records were reviewed. Overall NI incidence rate was 34%. The main neonatal NI was bloodstream infection (68.1%), with clinical sepsis accounting for 47.2%, and pneumonia was the second most common NI (8.6%). Multivariate analysis identified seven independent risk factors for NIs: birth weight, exposure to parenteral nutrition, percutaneous catheter, central venous catheter or mechanical ventilation, abruptio placentae and mother's sexually transmitted disease (STD). Neonates from mothers with STD or abruptio placentae, those weighing less than 1,500 g at birth or those who used invasive devices were at increased risk for acquiring NI.

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Section: Discussionsupporting

confidence: 76%

“…In this series, the overall NI incidence rate observed (34%) is approximately the mean of the recently reported Brazilian incidence rates (18.9% [2], 50.7% [14] and 22% [1]). …”

Section: Discussionsupporting

confidence: 50%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

“…NIs still occur at an incidence of around 30% [1,2] and, in developing countries, are estimated to cause 40% of all neonatal deaths [3].…”

mentioning

confidence: 99%

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