Risk factors for multidrug-resistant tuberculosis in urban Pakistan: A multicenter case–control study

Ahmad, Ahsan; Akhtar, Saeed; Hasan, Rumina; Khan, Javaid Ahmed; Hussain, Syed Fayyaz; Rizvi, Nadeem

doi:10.1016/j.ijmyco.2012.07.007

Cited by 45 publications

(55 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The irregular medication caused disease relapse and drug-resistant Mtb became the dominant bacteria. The cavity was also another risk factor in our report, which In accordance with the study of Ahmad AM et al [16]. There were lots of drug-resistant Mtb in the cavity, so the Mtb might spread easily.…”

Section: Discussionsupporting

confidence: 91%

The Gene Mutation and Drug Resistant of Mycobacterium tuberculosis in Patients of Chongqing

Tang¹,

Song²,

Su³

2018

Arch Microbiol Immunology

View full text Add to dashboard Cite

Objective: To detect the infection and drug resistance of Mycobacterium tuberculosis (MTB) in Chongqing and provide a scientific basis for the prevention and treatment of tuberculosis. Methods: DNA was collected from all new suspected patients in Chongqing from January 2014 to September 2017, Genechip technology was used to identify Mtb strain. Genechip technology detects mutations in the ropB gene (associated with resistance to rifampicin) at locus 511, locus 513, locus 516 locus 526, locus 531 or locus 533. Genechip technology was also used to detect mutations in the KatG gene and inhA gene． Results: Genechip revealed that the Mtb infected male accounted for 73.98% and female accounted for 26.12%.The total drug resistance rate of rifampicin and isoniazid were 11.2% (122/110771). Genechip revealed that ropB gene of 72 strains were mutation. The highest mutation site was 531 (TCG) locus (37.5%, 27/72). The people with katG and inhA gene mutation were 50 patients. The most common mutation site was 315 (AGC) locus. The cavity, history of treatment, and irregular medication were the risk factor of drug-resistant Mtb. Conclusion: Our report demonstrated the infected ratio and the drug resistant types of Mtb in Chongqing district. We should strengthen health management and provide psychosocial support, in order to reduce the risk of drugresistant Mtb

show abstract

Section: Discussionsupporting

confidence: 91%

The Gene Mutation and Drug Resistant of Mycobacterium tuberculosis in Patients of Chongqing

Tang¹,

Song²,

Su³

2018

Arch Microbiol Immunology

View full text Add to dashboard Cite

show abstract

“…This study conducted an analysis of sputum samples from patients with presumed MDR-TB and identified a high percentage of MDR-TB strains. One explanation may be close contact with known TB and MDR-TB patients, an association that was reported in several studies [9][10][11][12]. However, other risk factors associated with MDR-TB may be age, previous history of TB, HIV coinfection and alcohol consumption but not TB contact as reported elsewhere [13].…”

Section: Discussionmentioning

confidence: 87%

Characterization of katG, inhA, rpoB and pncA in Mycobacterium tuberculosis isolates from MDR-TB risk patients in Thailand

Suthum

Samosornsuk

2020

J Infect Dev Ctries

View full text Add to dashboard Cite

Introduction: Multidrug-resistant tuberculosis (MDR-TB) is commonly found in Thailand especially in the public health region 5, the Western region of Thailand. This study’s aim was to characterize katG, inhA, rpoB and pncA genes in Mycobacterium tuberculosis. Methodology: One hundred strains of Mycobacterium tuberculosis (MTB) were isolated from sputum samples of MDR-TB risk patients in the laboratory of the Office of Disease Prevention and Control 5th Ratchaburi province, Thailand from January to December 2015. Drug susceptibility testing (DST) was performed using a BACTEC MGIT 960 system. Furthermore, the genes katG, inhA, rpoB and pncA were characterized by DNA sequencing. Results: Of a total of 100 MTB samples which underwent drug susceptibility testing, 42% showed isoniazid (INH) and rifampicin (RIF) resistance, and a further 25% showed INH mono-resistance (25%). The most common gene mutations found using DNA sequencing were katG_Ser315Thr (70%), rpoB_Ser531leu (81%) and pncA_Ile31Thr (84%). The common mutation of pncA_Ile31Thr substitution was detected in 26 of 91 (29%) pyrazinamide (PZA) susceptible isolates. Conclusion: Using DNA sequencing to screen for gene mutations conferring drug resistance may be feasible and use less time than using DST to detect resistance patterns.

