Risk Factors for Mortality in 272 Patients With Lung Transplant: A Multicenter Analysis of 7 Intensive Care Units

Rello, Jordi; Bello, Irene; Vicente, R.; Anchuelo, Ana Hermira; Ballesteros, M.Á.; Iranzo, Reyes; Rellán, Luzdivina; Riera, Jordi; Robles, Juan Carlos

doi:10.1016/j.arbres.2016.12.019

Cited by 11 publications

(7 citation statements)

References 17 publications

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“…In our series, no relation was found between the PaO 2 /FiO 2 ratio measured at the end of surgery and the risk of grade 3 PGD or mortality up to 1000 days after transplantation. Rello et al recently showed that a low PaO 2 /FiO 2 ratio at ICU admission was significantly associated with 90‐day mortality. Prekker et al assessed the prognostic value of PaO 2 /FiO 2 ratio within 12 hours of patient's arrival at the ICU.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of the PaO₂/FiO₂ ratio determined at the end‐surgery stage of a double‐lung transplantation

Fessler

Thès

Pirracchio

et al. 2019

Clinical Transplantation

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Introduction We evaluated the prognostic role of the arterial oxygen partial pressure/fractional inspired oxygen ratio (PaO2/FiO2 ratio) measured at the end of double‐lung transplantation (DLT). Methods This was a monocentric cohort study of all consecutive DLT patients between January 1, 2012, and January 1, 2016, except patients with preoperative extracorporeal membrane oxygenation (ECMO), intraoperative cardiopulmonary bypass, postoperative ECMO, large patent foramen ovale, redo transplantation during the study period, and multiorgan transplantation. Results A total of 164 patients were included in the study; 45 had a PaO2/FiO2 ratio <200, 39 a ratio in the range 200‐300, and 80 a ratio >300. The risk of being in the lower ratio group is positively related to body mass index, preoperative pulmonary hypertension, and fibrosis. It is negatively related to emergency surgery, age, and intraoperative institution of ECMO. There was a trend for more grade 3 pulmonary graft dysfunction at day 3 in the worst PaO2/FiO2 ratio group. Mortality at 1000 days was similar for all patients and even after exclusion of patients who had required intraoperative ECMO. Conclusion PaO2/FiO2 ratio measured at the end of DLT does not forecast 1000‐day mortality.

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Section: Discussionmentioning

confidence: 99%

Prognostic value of the PaO₂/FiO₂ ratio determined at the end‐surgery stage of a double‐lung transplantation

Fessler

Thès

Pirracchio

et al. 2019

Clinical Transplantation

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“…Fazleen et al did not find a relationship between CRP and prolonged intubation, ICU or hospital stay, and five-year survival rate after lung or heart and lung transplantation in the cohort of 72 CF patients [ 37 ]. In addition, multicenter analysis by Rello et al failed to show a relationship between CRP and mortality after LuTx [ 38 ]. Our results contrasted with those findings.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Donor to Recipient Pathogen Transmission in Relation to Cold Ischemic Time and Other Selected Aspects of Lung Transplantation—Single Center Experience

et al. 2023

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Background: Infections are one of the leading causes of death in the early postoperative period after lung transplantation (LuTx). Methods: We analyzed 59 transplantations and culture results of the donor bronchial aspirates (DBA), graft endobronchial swabs (GES), and recipient cultures (RC) before and after the procedure (RBA). We correlated the results with a cold ischemic time (CIT), recipient intubation time, and length of stay in the hospital and intensive care unit (ICU), among others. Results: CIT of the first and second lungs were 403 and 541 min, respectively. Forty-two and eighty-three percent of cultures were positive in DBA and GES, respectively. Furthermore, positive results were obtained in 79.7% of RC and in 33.9% of RBA. Longer donor hospitalization was correlated with Gram-negative bacteria isolation in DBA. Longer CIT was associated with Gram-positive bacteria other than Staphylococcus aureus in GES and it resulted in longer recipient stay in the ICU. Furthermore, longer CIT resulted in the development of the new pathogens in RBA. Conclusion: Results of GES brought more clinically relevant information than DBA. Donor hospitalization was associated with the occurrence of Gram-negative bacteria. Positive cultures of DBA, GES, and RBA were not associated with recipient death.

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“…18 acute rejection and infectious complications are known predisposing factors to cLad but the real weight of each event on prognosis is far to be assessable. [19][20][21][22][23][24] Well-known and widely employed clinical scoring systems (apacHe, cUrB65, sirs or pneumonia severity index), validated in other clinical settings are not specific for transplanted patients and do not predict long-term survival. 25 Bacterial and mycotic agents isolated on BaL had higher seLect scores than viral infection and acute rejections.…”

Section: Discussionmentioning

confidence: 99%

Analysis of survival in lung transplantation: simple diagnostic tests in a new "SELeCT" Score used as prognostic tool. Results from a single center cohort study

Patrucco¹,

Albera²,

Clivati³

et al. 2022

Minerva Respir Med

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BacKGroUNd: there are few validated scores evaluating outcomes of lung transplanted patients based on donor or recipient characteristic before or at the time of transplantation. MetHods: in our study we evaluated a new, and easy to use, 5-item score on survival of patients who underwent lung transplantation. It was called SELeCT Score and was based on clinical, laboratoristic and radiological findings recorded at each observation. resULts: We found higher scores in case of unscheduled observations and an inverse correlation with overall survival rate, even excluding patients who died within 60 days. We identified a threshold of 2 points as significant to predict patients' survival. Fungal and bacterial infections show scores higher than acute rejections and cMV and other viral infections. coNcLUsioNs: seLect score could represent a useful prognostic tool in guiding clinical choices, demonstrating that more compromised patients (routinely evaluated with clinic, laboratory test and radiological images) had a worse outcome, and that it could be important at least as much as the identification of the etiology.

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Risk Factors for Mortality in 272 Patients With Lung Transplant: A Multicenter Analysis of 7 Intensive Care Units

Cited by 11 publications

References 17 publications

Prognostic value of the PaO₂/FiO₂ ratio determined at the end‐surgery stage of a double‐lung transplantation

Prognostic value of the PaO₂/FiO₂ ratio determined at the end‐surgery stage of a double‐lung transplantation

Analysis of Donor to Recipient Pathogen Transmission in Relation to Cold Ischemic Time and Other Selected Aspects of Lung Transplantation—Single Center Experience

Analysis of survival in lung transplantation: simple diagnostic tests in a new "SELeCT" Score used as prognostic tool. Results from a single center cohort study

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Risk Factors for Mortality in 272 Patients With Lung Transplant: A Multicenter Analysis of 7 Intensive Care Units

Cited by 11 publications

References 17 publications

Prognostic value of the PaO2/FiO2 ratio determined at the end‐surgery stage of a double‐lung transplantation

Prognostic value of the PaO2/FiO2 ratio determined at the end‐surgery stage of a double‐lung transplantation

Analysis of Donor to Recipient Pathogen Transmission in Relation to Cold Ischemic Time and Other Selected Aspects of Lung Transplantation—Single Center Experience

Analysis of survival in lung transplantation: simple diagnostic tests in a new "SELeCT" Score used as prognostic tool. Results from a single center cohort study

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Prognostic value of the PaO₂/FiO₂ ratio determined at the end‐surgery stage of a double‐lung transplantation

Prognostic value of the PaO₂/FiO₂ ratio determined at the end‐surgery stage of a double‐lung transplantation