“…aureus infections such as BSIs, endocarditis, and surgical site infections can cause significant morbidity [17] and mortality in patients with cancer [18 -21]. In addition, factors such as sepsis and comorbid conditions have been associated with increased MRSA-associated mortality in patients with cancer [22]. On the other hand, scarce data exist on vancomycin treatment outcomes or risk factors for treatment failure and MRSA-associated mortality in patients with cancer and MRSA BSIs.…”
Results. The treatment failure rate was 52% (116 of 223 patients). These patients were more likely to have been hospitalized, been treated with steroids within the previous 3 months, developed acute respiratory distress syndrome, required mechanical ventilation, required intensive care unit care, and community-onset infections (all p < .05). Risk factors for MRSA-associated mortality (27 of 223 pa-
“…aureus infections such as BSIs, endocarditis, and surgical site infections can cause significant morbidity [17] and mortality in patients with cancer [18 -21]. In addition, factors such as sepsis and comorbid conditions have been associated with increased MRSA-associated mortality in patients with cancer [22]. On the other hand, scarce data exist on vancomycin treatment outcomes or risk factors for treatment failure and MRSA-associated mortality in patients with cancer and MRSA BSIs.…”
Results. The treatment failure rate was 52% (116 of 223 patients). These patients were more likely to have been hospitalized, been treated with steroids within the previous 3 months, developed acute respiratory distress syndrome, required mechanical ventilation, required intensive care unit care, and community-onset infections (all p < .05). Risk factors for MRSA-associated mortality (27 of 223 pa-
“…Interestingly cancer patients have multiple predisposing factors that increase the risk of infection such as chemotherapy, radiation therapy, surgery, stem cell transplantation, bone marrow transplantation or steroids in addition to suppressed immune system. Cuervo SI [35] et al in their review found that the risk factors in cancer patients do not differ considerably from noncancerous patients. Mucosal barriers due to intervention of anti malignant chemotherapy, radiotherapy and progressive neoplastic disease predispose to risk factor.…”
Staphylococcus aureus (S.aureus) a gram positive commonly isolated pathogen is known for multi drug resistance and nosocomial infection. A 3 year review study of S.aureus isolated from clinical samples of cancer patients (lymphohaematological malignancies and solid tumors) was done in the department
“…En cuanto a las bacteriemias por grampositivos, S. aureus se aisló en el 17.9% de los episodios. Este hallazgo confirma la tendencia observada en la literatura médica donde S. aureus fue la causa del 11-33% de las bacteriemias nosocomiales según un estudio realizado en Bogotá [24]. Los Staphylococcus coagulasa negativa le siguieron en frecuencia y en menor proporción; también se aislaron S. pneumoniae, Streptococcus beta hemolítico del grupo C (SBGC) y enterococos.…”
Objetivo: caracterizar los episodios de bacteriemias, los microorganismos causantes y sus patrones de sensibilidad, en pacientes atendidos en el Instituto del Cáncer SOLCA-Cuenca, Ecuador. Metodología: se utilizó un diseño descriptivo. El estudio se enfocó en todos los episodios de bacteriemias ocurridos en el periodo 2011-2016 verificados mediante hemocultivos. Las variables estudiadas fueron edad y sexo de los pacientes en los que se produjo la bacteriemia; tipo de tumor, microorganismo, tiempo de positivización y perfil de resistencia. Resultados: se identificaron 318 episodios. El 66.8% de los microorganismos aislados fueron bacterias gramnegativas y el 33.2% grampositivas; los más prevalentes fueron Escherichia coli 37.3%, Staphylococcus aureus 17.9%, Klebsiella.spp 9.3%, Estafilococos coagulasa negativa 7.2% y Pseudomonas aeruginosa 5.1%. En los cocos grampositivos, la meticilino resistencia fue de 40% en Staphylococcus aureus.y 67% en Staphylococcus coagulasa negativa; Escherichia coli y Klebsiella pneumoniae fueron resistentes a cefalosporinas de tercera generación en un 29% y 47%, respectivamente, compatibles con el fenotipo de beta-lactamasa de espectro extendido; la resistencia a quinolonas fue 35% y 50% respectivamente. Conclusiones: las bacterias gramnegativas fueron los microorganismos más prevalentes en este estudio, principalmente enterobacterias, con una importante resistencia a los antibióticos ensayados.
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