Risk factors for nosocomial candidaemia: a case-control study in children

Paganini, Hugo; Brieshcke, T. Rodriguez; Santos, Paula Suene Pereira dos; Seu, Sandra; Rosanova, María Teresa

doi:10.1053/jhin.2002.1169

Cited by 36 publications

(33 citation statements)

References 21 publications

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“…12,14,15 There are also other studies reporting lower incidence rates. 16,17 Comparisons are problematic because nosocomial Candida infection rates may differ between different centers, reflecting variations in demographic and clinical characteristics of patient populations, principles of antibiotics practices, implementation of infection control precautions, and blood culture methods.…”

Section: Discussionmentioning

confidence: 99%

Epidemiologic and microbiologic evaluation of nosocomial infections associated with Candida spp in children: A multicenter study from Istanbul, Turkey

Sütçü

Salman

Aktürk

et al. 2016

American Journal of Infection Control

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Section: Discussionmentioning

confidence: 99%

Epidemiologic and microbiologic evaluation of nosocomial infections associated with Candida spp in children: A multicenter study from Istanbul, Turkey

Sütçü

Salman

Aktürk

et al. 2016

American Journal of Infection Control

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“…[15][16][17][18][19][20][21] Some of the well recognized risk factors include presence of central venous catheters, other invasive interventions and severity of primary illness (high PRISM Score). In developing countries like India the situation is compounded by the presence of severe malnutrition which is responsible for considerable immunosuppression.…”

Section: Risk Factors and Pathogenesismentioning

confidence: 99%

Invasive candidiasis in pediatric intensive care units

Singhi

Deep

2009

Indian J Pediatr

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Candidemia and disseminated candidiasis are major causes of morbidity and mortality in hospitalized patients especially in the intensive care units (ICU). The incidence of invasive candidasis is on a steady rise because of increasing use of multiple antibiotics and invasive procedures carried out in the ICUs. Worldwide there is a shifting trend from C. albicans towards non albicans species, with an associated increase in mortality and antifungal resistance. In the ICU a predisposed host in one who is on broad spectrum antibiotics, parenteral nutrition, and central venous catheters. There are no pathognomonic signs or symptoms. The clinical clues are: unexplained fever or signs of severe sepsis or septic shock while on antibiotics, multiple, non-tender, nodular erythematous cutaneous lesions. The spectrum of infection with candida species range from superficial candidiasis of the skin and mucosa to more serious life threatening infections. Treatment of candidiasis involves removal of the most likely source of infection and drug therapy to speed up the clearance of infection. Amphotericin B remains the initial drug of first choice in hemodynamically unstable critically ill children in the wake of increasing resistance to azoles. Evaluation of newer antifungal agents and precise role of prophylactic therapy in ICU patients is needed.

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“…Although anti-fungal drugs are administered at the start of chemotherapy this prophylaxis is often ineffective (14,20). In addition, the use of wide spectrum antibiotics, treatment with corticosteroids and cytostatic substances, and invasive surgical procedures often predispose children to the development of fungal infections (11,16).…”

Section: Introductionmentioning

confidence: 99%

Candidiasis in pediatric patients with cancer interned in a university hospital

Parahym¹,

Melo²,

Morais³

et al. 2009

Braz. J. Microbiol.

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Fungi are common causes of infection in immunocompromised patients. Candida species are frequently involved in these cases. In order to investigate candidiasis in pediatric patients with cancer, clinical samples were collected from one hundred and twenty two patients interned in the Oswaldo Cruz University Hospital in Recife, Brazil. Yeasts were isolated from thirty-four clinical samples. The species isolated were: Candida albicans (fourteen isolates), C. parapsilosis (nine isolates), C. guilliermondii (two isolates) and C. tropicalis (two isolates). We found that candidemia was most frequent in patients with malignant hematology and that C. parapsilosis infections caused the highest mortality.

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Risk factors for nosocomial candidaemia: a case-control study in children

Cited by 36 publications

References 21 publications

Epidemiologic and microbiologic evaluation of nosocomial infections associated with Candida spp in children: A multicenter study from Istanbul, Turkey

Epidemiologic and microbiologic evaluation of nosocomial infections associated with Candida spp in children: A multicenter study from Istanbul, Turkey

Invasive candidiasis in pediatric intensive care units

Candidiasis in pediatric patients with cancer interned in a university hospital

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