show abstract

“…Penelitian Ahmad (2012), menyebutkan bahwa laki-laki dianggap relatif tidak peduli daripada wanita terkait asupan OAT secara teratur, dan fakta ini mungkin menyebabkan lebih banyak laki-laki yang menderita TB MDR. Hal ini sejalan dengan penelitian Maharatta (2010) yang menyatakan bahwa TB MDR terbanyak ditemukan pada jenis kelamin lakilaki dibandingkan perempuan, baik pada kelompok kasus maupun kontrol di dalam penelitian tersebut.…”

Section: Dataunclassified

“…Keluarga yang mempunyai pendapatan di bawah Upah Minimum Regional (UMR) akan mengkonsumsi makanan dengan kadar gizi yang tidak mencukupi kebutuhan bagi setiap anggota keluarga sehingga mempunyai status gizi yang kurang dan akan menjadikan risiko terkena penyakit infeksi TB MDR (Aderita, 2016). Pada penelitian Ahmad (2012) menyebutkan bahwa pendapatan rendah berisiko 3 kali untuk kejadian TB MDR (OR= 3,95%CI= 1,3-7,1). Berdasarkan hasil penelitian menunjukkan bahwa variabel pendapatan memiliki interval kepercayaan 1,133-4.317 (tidak mencakup angka 1) dan p value sebesar 0,030 < α (0,05), yang artinya ada hubungan antara pendapatan dengan kejadian TB MDR.…”

Section: Dataunclassified

Kejadian Tuberkulosis Multi Drug Resistant di RSUP dr. Kariadi

Triandari¹,

Rahayu²

2018

HIGEIA

View full text Add to dashboard Cite

Indonesia ranks 8th out of 27 countries with high priority burden of MDR TB. MDR Tuberculosis at Dr. Kariadi has increased over the last 3 years. In 2014 there were 688 cases, 2015 there were 1,183 cases, 2014 reached 1442 cases, until May 2017 reached 2,061 cases. The purpose of this study was to analyze factors related to MDR TB incidence at RSUP. Dr. Kariadi Kota Semarang. This research was analytic observational case control design. The samples were 72 cases and 72 controls by purposive sampling technique. Research Instruments used questionnaires and medical records. Data were analyzed univariate, bivariate (chi square test) and multivariate (logistic regression test) with SPSS. The results show that the active role of PMO (OR = 2.37, 95% CI = 1.14-4.89), result of TB treatment (OR = 5.64; 95% CI = 2.23 -14,23), and medication adherence (OR = 2.49; 95% CI = 1.17-5.28 ) was associated with MDR TB incidence at the RSUP. Dr. Kariadi Kota Semarang.The most dominant factor with the incidence of MDR TB was result of TB treatment.

show abstract

Risk factors for multidrug-resistant tuberculosis in urban Pakistan: A multicenter case–control study

Cited by 45 publications

References 15 publications

The Gene Mutation and Drug Resistant of Mycobacterium tuberculosis in Patients of Chongqing

The Gene Mutation and Drug Resistant of Mycobacterium tuberculosis in Patients of Chongqing

Characterization of katG, inhA, rpoB and pncA in Mycobacterium tuberculosis isolates from MDR-TB risk patients in Thailand

Kejadian Tuberkulosis Multi Drug Resistant di RSUP dr. Kariadi

Contact Info

Product

Resources

About