Risk factors for nosocomial imipenem-resistant Acinetobacter baumannii infections

Abstract

Our results suggest that the nosocomial occurrence of IRAB is strongly related to an ICU stay and duration of hospital stay, and that IRAB occurrence may be favored by the selection pressure of previously used antibiotics.

An Evaluation of Antibiotic Profile, Molecular Characterisation and Risk Factors Associated with Carbapenem Resistant Non Fermentative Gram Negative Isolates in a Tertiary Care Centre

“…Most of these IRAB isolates were from ICU-surgery followed by ICU-medicine and surgery ward. This is similar to the finding by Baran et al, (2008) who found IRAB more in ICUs than in wards and Khajuria et al, (2014) who reported that among his imipenem resistant isolates most isolates were from ICU-surgery.…”

“…The same observation was seen in case of P.aeruginosa in which also most of the first line antibiotics were resistant over 90% except for polymixin B, colistin, and aztreonam. Onguru et al, (2008) reported the presence of more than 70% resistance to most antibiotics in IRPA. Amudhan et al, and Behera et al, found that 91.8% and 87.5% of their imipenem resistant P. aeruginosa isolates were polymixin B sensitive.…”

“…Onguru et al, (2008) reported that longer duration of hospital stay was associated with infection with IRPA.…”

Recent Advances in the Immunopathogenesis of Acinetobacter baumannii Infection

“…ventilation during intensive care (5). Patients first become infected following colonization from the environment.…”

“…Sources of contamination include surgical equipment, endotracheal or nasogastric tubes, catheters and previously colonized health care staff. The length of stay at the ICU has repeatedly been associated with increased risk of colonization and infection (5)(6)(7). Colonization is usually asymptomatic but will increase the likelihood of subsequent infection, which may proceed when the host natural barriers are weakened by trauma, surgery or other invasive procedures.…”