Risk factors for non‐adherence to medication in inflammatory bowel disease patients

D’Incà, R.; Bertomoro, P.; Mazzocco, Ketti; Vettorato, Maria Grazia; Rumiati, Rino; Sturniolo, G.C.

doi:10.1111/j.1365-2036.2007.03555.x

Cited by 121 publications

(111 citation statements)

References 38 publications

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“…Similarly, in the study of Shale and Riley [21] , in addition to being young, having education beyond the age of 16 years and being in full-time employment, being prescribed a 3-times-a-day regimen was identified as predictor for non-adherence. The need to take medicine during working hours (P = 0.001, OR: 3.5, 95% CI: 2.27-5.26), and multiple daily doses (P = 0.045, OR: 2.8, 95% CI: 0.99-7.70) were significantly associated with non-adherence in adults [22] , which was also confirmed by other studies [20,21] . Similarly, adolescents whose regimen involved more than one daily medication administration had more adherence barriers [26] .…”

Section: Drug Type and Dosing Regimessupporting

confidence: 78%

“…In contrast, other studies reported low adherence rates after long-term remission [3,22] . Very high non-adherence rates (74.3%) were reported for azathioprine in CD patients who were in long-term (> 48 mo) clinical remission [20] .…”

Section: Age and Disease Durationmentioning

confidence: 43%

“…In a recent Italian study [22] non-adherence was 43% in patients < 40 years old compared to 34% in those older than 40 years (P = 0.041, OR: 1.5, CI: 1.01-2.13). Recently, diagnosis and disease duration shorter than 5 years was also associated with significantly worse adherence (24% of the patients) than a longer-standing disease (15% of the patients; P = 0.001, OR: 2.1, CI: 1.30-3.39) in the same study.…”

Section: Age and Disease Durationmentioning

confidence: 99%

“…Most studies are consistent in finding that topical therapy with enemas, suppositories or foams is more likely to be associated with non-adherence than oral therapy. In an Italian study [22] , topical therapy with enemas was associated with significantly more non-adherence (68% of users) than oral therapy (40% of users; P = 0.001, OR: 0.25, CI: 0.11-0.60). Similarly, analyzing a national prescription-based database also showed that overall adherence to mesalazine was unexpectedly low and the rectal formulation was among the factors influencing non-adherence [25] .…”

Section: Drug Type and Dosing Regimesmentioning

confidence: 99%

“…The partnership between patient and the treating physician is of utmost importance in determining medical adherence, where effective patient-physician dialog is central to promoting patient adherence [22] . Studies have also shown that the interaction between the patient and the physician has a huge impact on health outcomes and costs.…”

Section: Patient-doctor Relationshipmentioning

confidence: 99%

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Prevalence, predictors, and clinical consequences of medical adherence in IBD: How to improve it?

Lakatos¹

2009

WJG

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Inflammatory bowel diseases (IBD) are chronic diseases with a relapsing-remitting disease course necessitating lifelong treatment. However, non-adherence has been reported in over 40% of patients, especially those in remission taking maintenance therapies for IBD. The economical impact of non-adherence to medical therapy including absenteeism, hospitalization risk, and the health care costs in chronic conditions, is enormous. The causes of medication non-adherence are complex, where the patient-doctor relationship, treatment regimen, and other disease-related factors play key roles. Moreover, subjective assessment might underestimate adherence. Poor adherence may result in more frequent relapses, a disabling disease course, in ulcerative colitis, and an increased risk for colorectal cancer. Improving medication adherence in patients is an important challenge for physicians. Understanding the different patient types, the reasons given by patients for non-adherence, simpler and more convenient dosage regimens, dynamic communication within the health care team, a self-management package incorporating enhanced patient education and physician-patient interaction, and identifying the predictors of nonadherence will help devise suitable plans to optimize patient adherence. This editorial summarizes the available literature on frequency, predictors, clinical consequences, and strategies for improving medical adherence in patients with IBD.

