Risk Factors for Mortality among COVID-19 Patients in Besut Region, Terengganu, Malaysia

Awang, Hafizuddin; Yaacob, Effah Leiylena; Daud, Arfizah Ahmad; Ahmad, Normahizan; Ishak, Muhammad Solehuddin; Alias, Nur Almas; Ghazali, Nor Hafizah; Ismail, Nur Farihin; Khalim, Mohd Adli Abd; Yusof, Saidah Adilah Mohamed; Samsury, Siti Fatimah; Rahman, Mohd Anuar Abd; Embong, Kasemani

doi:10.24018/ejmed.2022.4.3.1307

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…30 Declining function of the third line defense in the body such as T and B lymphocytes and increased inflammatory mediators such as type 2 cytokines concurrently causing chronic inflammation, severe conditions and subsequent death. 31,32 In this study, COVID-19 patients with comorbidity particularly among elderly group were commonly presented with hypertension and/or diabetes. Nevertheless, a previous study has highlighted that hypertension and diabetes were not significantly associated with mortality, but chronic inflammation, compromised innate immune system and increase coagulation activity among diabetic patients were most likely the cause of severity and mortality.…”

Section: Clinical Outcomementioning

confidence: 76%

Patient characteristics and risk factors contributing to mortality among hospitalised patients with COVID-19 in Malaysia

Othman,

Taufek,

Rahman

et al. 2023

PHARMPRACT

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Background:The COVID-19 pandemic caused a significant increase in deaths globally. However, there is a scarcity of data addressing risk factors associated with mortality among hospitalised COVID-19 patients in Malaysia. This study aimed to identify the predictors of death among hospitalised COVID-19 patients in Malaysia. Methods: A retrospective cross-sectional study was conducted at two public hospitals in East Coast Malaysia from February 2020 to August 2021. The study included all hospitalised COVID-19 patients by extracting data from the electronic medical records focusing on patient demographics and clinical outcomes. Univariable and multivariable logistic regression analyses were conducted to evaluate association between risk factors and mortality among COVID-19 patients. Results: A total of 1060 patients were included (59% male) with median age of 41.5 years (IQR 27 -58.5). Multivariable logistic regression showed that factors contributing to mortality of COVID-19 patients were elderly (OR, 1.04; 95% CI, 1.02, 1.06; p = 0.001), chronic kidney disease (OR, 3.75; 95% CI, 1.25, 11.27; p = 0.019), an increased point of CCI score (OR, 1.59; 95% CI, 1.25, 2.05; p = ≤0.05), progression to severe stage (OR, 40.68; 95% CI, 17.55, 94.31; p = ≤ 0.05) and admitted to intensive care unit (ICU) (OR, 2.68; 95% CI, 1.16, 6.17, p = 0.021). Conclusion: Patients who were elderly, with chronic kidney disease, multiple comorbidities, progressed to severe stage and admitted to ICU were at significantly increased risk of mortality. These findings highlight the importance of implementing extra monitoring and aggressive preventive measures for high-risk patients, in order to reduce their mortality risk and improve patient outcomes.

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Section: Clinical Outcomementioning

confidence: 76%

Patient characteristics and risk factors contributing to mortality among hospitalised patients with COVID-19 in Malaysia

Othman,

Taufek,

Rahman

et al. 2023

PHARMPRACT

View full text Add to dashboard Cite

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Epidemiology of Poor Glycaemic Control among Patients with Type 2 Diabetes Mellitus in Terengganu State of Malaysia

Awang¹,

Muda

Rusli

et al. 2022

EJMED

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Background: Type 2 diabetes mellitus (T2DM) is among the most common non-communicable diseases worldwide and Malaysia. Poor glycaemic control among T2DM patients lead to serious life-long complications. Therefore, it is imperative to study the prevalence of poor glycaemic control and its risk factors to facilitate public health physicians and clinicians in developing the best strategies to optimize glycaemic control among T2DM patients. Materials and Methods: A comparative cross-sectional study between groups of good glycaemic control and poor glycaemic control was conducted among type 2 diabetes mellitus (T2DM) patients who fulfilled study criteria in Terengganu state of Malaysia. Eligible samples in the National Diabetes Registry registered from 1st January 2021 until 31st December 2021 were included into the study. Descriptive statistics, simple and multiple logistic regressions were employed for data analysis. Result: A total of 17,165 samples were recruited in the descriptive part of the study. The prevalence of patients with poor glycaemic control in Terengganu state was 65.3% (95% CI: 0.62, 0.67). In the inferential part of the study, a total 3,700 samples were randomly selected. Multivariable analysis using multiple logistic regression revealed age, duration of diabetes, body mass index, cigarette smoking, presence of retinopathy and presence of hypertension were the significant factors associated with poor glycaemic control among T2DM patients in Terengganu state with an adjusted odds ratio (AOR) of 0.95 (95%CI:0.94, 0.96); p<0.001), AOR 1.15 (95%CI:1.13, 1.17; p<0.001), AOR 1.03 (95%CI:1.01, 1.04; p<0.001), AOR 1.45 (95%CI:1.01, 2.10; p=0.047), AOR 1.32 (95%CI:1.01, 1.73; p=0.043) and AOR 1.39 (95%CI:1.16, 1.67; p<0.001) respectively. Conclusion: Strategies focusing on the identified risk factors may improve diabetes mellitus management and avert life-long diabetic complications.

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Risk Factors for Mortality among COVID-19 Patients in Besut Region, Terengganu, Malaysia

Cited by 2 publications

References 23 publications

Patient characteristics and risk factors contributing to mortality among hospitalised patients with COVID-19 in Malaysia

Patient characteristics and risk factors contributing to mortality among hospitalised patients with COVID-19 in Malaysia

Epidemiology of Poor Glycaemic Control among Patients with Type 2 Diabetes Mellitus in Terengganu State of Malaysia

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