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Section: Drug Type and Dosing Regimessupporting

confidence: 78%

Section: Age and Disease Durationmentioning

confidence: 43%

Section: Age and Disease Durationmentioning

confidence: 99%

Section: Drug Type and Dosing Regimesmentioning

confidence: 99%

Section: Patient-doctor Relationshipmentioning

confidence: 99%

See 3 more Smart Citations

Prevalence, predictors, and clinical consequences of medical adherence in IBD: How to improve it?

Lakatos¹

2009

WJG

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Advanced Nanomedicine: Redefining Therapeutic Paradigms for Inflammatory Bowel Disease

Zhang

Wang

Sun

et al. 2023

Adv Healthcare Materials

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Inflammatory bowel disease (IBD), a chronic and recurrent gastrointestinal inflammatory disorder with a variety of painful clinical manifestations and an increased risk of cancerization or death, has become an emerging challenge to global healthcare due to its rapidly increasing incidence. At present, there is no efficient cure against IBD because of the elusive etiology and pathogenesis of IBD. Therefore, the development of alternative therapeutic strategies with positive clinical efficacy and reduced side effects is urgently needed. In recent years, the great prosperity of nanomedicine promoted by a variety of advanced nanomaterials is redefining more attractive and promising therapeutic strategies for IBD owing to their advantages in the physiological stability, bioavailability, and targeting of inflammatory sites. In this review, firstly the basic characteristics of healthy and inflammatory intestinal microenvironments are presented. Then, different administration routes and targeting strategies of nanotherapeutics for IBD treatment are reviewed. Subsequently, a specific focus is placed on the introduction of nanotherapeutic treatments based on different IBD pathogenesis. Finally, some future challenges and perspectives of the currently developed nanomedicines for IBD treatment are provided. It is believed that the above topics will attract researchers from various fields including medicine, biological sciences, materials, chemistry and pharmaceutics.

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Attitudes to medication and effects of IBD nursing service among patients with inflammatory bowel disease in Taiwan

Yang,

Hsu,

Chen

et al. 2024

Adv in Digestive Medicine

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Medication adherence is crucial in inflammatory bowel disease (IBD). This study aimed to evaluate attitudes to medication and the effects of IBD nursing services in a Taiwanese cohort. Sixty four adult patients with IBD were invited to complete a questionnaire at Changhua Christian Hospital between October 2020 and June 2021. All the patients (32 with Crohn's disease and 32 with ulcerative colitis) completed the questionnaire. Regarding medication adherence, most patients were highly or moderately adherent and reported never or sometimes forgetting to take medication (100% for steroids and 90.7% to 91.2% for other medications). Regarding worries about adverse reactions, 38.8%, 40.3%, 12.8%, and 6.1% of patients never or rarely, sometimes, often, and always felt worried about adverse reactions, respectively. Regarding the usefulness of IBD nursing service for disease education, medication education, and scheduling of an outpatient clinic, approximately 10.9% to 12.5% of patients felt useful, and 78.1% felt very useful. Our study showed a higher adherence rate and lower worries about adverse reactions, which may be the effects of IBD nursing service at our institution.

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Risk factors for non‐adherence to medication in inflammatory bowel disease patients

Abstract: SUMMARY BackgroundInflammatory bowel diseases are chronic conditions requiring medication throughout life to treat the disease and control the risk of relapse and colorectal cancer. Adherence to prescribed drugs is therefore crucial to their management.

Cited by 121 publications

References 38 publications

Prevalence, predictors, and clinical consequences of medical adherence in IBD: How to improve it?

Prevalence, predictors, and clinical consequences of medical adherence in IBD: How to improve it?

Advanced Nanomedicine: Redefining Therapeutic Paradigms for Inflammatory Bowel Disease

Attitudes to medication and effects of IBD nursing service among patients with inflammatory bowel disease in Taiwan

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